TLR2, toll like receptor 2, 7097

N. diseases: 749; N. variants: 15
Disease: Kidney Failure, Acute ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0022660
Disease: Kidney Failure, Acute
Kidney Failure, Acute 		0.360 Biomarker disease BEFREE TLR2-deficient mice exacerbated renal injury in cisplatin-induced AKI, with higher serum creatinine and blood urea nitrogen, more severe morphological injury compared with that of wild-type mice. 30387162 2019
CUI: C0022660
Disease: Kidney Failure, Acute
Kidney Failure, Acute 		0.360 Biomarker disease BEFREE For the present study, it was hypothesized that TLR2 inhibition could reduce inflammation and consequently prevent septic AKI. 31798708 2019
CUI: C0022660
Disease: Kidney Failure, Acute
Kidney Failure, Acute 		0.360 Biomarker disease BEFREE Adoptive transfer of TLR-2-primed WTDCs significantly expanded Tregs in the kidneys of CDDP-treated WT and Gal-3<sup>-/-</sup> recipients resulting in the suppression of IFN-γ and IL-17-driven inflammation and alleviation of AKI. 31534532 2019
CUI: C0022660
Disease: Kidney Failure, Acute
Kidney Failure, Acute 		0.360 Biomarker disease CTD_human Relevance of megalin receptor injury with nuclear factor-kappa B upregulation in acute kidney injury induced in rats. 29286200 2018
CUI: C0022660
Disease: Kidney Failure, Acute
Kidney Failure, Acute 		0.360 Biomarker disease BEFREE Hence, the present study aimed to evaluate the specific participation of TLR2 and TLR4 molecules on the development of cisplatin-induced AKI. 29500224 2018
CUI: C0022660
Disease: Kidney Failure, Acute
Kidney Failure, Acute 		0.360 Biomarker disease BEFREE We propose that the TLR1/TLR2 heterodimer may be a new therapeutic target for the prevention of acute kidney injury in diabetic patients. 28822965 2017
CUI: C0022660
Disease: Kidney Failure, Acute
Kidney Failure, Acute 		0.360 Biomarker disease BEFREE Biglycan-triggered TLR-2- and TLR-4-signaling exacerbates the pathophysiology of ischemic acute kidney injury. 24480070 2014