|
Rhinovirus infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Genetic defects in several pattern recognition receptors include MDA5 deficiency, which impairs viral RNA sensing and confers human rhinovirus susceptibility; RNA polymerase III haploinsufficiency, which impairs sensing of A:T-rich virus DNA and confers VZV susceptibility; and TLR3 deficiency, which causes HSV-1 encephalitis (HSE) or influenza virus pneumonitis.
|
31693592 |
2019 |
|
Rhinovirus infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we studied the impact of a small-molecule inhibitor (MEKi) on the IFN response following challenge with two major respiratory viruses rhinovirus (RV2) and respiratory syncytial virus (RSVA2) and a TLR3 agonist, poly(I:C).
|
31319869 |
2019 |
|
Rhinovirus infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Airway Epithelial Cells Generate Pro-inflammatory Tenascin-C and Small Extracellular Vesicles in Response to TLR3 Stimuli and Rhinovirus Infection.
|
31497021 |
2019 |
|
Rhinovirus infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
We found that TLR3-ligand polyinosinic-polycytidylic acid and human rhinovirus infection induced a potent antiviral protection against Sendai and vesicular stomatitis virus in a TLR3 and type I IFN receptor-dependent manner.
|
26101320 |
2015 |
|
Rhinovirus infection
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
TLR3 and MDA5 signalling, although not expression, is impaired in asthmatic epithelial cells in response to rhinovirus infection.
|
24131248 |
2014 |
|
Rhinovirus infection
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, uninfected cells from severe therapy resistant asthmatic children showed lower levels of Toll-like receptor-3 mRNA and reduced retinoic acid inducible gene and melanoma differentiation-associated gene 5 mRNA after RV stimulation.
|
23212197 |
2013 |
|
Rhinovirus infection
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression of Toll-like receptor (TLR) 3, TLR7, TLR8, retinoic acid-inducible gene I (RIG-I), melanoma differentiation-associated gene 5 (MDA-5), TIR domain-containing adapter-inducing IFN-β (TRIF), myeloid differentiation primary response gene 88 (MyD88), caspase recruitment domain adaptor inducing IFN-β (CARDIF), IL-1 receptor-associated kinase 4 (IRAK4), IκB kinase β (IKKB), IκB kinase ι (IKKI), interferon regulatory factors 3 and 7, and rhinovirus induction of expression of the virus-inducible molecules TLR3, TLR7, RIG-I, and MDA-5 were not impaired in these interferon-deficient BAL cells in asthmatic patients.
|
22657407 |
2012 |
|
Rhinovirus infection
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We then treated the ASM cells with the Toll-like receptor (TLR) agonists polyinosinic:polycytidylic acid, imiquimod, and pure RV RNA and were able to show that the mechanism through which RV induced ECM deposition was via the activation of TLR3 and TLR7/8.
|
21460120 |
2011 |
|
Rhinovirus infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
Inhibition of TLR3 and TRIF using siRNA reduced rhinovirus induced RNA helicases.
|
21079690 |
2010 |
|
Rhinovirus infection
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
CSE increased RV-induced TLR3 expression and RV-induced IL-8 secretion at lower concentrations in A549 cells.
|
19769802 |
2010 |
|
Rhinovirus infection
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest that TLR3 and MDA5, but not RIG-I, are required for maximal sensing of RV dsRNA and that TLR3 and MDA5 signal through a common downstream signaling intermediate, IRF3.
|
19890046 |
2009 |
|
Rhinovirus infection
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Finally, siRNA against TLR3 attenuated RV-induced IL-8 expression.
|
16914605 |
2006 |