Ankylosing spondylitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
By gene expression and western blot analyses, we found that both TLR3 and TLR4 in AS-MSCs to be downregulated when compared with MSCs derived from healthy donors (HDs).
|
31456484 |
2019 |
Ankylosing spondylitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to investigate the clinical characteristics and frequency of TLR4 polymorphisms (Asp299Gly and Thr 399Ile) in a cohort of Brazilian patients with AS.
|
27692393 |
2018 |
Ankylosing spondylitis
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
Ankylosing spondylitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Gene Expression Profiling of Toll-Like Receptor 4 and 5 in Peripheral Blood Mononuclear Cells in Rheumatic Disorders: Ankylosing Spondylitis and Rheumatoid Arthritis.
|
26996117 |
2016 |
Ankylosing spondylitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The present study might suggest that TLR4 D299G/T399I polymorphisms are not associated with RA/AS susceptibility.
|
22717291 |
2012 |
Ankylosing spondylitis
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
PBC gene expression profiling in AS shows an upregulation of TLR4 and TLR5.
|
20952467 |
2011 |
Ankylosing spondylitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We have recently found evidence of an important role for TLR4 in experimental reactive arthritis, raising the question to be addressed whether genetic polymorphisms in TLR4 affects susceptibility to AS.
|
18034244 |
2008 |
Ankylosing spondylitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
CD14 and TLR4 showed an association with AS in the Finns only.
|
18634146 |
2008 |
Ankylosing spondylitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Given the functional role of TLR4 variants in the innate immune system, larger studies are now warranted to elucidate the association of TLR4 variants in AS.
|
17143969 |
2007 |
Ankylosing spondylitis
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
The results indicated that TLR4 protein and mRNA levels were significantly higher in AS patients than in healthy controls; however, there was no significant difference between human leucocyte antigen (HLA)-B27-positive and -negative AS patients, as well as serum levels of TNF-alpha, IL-12 and sTRAIL.
|
17459079 |
2007 |
Ankylosing spondylitis
|
0.200 |
GeneticVariation
|
disease |
LHGDN |
Association of toll-like receptor 4 variants and ankylosing spondylitis: a case-control study.
|
17143969 |
2007 |
Ankylosing spondylitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms do not contribute to disease susceptibility in either AS or ReA.
|
16567359 |
2006 |
Ankylosing spondylitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
To compare the frequency of two common and functional TLR4 mutations (Asp299Gly, and Thr399Ile) between patients with AS and HLA-B27 healthy controls.
|
16837493 |
2006 |
Ankylosing spondylitis
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
No evidence for involvement of the Toll-like receptor 4 (TLR4) A896G and CD14-C260T polymorphisms in susceptibility to ankylosing spondylitis.
|
15647432 |
2005 |
Ankylosing spondylitis
|
0.200 |
Biomarker
|
disease |
BEFREE |
Between adaptive and innate immunity: TLR4-mediated perforin production by CD28null T-helper cells in ankylosing spondylitis.
|
16277694 |
2005 |