|
Chronic Periodontitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Three SNPs of TLR4, i.e., rs1927911 (TT/CC+CT), rs2149356 (TT/GG+GT) and rs2737190 (GG/AA+AG), were associated with moderate/severe chronic periodontitis in Chinese population infected with <i>P. gingivalis</i>.<i>P. gingivalis</i>, which interacted with TLR4 gene plays an important role in the pathogenesis of periodontitis.
|
31772831 |
2019 |
|
Chronic Periodontitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression of Toll‑like receptor 4 on mast cells in gingival tissues of human chronic periodontitis.
|
29488617 |
2018 |
|
Chronic Periodontitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our meta-analysis showed statistically significant association between TLR4 Asp299Gly allele and increased susceptibility to chronic periodontitis.
|
26771980 |
2016 |
|
Chronic Periodontitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
TLR4 Asp299Gly polymorphism may be protective against chronic periodontitis.
|
26174031 |
2016 |
|
Chronic Periodontitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, TLR4 gene polymorphism plays a role in the common pathophysiology of CP and COPD, indicating that CP patients with TLR4 gene rs1927907 polymorphism may be more susceptible to COPD.(J Oral Sci 58, 555-560, 2016).
|
28025440 |
2016 |
|
Chronic Periodontitis
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
TLR2 and TLR4 gene promoter methylation status during chronic periodontitis.
|
21899586 |
2011 |
|
Chronic Periodontitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In the pooled analysis, the TLR4 299Gly allele (TLR4+896 A>G) appeared to be a genetic risk factor for susceptibility to chronic periodontitis with a random effects and fixed effects odds ratio (OR) of 1.43 [95% confidence interval (CI):1.04-1.97; p=0.03].
|
19426173 |
2009 |
|
Chronic Periodontitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The results did not show that IL-18 and TLR4 variants have an effect on the susceptibility to chronic periodontitis.
|
19811440 |
2009 |
|
Chronic Periodontitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, TLR4 gene polymorphisms were not significantly associated with the susceptibility to, or severity of, chronic periodontitis in our population.
|
17559631 |
2007 |
|
Chronic Periodontitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this case-control study, the association of TLR2 and TLR4 gene polymorphisms with chronic periodontitis (CP) was investigated.
|
17555409 |
2007 |
|
Chronic Periodontitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
No differences were found in the prevalence of the TLR4 Asp299Gly genotype in men with CP (18.9%) compared with an age-matched control group with no evidence of periodontitis (17%).
|
17309585 |
2007 |
|
Chronic Periodontitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Chronic periodontal disease is associated with single-nucleotide polymorphisms of the human TLR-4 gene.
|
15875057 |
2005 |
|
Chronic Periodontitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
CD14 and TLR4 gene polymorphisms in adult periodontitis.
|
16246938 |
2005 |
|
Chronic Periodontitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Using single-immunoenzyme labeling, we show that the human oral mucosa (gingiva) is infiltrated by large numbers of TLR2(+) and TLR4(+) cells and that their numbers increase significantly in CP, relative to health (P < 0.05, Student's t test).
|
15664906 |
2005 |