Eczema
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our meta-analysis revealed a novel finding that the heterogeneous "GA" genotype of the TLR2 rs5743708 and "AG" genotype of the TLR4 rs4986790 may be associated with increased susceptibility to atopic dermatitis in Caucasians.
|
30273064 |
2019 |
Eczema
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Keratinocytes from both healthy and AD skin expressed similar levels of TLR2.
|
29672867 |
2018 |
Eczema
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To evaluate whether single nucleotide polymorphisms in the TLR2 gene c.2258C>T (R753Q) (rs5743708) and TLR2 c.-148+1614T>A (A-16934T) (rs4696480) (NM_0032643) are associated with atopic dermatitis in Turkish children.
|
28443596 |
2017 |
Eczema
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association of Toll-Like Cell Receptors TLR2 (p.Arg753GLN) and TLR4 (p.Asp299GLY) Polymorphisms with Indicators of General and Local Immunity in Patients with Atopic Dermatitis.
|
28593178 |
2017 |
Eczema
|
0.100 |
Biomarker
|
disease |
BEFREE |
Significant correlations between TLR2(+) (but not TLR4(+)) PB monocytes and the objective Scoring Atopic Dermatitis index (r = 0.604, p < 0.001), serum levels of IL-17a and TLR2(+) PB monocytes (r = 0.416, p = 0.027), and IL-4 and TLR2(+) PB monocytes (r = -0.307, p = 0.014) were observed during AD exacerbation.
|
26534745 |
2016 |
Eczema
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Peripheral blood monocytes from patients with severe extrinsic AD or healthy control patients were treated with the TLR2 agonist Pam3CSK4.
|
25912722 |
2015 |
Eczema
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, the effect of TLR2 ligands on the development of TH2-mediated AD inflammation remains unclear.
|
24698321 |
2014 |
Eczema
|
0.100 |
Biomarker
|
disease |
BEFREE |
Activation of epidermal toll-like receptor 2 enhances tight junction function: implications for atopic dermatitis and skin barrier repair.
|
23223142 |
2013 |
Eczema
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Distinct number of Tregs and various distribution of TLR2 and TLR4 expression on PBMC in AD patients suggest their contribution in the pathogenesis of AD.
|
22686584 |
2012 |
Eczema
|
0.100 |
Biomarker
|
disease |
BEFREE |
Altered function of IL-31 may have implications for cutaneous inflammation in eczema where skin colonization with Staphylococcus aureus and dysregulation of TLR-2 have been described.
|
21261663 |
2011 |
Eczema
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The aim of this study was to investigate intrinsic TLR-2 expression and cytokine secretion upon TLR-2 stimulation with peptidoglycan (PGN), lipoteichoic acid (LTA) and N-palmitoyl-S-[2,3-bis(palmitoyl)-(2RS)-propyl]-(R)cysteinyl-alanyl-glycine (Pam3Cys) in keratinocytes from patients with AD compared to healthy controls.
|
21447101 |
2011 |
Eczema
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Genotyping for TLR2–16934A>T polymorphism was performed in 130 consecutive adult ambulatory patients with AD.
|
21134221 |
2011 |
Eczema
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
CONCLUSION Children with AD may have a distinct genotype and the TLR-2 R753Q SNP was prevalent in a subset of patients with AD characterized by a more severe clinical picture.
|
22032785 |
2011 |
Eczema
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Dysregulation of CD36 upon TLR-2 stimulation in monocytes from patients with atopic dermatitis and the TLR2 R753Q polymorphism.
|
19849713 |
2010 |
Eczema
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In our cohort, no evidence of correlation between TLR-2 or TLR-4 polymorphism and eczema and food allergy incidence and/or severity was found.
|
20646366 |
2010 |
Eczema
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We could clearly show that macrophages from patients with AD expressed significantly less TLR-2, whereas the expression pattern of TLR-1 and TLR-6 were not altered.
|
19392987 |
2009 |
Eczema
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In a subgroup of patients suffering from severe AD (SCORAD >50), a significantly increased representation of the A-allele in position -16934 of the tlr2 gene was present (P = 0.004).
|
19627277 |
2009 |
Eczema
|
0.100 |
Biomarker
|
disease |
BEFREE |
TLR-2 may be essential in the pathogenesis and maintenance of AD and may be involved in the enhanced susceptibility to skin infections with S. aureus and in a higher inflammatory response in patients with AD carrying the TLR-2 polymorphism.
|
18445187 |
2008 |
Eczema
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In contrast, LTA decreased TLR-2 expression among nonatopic individuals and patients with AD with the TLR-2 wild-type gene.
|
18234309 |
2008 |