|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Diabetes was induced in wild type (WT) and TLR4 knockout (KO) C57BL/6 mice by intraperitoneal injection of low dose streptozocin (STZ).
|
31732468 |
2020 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
This suggests that inhibition of vascular TLR-4 may provide therapeutic benefits for stroke recovery in diabetes.
|
29909454 |
2019 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Toll-like receptor 4 (TLR4) activation contributes to vascular dysfunction in pathological conditions such as hypertension and diabetes, but the role of chronic TLR4 activation on renal autoregulatory behavior is unknown.
|
31432707 |
2019 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
HMGB1/TLR4 promotes apoptosis and reduces autophagy of hippocampal neurons in diabetes combined with OSA.
|
31678553 |
2019 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this work, the interplay between TLR4 and HSP70 in the vasculature during diabetes is reviewed and discussed.
|
30129410 |
2019 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data reveal a regulatory mechanism controlling the proliferation of β cells in diet-induced obesity and suggest that selective targeting of the TLR2/TLR4 pathways may reverse β cell failure in patients with diabetes.
|
31110312 |
2019 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
In obesity, the amplified TLR4 response may potentiate β-cell damage and accelerate diabetes progression.
|
30287405 |
2019 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
The Toll-like receptor 4 (TLR4) regulates inflammatory responses in several pathological conditions including diabetes and OA.
|
30953645 |
2019 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Fibronectin splicing variant containing extra domain A (Fn-EDA), which is an endogenous ligand for Toll-like receptor 4 (TLR4), is present in negligible amounts in the plasma of healthy humans, but markedly elevated in patients with co-morbid conditions including diabetes and hyperlipidaemia, which are risk factors for myocardial infarction (MI).
|
29960272 |
2018 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Clinical evidence also supports increased ligands and TLR2 and TLR4 expression in diabetes however there are no clinical studies examining whether interruption of these pathways confer renoprotection.
|
29059081 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Toll-like receptor 4 (TLR4) contributes to inflammation, and it has been implicated in diabetes pathophysiology.
|
30171701 |
2018 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We also found that prevalence of A/G genotype of TLR4 rs4986790 and CT genotype of TLR4 rs4986791 are significantly higher in patients of diabetes with UTI in comparison to diabetic patients without UTI.
|
29066305 |
2018 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Although there was no overall difference in the genotype frequencies of TLR4 rs5030717 in diabetes v controls, the genotype frequencies of diabetic dyslipidaemia cases compared with controls were different (p = 0.001).
|
30211669 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Macrophage activation mediated by TLR4-JNK signaling plays an important role during the progress of diabetes.
|
29850615 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
A syngeneic transplant model using a marginal mass of islets transplanted intraportally into mice with streptozotocin-induced diabetes was used to study transplant outcomes after early TLR4 blockade.
|
29787520 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
To investigate whether pharmacological blockade of TLR4 affects erectile function in a murine model of diabetes.
|
30145096 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, UA alleviates inflammation and inhibits diabetes‑induced nephropathy through a TLR4‑mediated inflammatory pathway.
|
30221655 |
2018 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Overall, available data indicate that the upregulated TLR4 response in the kidney translates the metabolic alterations of diabetes into kidney damage.
|
28933050 |
2017 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In summary, contrary to hundred-year-old postulations about immune suppression in diabetic hosts, we find that diabetes instead predisposes to more severe infections because of additional inflammatory output through dual activation of MyD88 by not only TLR4 but also RAGE.
|
28830942 |
2017 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have previously reported that toll-like receptor 4 (TLR4) is involved in retinal damage in diabetes.
|
29490521 |
2017 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Since reduced HMGB1 binds to RAGE but not to TLR4, redox modification of HMGB1 as a mechanism regulating the cross-talk between apoptosis and autophagy in diabetes is discussed.
|
28695466 |
2017 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
TLR4 is a link between diabetes and Alzheimer's disease.
|
27591966 |
2017 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Expressional levels of HSP27, HSP47 and HSP70 and their downstream molecules like TLR4, p38-MAPK were seen in biopsies from 101 human diabetic wounds compared to 8 control subjects without diabetes using RT-PCR, western blot and immunohistochemistry.
|
25746357 |
2016 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Innate immune system activation via Toll-like receptor 4 (TLR4) leads to inflammation and oxidative stress and was implicated in diabetes pathophysiology.
|
27650857 |
2016 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Expression changes in HMGB1 and TLR4 were detected throughout the course of diabetes.
|
22217446 |
2012 |