TLR4, toll like receptor 4, 7099

N. diseases: 1174; N. variants: 54
Disease: Acanthamoeba Keratitis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0000880
Disease: Acanthamoeba Keratitis
Acanthamoeba Keratitis 		0.220 AlteredExpression disease BEFREE The aim of this study was to determine for the first time the expression of TLR2 and TLR4 in the lung of Acanthamoeba spp. infected mice using quantitative real-time polymerase chain reaction (Q-PCR) and immunohistochemical (IHC) staining.The Acanthamoeba spp. were isolated from a patient with Acanthamoeba keratitis (AK) (strain Ac 55) and from environmental samples of water from Malta Lake (Poznań, Poland - strain Ac 43). 26940205 2016
CUI: C0000880
Disease: Acanthamoeba Keratitis
Acanthamoeba Keratitis 		0.220 Biomarker disease BEFREE Results suggest that pathogenic species of Acanthamoeba activate TLR4 and induce production of CXCL2 in the Chinese hamster model of AK. 24633052 2014
CUI: C0000880
Disease: Acanthamoeba Keratitis
Acanthamoeba Keratitis 		0.220 Biomarker disease RGD Toll-like receptor 4 signalling pathway activation in a rat model of Acanthamoeba Keratitis. 21155840 2011