Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
TLR4 and CD14 variants did not differ between CD and controls.
|
15190267 |
2004 |
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
TLR4 variant D299G showed significant association, with UC (P=0.009) and CD (P=0.039).
|
23470644 |
2013 |
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
D299G and T399I were related to CD only in patients carrying NOD2 variants (NOD2+/TLR4+ haplotype) (p=0.036; OR=1.924), increasing the risk to develop CD when 1007insC and TLR4 variants were both present (OR=4.886).
|
27290609 |
2016 |
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A cohort of 231 Israeli CD patients previously genotyped for the single nucleotide polymorphisms (SNPs) in the CARD15, TLR4 susceptibility genes for CD, was analyzed for the 3'-untranslated region (UTR) SNP of the NFKBIA gene in comparison to 100 healthy ethnically matched controls.
|
17333217 |
2007 |
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
Crohn Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Binding of the TLR-4 antibody in patients with active CD was similar to that in controls, while patients in remission had significantly higher binding capacities (P = 0.59 and P = 0.003).
|
27714784 |
2017 |
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
CD susceptibility polymorphisms ATG16L1 rs2241880, ICAM1 rs5498, IL4 rs2070874, IL17F rs763780, IRGM rs13361189, ITLN1 rs2274910, LRRK2 rs11175593, and TLR4 rs4986790 were genotyped in a Portuguese population (511 CD patients, 626 controls) and assessed for association with CD clinical characteristics.
|
22573572 |
2013 |
Crohn Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Co-localization of iAP with TLR4 showed intense staining with a dotted-like pattern. iAP was present in the inflamed and non-inflamed mucosa of patients with CD, UC, and in control biopsy specimens, irrespective of whether it was present in the terminal ileum or in the colon.
|
22783049 |
2012 |
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Common NOD2/CARD15 and TLR4 Polymorphisms Are Associated with Crohn's Disease Phenotypes in Southeastern Brazilians.
|
27107867 |
2016 |
Crohn Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Expression of growth-related oncogene-alpha was increased in intestinal TB, while expression of interferon-gamma (IFN-) and TLR 4, 5 and 9 was increased in Crohn's disease.
|
23575333 |
2013 |
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Furthermore a missense polymorphism in the TLR4 gene has been associated with a number of autoimmune conditions, including Crohn diseases, making TLR4 a viable candidate gene for investigation.
|
26830904 |
2016 |
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, we identified that TLR4 A299G was associated with CD limited to the colon (P = 0.02).
|
18213697 |
2008 |
Crohn Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Genotype interaction analyses using three different statistical approaches provided significant evidence of interaction for the following combinations: CARD15/TLR4 (CD and UC), CARD15/CD14 (CD and UC), CD14/TLR4 (UC only), and CD14/BPI (UC only).
|
19275920 |
2009 |
Crohn Disease
|
0.500 |
Biomarker
|
disease |
LHGDN |
Hyperexpression of FcgammaRI and TLR4 on MCs was related to the high frequency of TNF-alpha expression in CD, suggesting the activation of MCs via these receptors in vivo.
|
17827066 |
2007 |
Crohn Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
In addition, interaction of TLR4 with the caspase recruitment domain containing protein 15 gene (CARD15) was studied in patients with Crohn's disease (CD).
|
15905704 |
2005 |
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
In addition, interaction of TLR4 with the caspase recruitment domain containing protein 15 gene (CARD15) was studied in patients with Crohn's disease (CD).
|
15905704 |
2005 |
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, we propose the absence of NOD2/TLR4 cross-tolerance as a central mechanism for the increased susceptibility to Crohn's disease in individuals with NOD2 mutations.
|
18028374 |
2008 |
Crohn Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
In contrast, pattern recognition-mediated innate immune pathways (TLR4 and TLR2) were significantly elevated in UC but not in CD.
|
30517639 |
2019 |
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In further exploring the genetic background of these diseases, we investigated the variations in the CARD15/NOD2 gene (Arg702Trp, Gly908Arg and Leu1007fsinsC), and polymorphisms in the TLR4 gene (Asp299Gly and Thr399Ile) as well as in the promoter of the CD14 gene (T/C at position -159) in Greek patients with CD and UC.
|
15655821 |
2005 |
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
In further exploring the genetic background of these diseases, we investigated the variations in the CARD15/NOD2 gene (Arg702Trp, Gly908Arg and Leu1007fsinsC), and polymorphisms in the TLR4 gene (Asp299Gly and Thr399Ile) as well as in the promoter of the CD14 gene (T/C at position -159) in Greek patients with CD and UC.
|
15655821 |
2005 |
Crohn Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
In this study, we aimed to determine whether TLR4 gene was associated with Crohn's disease (CD) and ulcerative colitis (UC) among Moroccan patients, and evaluated its correlation with clinical manifestation of the disease.
|
25492126 |
2014 |
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In this two-center, retrospective German and Hungarian cohort study, patients with Crohn's disease (CD) (n = 379; German n = 235, Hungarian n = 144) and ulcerative colitis (UC) (n = 263; German n = 145, Hungarian n = 118) and healthy controls (n = 605; German n = 403, Hungarian n = 202) were genotyped for the presence of the CD14 c.1-260C>T promoter variant and the TLR4 c.896A>G (p.D299G) variant by melting curve analysis using fluorescence resonance energy transfer probes.
|
18174680 |
2007 |
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Interestingly, TLR4 Asp299Gly polymorphism was significantly associated with increased risk of CD and UC in all genetic models, except for the additive one in CD.
|
26023918 |
2015 |
Crohn Disease
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Let-7b ameliorates Crohn's disease-associated adherent-invasive E coli induced intestinal inflammation via modulating Toll-Like Receptor 4 expression in intestinal epithelial cells.
|
30142321 |
2018 |
Crohn Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the NOD2/caspase recruitment domains 15 (CARD15) and in the Toll-like receptor 4 (TLR4) gene have been associated with increased susceptibility for CD.
|
16148063 |
2005 |