Hypertensive disease
|
0.400 |
Biomarker
|
group |
BEFREE |
<b>NEW & NOTEWORTHY</b> Angiotensin II (ANG II)-induced hypertension is dependent on the endosomal Toll-like receptor 3 (TLR3)-Toll-interleukin receptor domain-containing adaptor protein-inducing interferon-β (TRIF) pathway of the innate immune system but not on cell membrane localized TLR4.
|
30793936 |
2019 |
Hypertensive disease
|
0.400 |
Biomarker
|
group |
BEFREE |
TLR4 D299 G showed an inverse association with pulmonary hypertension.
|
25182168 |
2015 |
Hypertensive disease
|
0.400 |
Biomarker
|
group |
BEFREE |
Toll-like receptor 4 (TRL4) is a molecule involved in the immune response pathway and is quickly becoming a receptor of interest in the field of hypertension.
|
28738166 |
2017 |
Hypertensive disease
|
0.400 |
Biomarker
|
group |
BEFREE |
Toll-like receptor 4 (TLR4) has been implicated in the progression of cardiovascular disease, including hypertension.
|
29767672 |
2018 |
Hypertensive disease
|
0.400 |
Biomarker
|
group |
BEFREE |
Toll-like receptor 4 (TLR4) activation contributes to vascular dysfunction in pathological conditions such as hypertension and diabetes, but the role of chronic TLR4 activation on renal autoregulatory behavior is unknown.
|
31432707 |
2019 |
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
After adjustment for maternal age and chronic hypertension, attenuating allelic variants of TLR4 were more common in women with a history of early-onset preeclampsia than in controls (OR 2.9 [95% CI 1.2-6.7]).
|
18382655 |
2008 |
Hypertensive disease
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Animal study proved that HMGB1 contributed to the pathogenesis of experimental pulmonary hypertension (HT) via activation of TLR4.
|
25050807 |
2015 |
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Blockade of c-Src Within the Paraventricular Nucleus Attenuates Inflammatory Cytokines and Oxidative Stress in the Mechanism of the TLR4 Signal Pathway in Salt-Induced Hypertension.
|
31641986 |
2019 |
Hypertensive disease
|
0.400 |
Biomarker
|
group |
BEFREE |
Effects of small interfering RNA targeting TLR4 on expressions of adipocytokines in obstructive sleep apnea hyponea syndrome with hypertension in a rat model.
|
29215742 |
2018 |
Hypertensive disease
|
0.400 |
Biomarker
|
group |
BEFREE |
Exercise Training Attenuates Hypertension Through TLR4/MyD88/NF-κB Signaling in the Hypothalamic Paraventricular Nucleus.
|
31708733 |
2019 |
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Genetic deletion of toll-like receptor 4 on platelets attenuates experimental pulmonary hypertension.
|
24637196 |
2014 |
Hypertensive disease
|
0.400 |
AlteredExpression
|
group |
BEFREE |
High mobility group box 1 contributes to the pathogenesis of experimental pulmonary hypertension via activation of Toll-like receptor 4.
|
23269975 |
2013 |
Hypertensive disease
|
0.400 |
Biomarker
|
group |
BEFREE |
HMGB1/TLR4 promotes hypoxic pulmonary hypertension via suppressing BMPR2 signaling.
|
30610955 |
2019 |
Hypertensive disease
|
0.400 |
Biomarker
|
group |
BEFREE |
In the present study, we showed that resistin induces hypertension and IR in wild type (WT) mice, but not in tlr4(-/-) mice.
|
26917360 |
2016 |
Hypertensive disease
|
0.400 |
Biomarker
|
group |
BEFREE |
In this review, we discuss the emerging role of TLR4 in the pathogenesis of hypertension and whether targeting this receptor and its signalling pathways could offer a therapeutic strategy for management of this multifaceted disease.
|
29981161 |
2019 |
Hypertensive disease
|
0.400 |
Biomarker
|
group |
BEFREE |
Intermedin in Paraventricular Nucleus Attenuates Sympathoexcitation and Decreases TLR4-Mediated Sympathetic Activation via Adrenomedullin Receptors in Rats with Obesity-Related Hypertension.
|
30276527 |
2019 |
Hypertensive disease
|
0.400 |
Biomarker
|
group |
BEFREE |
One of the possible receptors that could have significant attention in the field of hypertension is toll-like receptor 4 (TLR-4).
|
28386844 |
2017 |
Hypertensive disease
|
0.400 |
Biomarker
|
group |
CTD_human |
Our findings suggest that TLR4/MyD88/NF-κB signaling and PPAR-γ within the PVN are involved in the beneficial effects of telmisartan in hypertension.
|
27292124 |
2016 |
Hypertensive disease
|
0.400 |
Biomarker
|
group |
BEFREE |
Recent studies implicate TLR4 activation and oxidative stress in cardiovascular diseases and also as a link between inflammation and hypertension.
|
28743964 |
2017 |
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The frequency of SNP896A/G in the TLR4 gene was not associated with AMI and arterial hypertension.
|
22229967 |
2012 |
Hypertensive disease
|
0.400 |
Biomarker
|
group |
BEFREE |
The interplay between Angiotensin II, TLR4 and hypertension.
|
28330785 |
2017 |
Hypertensive disease
|
0.400 |
Biomarker
|
group |
BEFREE |
The objective of this study was to define the mechanisms of homocysteine-induced effects on the aortic wall that promote vascular remodeling and hypertension as well as explore the role of Toll-like receptor 4 in homocysteine-induced effects.
|
28665886 |
2017 |
Hypertensive disease
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We hypothesised that variants rs5030717 and rs5030718 of TLR4 are associated with diabetic nephropathy, hypertension and dyslipidaemia.
|
30211669 |
2018 |
Hypertensive disease
|
0.400 |
AlteredExpression
|
group |
BEFREE |
ρ=0.566, P<0.001) whereas in well-controlled patients a correlation was found between hypertension duration and TLR4 expression (ρ=0.322, P=0.020).
|
28359064 |
2017 |