|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Studies showed that TLR4 knockout (TLR4<sup>KO</sup>) could mitigate obesity and insulin resistance induced by high-fat diet in rats.
|
31598849 |
2020 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
In this situation, fatty acids cause inflammation via TLR4 (toll like receptor 4) and the nuclei become less responsive to the hormones leptin and insulin, contributing to the development of obesity.
|
31726089 |
2020 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Our finding suggests a compensatory genetic interaction between TLR2 and TLR4 in the context of prenatal inflammatory stimulation, and this interaction likely contributes to the prenatal inflammation-induced hyperlipidemia and lipid overload-induced obesity, thus providing a potential mechanism for the fetal origin of adult metabolic diseases.
|
31507457 |
2019 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Green Tea Extract Treatment in Obese Mice with Nonalcoholic Steatohepatitis Restores the Hepatic Metabolome in Association with Limiting Endotoxemia-TLR4-NFκB-Mediated Inflammation.
|
31574193 |
2019 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Resveratrol inhibits the development of obesity-related osteoarthritis via the TLR4 and PI3K/Akt signaling pathways.
|
30922122 |
2019 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Toll-like-receptor 4 is shown to be involved in ob-ASC-mediated-IL-17A secretion, and to be inhibited by ALA, together with Cyclo-Oxygenase-2 and Signal-Transducer-and-Activator-of-transcription-3.
|
30848861 |
2019 |
|
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
These data suggest that GTE protects against diet-induced obesity consistent with a mechanism involving the gut-adipose axis that limits endotoxin translocation and consequent adipose TLR4/NFκB inflammation by improving gut barrier function.
|
30856467 |
2019 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Resistin promotes hypothalamic neuroinflammation and insulin resistance through Toll like receptor 4 (TLR4), this hormone is thought to be a link between obesity and insulin-resistance.
|
30845245 |
2019 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
In PCOS, lipid-induced LPS-mediated inflammation through TLR-4 is associated with obesity and worsened by PCOS, whereas lipid-induced increases in SOCS-3 may represent an obesity-independent, TNFα-mediated mechanism of IR.
|
30590569 |
2019 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
These are new findings indicating that the MD2-TLR4 immune signaling complex is a critical pathogenic factor in the development of kidney disease related to obesity or metabolic syndrome.
|
31151053 |
2019 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Collectively, we demonstrated that inflammatory response to obesity, such as TLR4 and NLRP3 inflammasome activation as well as IL-1β secretion, attenuates β3-adrenoreceptor-induced beige adipocyte formation via oxidative stress and mitochondrial dysfunction.
|
29264745 |
2018 |
|
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Remarkably, HCC patients with high tumoral TLR4 mRNA expression were more likely to be diagnosed with NAFLD and obese.
|
30034633 |
2018 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Overall, our findings support a model in which elevated FFAs in obesity create a milieu for TNF-α to trigger CCL2 production via the TLR4/TRIF/IRF3 signaling cascade, representing a potential contribution of FFAs to metabolic inflammation.
|
29632147 |
2018 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Bone marrow lympho-myeloid malfunction in obesity requires precursor cell-autonomous TLR4.
|
29453396 |
2018 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Elevated plasma statured fatty acids (FFAs) cause TLR4/MD2 activation-dependent inflammation and insulin tolerance, which account for the occurrence and development of obesity.
|
29667734 |
2018 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
The potential contribution of TLR4 pathways in mediating adverse neural outcomes of obesity has not been well addressed.
|
30396359 |
2018 |
|
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The innate immune Toll-like receptors (TLR) such as TLR2 and TLR4 have emerged as key players in metabolic inflammation; nonetheless, TLR10 expression in the adipose tissue and its significance in obesity/T2D remain unclear.
|
29428931 |
2018 |
|
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
It is concluded that the expression levels of TLR4 and TRIF as well as serum IFNβ and LBP are more related to abdominal obesity than to metabolic health.
|
29914624 |
2018 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
We investigated the effects of berberine on obesity and insulin resistance by examining the lipopolysaccharide (LPS)/toll-like receptor 4 (TLR4)/tumor necrosis factor (TNF)-α signaling pathway in livers of HFD-fed obese rats.
|
29365334 |
2018 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Resistance exercise reduced TLR4 protein in the OB group at 300 min (EX vs. CON leg in OB: P = 0.04).
|
30113718 |
2018 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Obesity primes myeloid cell production from hematopoietic stem cells (HSCs) and Toll-like receptor 4 (TLR4), and the downstream TIR domain-containing adapter protein-inducing interferon-β (TRIF)- and MyD88-mediated pathways regulate production of similar myeloid cells after lipopolysaccharide stimulation.
|
29636416 |
2018 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to evaluate the influence of type 2 diabetes and obesity in the TLR4 pathway in rat neutrophils.
|
30510205 |
2018 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
TLR4 is associated with chronic inflammation in obesity.
|
27714571 |
2017 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
TLR2 and TLR4 downward signaling causes the production of proinflammatory cytokines that can induce insulin resistance and cardiovascular damage in obesity and type 2 diabetes mellitus.
|
28933050 |
2017 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
A possible mediator accounting for obesity-associated inflammation and insulin resistance is Toll-like receptor 4 (TLR4).
|
28323977 |
2017 |