Colitis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Regulatory DCs in Galectin-3:Toll-like receptor-4:Kynurenine-dependent manner promoted the expansion of colon-infiltrated T regulatory cells (Tregs) and suppressed Th1 and Th17 cell-driven colon inflammation.
|
31336879 |
2019 |
Colitis
|
0.300 |
Biomarker
|
disease |
BEFREE |
In addition, we found that the canonical signaling downstream of TLR4 was activated in 2,4,6-trinitrobenzene sulfate-induced colitis in the wild type but not in the TLR4-deficient mice.
|
30672380 |
2019 |
Colitis
|
0.300 |
Biomarker
|
disease |
BEFREE |
TLR4 and NF-κB in the therapy group were positively correlated with TNF-α mRAN (<i>P</i> < 0.050).Conclusion: In conclusion, probiotic VSL#3 inhibits the expression of NF-κB and TNF-α in rats with colitis through TLR4-NF-κB signal pathway, so it is expected to be a first choice drug for the treatment of colitis.
|
31497551 |
2019 |
Colitis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
These findings indicate that core fucose is essential for CD14-dependent TLR4 and TLR2 signalling in murine macrophage activity, leading to DSS-induced experimental colitis.
|
30445455 |
2019 |
Colitis
|
0.300 |
Biomarker
|
disease |
BEFREE |
In the second experiment, there were three groups: i) Group A1, control C57BL/6 mice; ii) group B1, E. coli‑treated DSS‑induced colitis BD C57BL/6 mice; and iii) E. coli‑treated DSS‑induced colitis BD TLR4‑/‑ mice.
|
30664156 |
2019 |
Colitis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Although oral administration of IAP significantly attenuated the severity of colitis in both preventive and therapeutic models of WT mice, these protective effects were not significant in TLR4<sup>-/-</sup> mice.
|
29247612 |
2018 |
Colitis
|
0.300 |
Biomarker
|
disease |
BEFREE |
The Anti-Inflammatory Effect and Intestinal Barrier Protection of HU210 Differentially Depend on TLR4 Signaling in Dextran Sulfate Sodium-Induced Murine Colitis.
|
27995407 |
2017 |
Colitis
|
0.300 |
Biomarker
|
disease |
BEFREE |
In order to investigate the Toll-like receptor-2 (TLR2), TLR4, and interleukin 10 (IL-10) molecular signaling pathways involved in BF-mediated prevention of dextran sulfate sodium (DSS)-induced colitis.
|
28683149 |
2017 |
Colitis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Intervention of Isomaltodextrin Mitigates Intestinal Inflammation in a Dextran Sodium Sulfate-Induced Mouse Model of Colitis via Inhibition of Toll-like Receptor-4.
|
28102669 |
2017 |
Colitis
|
0.300 |
Biomarker
|
disease |
BEFREE |
In conclusion, oral administration of ML attenuated colitis in mice by inhibiting the binding of LPS to TLR4 on immune cells and increasing the polarization of M1 macrophages to M2 macrophages.
|
28189973 |
2017 |
Colitis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Taken together, the results suggest that the TLR4-Blimp-1 axis promotes DSS induced experimental colitis through the down-regulation of NLRP12.
|
27105524 |
2016 |
Colitis
|
0.300 |
Biomarker
|
disease |
BEFREE |
We found that EPS specifically bind peritoneal macrophages, and because mice lacking MyD88 signaling in myeloid cells were not protected by EPS, we conclude that bacterial EPS prevent colitis in a TLR4-dependent manner that requires myeloid cells.
|
24740503 |
2014 |
Colitis
|
0.300 |
Biomarker
|
disease |
BEFREE |
In this study, we investigated the involvement of NO production in activation of the TLR4/NF-κB signaling pathway in mice with DSS-induced colitis.
|
24992835 |
2014 |
Colitis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Readressing the role of Toll-like receptor-4 alleles in inflammatory bowel disease: colitis, smoking, and seroreactivity.
|
22918682 |
2013 |
Colitis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In human UC samples, TLR4 expression was upregulated in almost all colitis-associated cancer and progressively increased with grade of dysplasia.
|
21674704 |
2011 |
Colitis
|
0.300 |
Biomarker
|
disease |
RGD |
In this study, we investigated the effects of curcumin on the expression of TLR-4 and MyD88, the upstream signaling pathway in experimental colitis induced in the Sprague-Dawley male rats by intra-rectal administration of trinitrobenzenesulfonic acid (TNBS).
|
19002562 |
2009 |
Colitis
|
0.300 |
Biomarker
|
disease |
BEFREE |
The main aims of this study is to evaluate effects of intraperitoneal injection recombinant human TFF3 on the expression of tumour necrosis factor alpha (TNF-alpha), toll-like receptor 4(TLR4), and nuclear factor kappaB (NF-kappaB) in trinitrobenzene sulphonic acid (TNBS) induced colitis mice.
|
19238529 |
2009 |
Colitis
|
0.300 |
Biomarker
|
disease |
BEFREE |
These data demonstrate that lack of IL-10 had a greater effect on C. jejuni induced colitis than other immune elements such as TLR4 (C3H/HeJ, C3Bir IL-10(-/-)), MHC H-2g7, diabetogenic genes, and CTLA-4 (NOD) and that host genetic background is in part responsible for disease phenotype.
|
18586081 |
2008 |
Colitis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Because knowledge on shifts in the intestinal microflora during colitis is limited, we performed a global survey of the colon flora of C57BL/10 wild-type (wt), TLR2(-/-), TLR4(-/-), and TLR2/4(-/-) mice treated for seven days with 3.5% dextrane-sulfate-sodium (DSS).
|
17653282 |
2007 |
Colitis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
We recently showed that mice deficient in Toll-like receptor 4 (TLR4) or its adapter molecule MyD88 have increased signs of colitis compared with wild-type (WT) mice after dextran sodium sulfate (DSS)-induced injury.
|
16952555 |
2006 |
Colitis
|
0.300 |
Biomarker
|
disease |
BEFREE |
In conclusion, our data provide evidence that E. coli Nissle 1917 ameliorates experimental induced colitis in mice via TLR-2- and TLR-4-dependent pathways.
|
16790781 |
2006 |
Colitis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Toll-like receptor 4 contributes to colitis development but not to host defense during Citrobacter rodentium infection in mice.
|
16622187 |
2006 |