|
Crohn Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Binding of the TLR-4 antibody in patients with active CD was similar to that in controls, while patients in remission had significantly higher binding capacities (P = 0.59 and P = 0.003).
|
27714784 |
2017 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in CARD15 and TLR4 have been linked with Crohn's disease (CD).
|
17504508 |
2007 |
|
Crohn Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Expression of growth-related oncogene-alpha was increased in intestinal TB, while expression of interferon-gamma (IFN-) and TLR 4, 5 and 9 was increased in Crohn's disease.
|
23575333 |
2013 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms of NOD2 (R702W, G908R and L1007fs) and TLR4 (Asp299Gly and Thr399Ile) genes were analyzed in 106 patients with IBD (68 with ulcerative colitis [UC], 38 with Crohn's disease [CD]) and 160 healthy controls using polymerase chain reaction-restriction fragment length polymorphism.
|
29055077 |
2017 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The TLR4 Asp299Gly and Thr399Ile polymorphisms were genotyped and tested for case-control frequency differences in a New Zealand white cohort of 389 Crohn's disease (CD) patients, 405 ulcerative colitis (UC) patients, and 416 population controls.
|
17850411 |
2007 |
|
Crohn Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
The aim of the study was to evaluate associations between inflammatory bowel disease (IBD) presentation and variants in NOD2, TLR4, TNF-α, IL-6, IL-1β, and IL-RN genes in order to identify possible environmental factors that may affect IBD occurrence, investigate potential predictors for surgical treatment of IBD, and correlate the presence of granulomas in biopsy specimens with clinical characteristics of Crohn's disease (CD) patients.
|
28452812 |
2017 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
TLR4 and CD14 variants did not differ between CD and controls.
|
15190267 |
2004 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Furthermore a missense polymorphism in the TLR4 gene has been associated with a number of autoimmune conditions, including Crohn diseases, making TLR4 a viable candidate gene for investigation.
|
26830904 |
2016 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The nucleotide oligomerization domain 2/caspase activating recruitment domain 15 (NOD2/CARD15) gene located at 16q12 is strongly associated with susceptibility to CD in white people but is absent in adult Asian patients, whereas the role of Toll-like receptor 4 (TLR4) polymorphisms has also been reported.
|
17325555 |
2007 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Common NOD2/CARD15 and TLR4 Polymorphisms Are Associated with Crohn's Disease Phenotypes in Southeastern Brazilians.
|
27107867 |
2016 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our meta-analysis suggests that TLR4 T399I polymorphism is moderately associated with susceptibility to CD, and more studies are needed to confirm our conclusion.
|
29421805 |
2018 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the NOD2/caspase recruitment domains 15 (CARD15) and in the Toll-like receptor 4 (TLR4) gene have been associated with increased susceptibility for CD.
|
16148063 |
2005 |
|
Crohn Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
In this study, we aimed to determine whether TLR4 gene was associated with Crohn's disease (CD) and ulcerative colitis (UC) among Moroccan patients, and evaluated its correlation with clinical manifestation of the disease.
|
25492126 |
2014 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We observed that the R702W and 1007fs Nod2 alleles and the A299G Tlr4 alleles were significantly more prevalent in patients with CD as compared to healthy controls or patients with ulcerative colitis.
|
16010583 |
2005 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Toll-like receptor (TLR) polymorphisms, and especially TLR-4 Asp299Gly and TLR-4 Thr399Ile, have been linked with Crohn's disease (CD) and to a lesser extent with ulcerative colitis (UC), CD behavior, and compromised seroreactivity to microbial antigens.
|
22918682 |
2013 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
D299G and T399I were related to CD only in patients carrying NOD2 variants (NOD2+/TLR4+ haplotype) (p=0.036; OR=1.924), increasing the risk to develop CD when 1007insC and TLR4 variants were both present (OR=4.886).
|
27290609 |
2016 |
|
Crohn Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
In addition, interaction of TLR4 with the caspase recruitment domain containing protein 15 gene (CARD15) was studied in patients with Crohn's disease (CD).
|
15905704 |
2005 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, we propose the absence of NOD2/TLR4 cross-tolerance as a central mechanism for the increased susceptibility to Crohn's disease in individuals with NOD2 mutations.
|
18028374 |
2008 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
TLR4 variant D299G showed significant association, with UC (P=0.009) and CD (P=0.039).
|
23470644 |
2013 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To examine whether TLR4 Asp299Gly, CD14-260C/T, TNF-1031T/C, TNF-863C/A, TNF-857C/T, TACE-172C/T, and TACE-154C/A polymorphisms are associated with Crohn disease in the Ashkenazi Jewish population, we analyzed families with at least 1 child with Crohn disease for association with these mutations using a family-based association test (transmission disequilibrium test) for analysis.
|
18493210 |
2008 |
|
Crohn Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Our aim was to investigate whether mutations in various genes other than NOD2/CARD15 or TLR4 associated with CD (NOD1/CARD4, DLG5 and DEFB1) may influence the presence of antibodies against bacterial proteins and carbohydrates in a Hungarian cohort of CD patients.
|
18397186 |
2008 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This genetic study provides evidence that the three major CARD15/NOD2 variant alleles and the CD14 -159C/T polymorphism are associated with Crohn's disease (CD) susceptibility in the Saudi population; however, there is no evidence that the TLR4 (Thr399Il) or CARD15/NOD2 polymorphisms can be considered risk factors for Crohn's disease.
|
22605977 |
2012 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, we identified that TLR4 A299G was associated with CD limited to the colon (P = 0.02).
|
18213697 |
2008 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.
|
24971461 |
2014 |
|
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Nevertheless, the significance of the TLR4 299G and TLR9-1237C associations with CD worldwide was confirmed by a meta-analysis test using our datasets and datasets from previously published studies.
|
17914947 |
2007 |