|
Myocardial Infarction
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Moreover, a significant upregulation of gene and protein expressions of HMGB1 and its related TLR4 and NF-κB were observed in the MI group when compared with the sham group.
|
31280453 |
2019 |
|
Myocardial Infarction
|
0.200 |
Biomarker
|
disease |
BEFREE |
TLR4 knockdown also exhibited a lower arrhythmia score following programmed electrical stimulation than those treated with MI surgery only, indicating that the knockdown of TLR4 decreased the incidence of malignant ventricular arrhythmias following MI.
|
30978539 |
2019 |
|
Myocardial Infarction
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
AMI mice in the Perindopril group had decreased expression levels of Bax protein and TLR4 and NF-κB p50 mRNA and protein, as well as the Bax/Bcl-2 ratio.
|
31378910 |
2019 |
|
Myocardial Infarction
|
0.200 |
Biomarker
|
disease |
BEFREE |
This study aimed to verify the effect of thyroid hormones on the TLR4/NF-κβ pathway after myocardial infarction.
|
28888669 |
2018 |
|
Myocardial Infarction
|
0.200 |
Biomarker
|
disease |
BEFREE |
Isoquercetin ameliorates myocardial infarction through anti-inflammation and anti-apoptosis factor and regulating TLR4-NF-κB signal pathway.
|
29532872 |
2018 |
|
Myocardial Infarction
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Fluvastatin can inhibit myocardial infarction and decrease cardiomyocyte apoptosis by increasing the expression of TLR4-like receptor.
|
30116385 |
2018 |
|
Myocardial Infarction
|
0.200 |
Biomarker
|
disease |
BEFREE |
Tanshinone IIA prevents left ventricular remodelling via the TLR4/MyD88/NF-κB signalling pathway in rats with myocardial infarction.
|
29524303 |
2018 |
|
Myocardial Infarction
|
0.200 |
Biomarker
|
disease |
BEFREE |
We reproduced a model of MI by the permanent ligation of the left anterior descending coronary artery of Tlr4-knockout (Tlr4<sup>-/-</sup>) and wild-type (WT) male mice.
|
30399463 |
2018 |
|
Myocardial Infarction
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
PBMCs were presented as TLR2 expression or TLR4 expression using flow cytometry.From mRNA to protein detection, PBMC TLR2 and TLR4 were significantly higher in the AFMI group than in the control group and MI group.
|
29375116 |
2018 |
|
Myocardial Infarction
|
0.200 |
Biomarker
|
disease |
BEFREE |
Fibronectin splicing variant containing extra domain A (Fn-EDA), which is an endogenous ligand for Toll-like receptor 4 (TLR4), is present in negligible amounts in the plasma of healthy humans, but markedly elevated in patients with co-morbid conditions including diabetes and hyperlipidaemia, which are risk factors for myocardial infarction (MI).
|
29960272 |
2018 |
|
Myocardial Infarction
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In summary, the present meta-analysis indicated that the TLR4 gene Asp299Gly polymorphism was not associated with MI risk.
|
24269693 |
2014 |
|
Myocardial Infarction
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Carriers of TLR4 polymorphisms with a history of myocardial infarction (n = 573) had lower platelet counts than those with the wild-type genotype (217 +/- 7 vs. 237 +/- 2.8; p = 0.021).
|
20237756 |
2010 |
|
Myocardial Infarction
|
0.200 |
Biomarker
|
disease |
BEFREE |
We investigated independent and joint associations of variations in cholesterol ester transfer protein (CETP), interleukin-8 (IL8), peroxisome proliferator activator receptor-alpha (PPARA), and Toll-like receptor 4 (TLR4) genes with incident nonfatal myocardial infarction (MI) or ischemic stroke.
|
18549840 |
2008 |
|
Myocardial Infarction
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
In the infarcted area, the heat shock protein 70, TLR2 and TLR4, and IFN-gamma expression were reduced in MI-G, but increased in MI-GM in comparison with those in MI-C animals.
|
18832728 |
2008 |
|
Myocardial Infarction
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
However, current data indicate that screening for interleukin (IL)-6, IL-10, TLR4, CCR5, COX and LOX polymorphisms are likely to be a useful tool for CHD and MI risk assessment.
|
18220812 |
2007 |
|
Myocardial Infarction
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Despite sufficient statistical power to replicate the findings observed in the South Italians, our results rule out a noteworthy influence of the TLR4 polymorphism upon human longevity or MI in German men.
|
17493663 |
2007 |
|
Myocardial Infarction
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In a previous study, the +896G TLR4 allele was overrepresented in advanced age men and underrepresented in men affected by myocardial infarction.
|
16388712 |
2006 |
|
Myocardial Infarction
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Toll-like receptor 4 polymorphism is associated with coronary stenosis but not with the occurrence of acute or old myocardial infarctions.
|
17101559 |
2006 |
|
Myocardial Infarction
|
0.200 |
AlteredExpression
|
disease |
LHGDN |
HSP70 levels were positively correlated with monocyte TLR4, plasma interleukin-6 and tumor necrosis factor-alpha levels in AMI patients.
|
16714144 |
2006 |
|
Myocardial Infarction
|
0.200 |
Biomarker
|
disease |
BEFREE |
In this paper we review the evidence for a possible role of genetic polymorphisms of the most important inflammatory cytokines (IL-6, TNF-alpha, IL-10) and immune receptors (CD14 receptor and TLR-4) in modulating the incidence or the prognosis of MI, with a special focus in ageing population.
|
16516951 |
2006 |
|
Myocardial Infarction
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The results indicate that the 896A/G and 1196C/T polymorphisms of the TLR4 gene or haplotypes based on these polymorphisms are not associated with MI.
|
16954131 |
2006 |
|
Myocardial Infarction
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We demonstrated that TLR4 ASP299GLY polymorphism shows a significantly lower frequency in patients affected by myocardial infarction compared to controls, whereas centenarians show a higher frequency.
|
16803999 |
2006 |
|
Myocardial Infarction
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In contrast to previous data, the D299G TLR4 polymorphism was not associated with risk of incident MI or stroke in this large prospective study of US men.
|
15576653 |
2005 |
|
Myocardial Infarction
|
0.200 |
AlteredExpression
|
disease |
LHGDN |
Expansion of circulating Toll-like receptor 4-positive monocytes in patients with acute coronary syndrome.
|
15883205 |
2005 |
|
Myocardial Infarction
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We studied the TLR4 gene Asp299Gly polymorphism in relation to susceptibility to myocardial infarction in a cohort of patients with angiographically documented coronary artery disease, and performed a meta-analysis using data sets from three independent studies.
|
15864121 |
2005 |