Ulcerative Colitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
In this study, increased expression of PTPRO, toll-like receptor (TLR4) and inflammatory cytokines were observed in mucosal tissues (MTs) from inflamed areas and lamina propria mononuclear cells (LPMCs) of patients with UC compared with those from healthy controls.
|
31452237 |
2020 |
Ulcerative Colitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to investigate the regulatory mechanism of mesalazine (MSLZ) on microRNA-21, microRNA-31 and Toll-like receptor 4/myeloid differentiation primary response 88 (TLR4/MyD88)-dependent pathway in 2,4,6-trinitrobenzene sulfonic acid (TNBS)/ethanol-induced ulcerative colitis (UC) model in mice.
|
31378906 |
2019 |
Ulcerative Colitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
MiR-146a regulates the development of ulcerative colitis via mediating the TLR4/MyD88/NF-κB signaling pathway.
|
30915760 |
2019 |
Ulcerative Colitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
In contrast, pattern recognition-mediated innate immune pathways (TLR4 and TLR2) were significantly elevated in UC but not in CD.
|
30517639 |
2019 |
Ulcerative Colitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
ANRIL/miR-323b-5p/TLR4/MyD88/NF-κB pathway may provide a new strategy for UC therapy.
|
30477744 |
2019 |
Ulcerative Colitis
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Western blotting and reverse transcription‑quantitative polymerase chain reaction analysis were used to detect the levels of cytokines associated with UC and proteins associated with Toll‑like receptor 4 (TLR4)‑nuclear factor (NF)‑κB pathway.
|
31173225 |
2019 |
Ulcerative Colitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
To investigate the effects and the underlying mechanism of HU210 action on the UC in relation to a role of TLR4 and MAP kinase signaling.
|
27995407 |
2017 |
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms of NOD2 (R702W, G908R and L1007fs) and TLR4 (Asp299Gly and Thr399Ile) genes were analyzed in 106 patients with IBD (68 with ulcerative colitis [UC], 38 with Crohn's disease [CD]) and 160 healthy controls using polymerase chain reaction-restriction fragment length polymorphism.
|
29055077 |
2017 |
Ulcerative Colitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
EGCG can inhibit the intestinal inflammatory response by reducing the severity of ulcerative colitis and maintaining the Th1/Th2 balance through the TLR4/MyD88/NF-<i>κ</i>B signaling pathway.
|
29404307 |
2017 |
Ulcerative Colitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
All-Trans Retinoic Acid Modulates TLR4/NF-<i>κ</i>B Signaling Pathway Targeting TNF-<i>α</i> and Nitric Oxide Synthase 2 Expression in Colonic Mucosa during Ulcerative Colitis and Colitis Associated Cancer.
|
28408791 |
2017 |
Ulcerative Colitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Of the six TLRs (TLRs 1, 2, 4, 5, 6 and 9) examined, only TLR-4 was increased significantly in IBD, specifically in active UC.
|
26462859 |
2016 |
Ulcerative Colitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
To investigate whether variants in NOD2/CARD15 and TLR4 are associated with CD and ulcerative colitis (UC) in a genetically admixed population of Rio de Janeiro, where IBD has continued to rise.
|
27107867 |
2016 |
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
Ulcerative Colitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
These data support essential roles of stasis-induced, colon-like microbiota, TLR4-mediated colonic metaplasia, and genetic susceptibility in the development of pouchitis and possibly UC.
|
27079612 |
2016 |
Ulcerative Colitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
The patients with CD were characterized by a significantly higher monocyte basal expression of TNF-α compared with healthy subjects and UC patients, and after stimulation with Pam<sub>3</sub>CSK<sub>4</sub> (ligand of TLR2/1) and MDP-L18 (ligand of NOD2) this difference was maintained, while other microbial stimuli (LPS, ligand of TLR4 and PolyI:C, ligand of TLR3) induced massive activation in CD monocytes as well as in UC and in healthy control cells.
|
27895399 |
2016 |
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Significant associations were found between Crohn's disease (CD) and minor NOD2 variants, as well as TLR4 299Gly, TNF-α G-308A, IL-6 G-174C and IL-1RN VNTR A2 variants, while ulcerative colitis (UC) was associated only with IL-1RN VNTR A2 variants.
|
26316104 |
2015 |
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Interestingly, TLR4 Asp299Gly polymorphism was significantly associated with increased risk of CD and UC in all genetic models, except for the additive one in CD.
|
26023918 |
2015 |
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).
|
24776844 |
2014 |
Ulcerative Colitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
In this study, we aimed to determine whether TLR4 gene was associated with Crohn's disease (CD) and ulcerative colitis (UC) among Moroccan patients, and evaluated its correlation with clinical manifestation of the disease.
|
25492126 |
2014 |
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.
|
24971461 |
2014 |
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Despite the mutant TLR-4 predisposition for UC pancolitis, smoking was associated with more limited disease (P < 0.001).
|
22918682 |
2013 |
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
IRF5, but not TLR4, DEFB1, or VDR, is associated with the risk of ulcerative colitis in a Han Chinese population.
|
23971939 |
2013 |
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
TLR4 variant D299G showed significant association, with UC (P=0.009) and CD (P=0.039).
|
23470644 |
2013 |
Ulcerative Colitis
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Polymorphisms in CD14-159C > T and TLR4-299A > G significantly affected mCD14 and mTLR4 expression levels and also increased susceptibility to UC.
|
22192785 |
2012 |
Ulcerative Colitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Overall, no heterozygous or homozygous single nucleotide polymorphism mutations were found in patients with Crohn's disease and ulcerative colitis both in the TLR4 gene Asp299Gly, Thr399Ile and the TLR2 gene Arg677Trp, Arg753Gln in the Zhuang population from the Guangxi Zhuang Autonomous Region of China.
|
23239925 |
2012 |