|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Subgroups analyses indicated decreased risk of HBV-related HCC in relation to TLR3 rs3775290 CC/CT genotype (P = 0.022), with increased risk ascribed to the minor (T) allele (P = 0.04).
|
30421643 |
2019 |
|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In our study, we analysed the impact of the TLR3 polymorphisms rs3775291 and rs5743305 on the natural course of HBV infection.
|
30143709 |
2018 |
|
Hepatitis B
|
0.100 |
Biomarker
|
disease |
BEFREE |
Herein, we have evaluated the immunostimulatory effects of SLA archaeosomes when used as adjuvant with ovalbumin (OVA) and hepatitis B surface antigen (HBsAg) and compared this to various other adjuvants including TLR3/4/9 agonists, oil-in-water and water-in-oil emulsions and aluminum hydroxide.
|
30513093 |
2018 |
|
Hepatitis B
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
However, liver specimens from patients with HBV infection did produce IFN and induce expression of ISGs following activation of TLR3 with poly(I:C) or Sendai virus infections, so the innate immune response is not suppressed in these tissues.
|
29408639 |
2018 |
|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study was to investigate the relationships of genetic variants in TLR2 and TLR3 with hepatitis B virus (HBV) natural clearance and HBV-related hepatocellular carcinoma (HCC) risk in a Chinese male population.
|
28009434 |
2017 |
|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The present study investigated the prevalence of two single-nucleotide polymorphisms (SNPs) in the Toll-like receptor 3 (TLR3) gene in patients infected with hepatitis B virus (HBV) and hepatitis C virus (HCV).
|
25992926 |
2016 |
|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
No statistically significant difference in TLR 3 1377C/T polymorphism was detected between healthy controls and the hepatitis B patients (p = 0.342).
|
27314608 |
2016 |
|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
There are inconsistent data on the association of risk of hepatitis virus infection and hepatitis virus-related diseases with the toll-like receptor 3 (TLR3) gene.Several common polymorphism sites were targeted to assess the risk of HBV infection, HCV infection, and HBV-related diseases.Meta-analysis combining data for 3547 cases and 2797 controls from 8 studies was performed in this study.
|
27227908 |
2016 |
|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Genetic polymorphisms in Toll-like receptor 3 gene are associated with the risk of hepatitis B virus-related liver diseases in a Chinese population.
|
26024592 |
2015 |
|
Hepatitis B
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings implicate the potential of intrahepatic TLR3 activation for the treatment of chronic HBV infection.
|
24920792 |
2014 |
|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
When analyzing the TLR3 +1234C/T polymorphism with different clinical parameters in HCC patients, the cases who were hepatitis B virus (HBV) carriers had higher number of +1234CT genotype and +1234T allele than those without HBV infection (p=0.032 and p=0.043).
|
23404408 |
2013 |
|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These results indicate that TLR3 C1234T polymorphism could be a risk factor for the development of chronic HBV infection, especially the CHB-related ACLF.
|
23076446 |
2013 |
|
Hepatitis B
|
0.100 |
Biomarker
|
disease |
BEFREE |
Based on the results reported here, it seems that CHB patients are unable to express appropriate levels of the TRIF gene, which may attenuate TLR3 and 4 signaling subsequent to HBV infection.
|
23433963 |
2013 |
|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Due to lack of knowledge on the role of TLR3 polymorphisms in HBV infection, this study investigated the distribution of nine SNPs in the TLR3 gene and its association with Saudi Arabian patients infected with HBV.
|
22825813 |
2012 |