TLR4, toll like receptor 4, 7099
N. diseases: 1174; N. variants: 54
Source: ALL
Disease | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year |
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0.100 | Biomarker | disease | BEFREE | Strain-specific transcriptomics suggested virus-responsive (<i>Oasl1</i>, <i>Irg1</i>, <i>Mx1</i>) and epidermal differentiation complex (<i>Krt4</i>, <i>Lce3a</i>) genes may contribute to TLR4-independent defense against RSV in resistant strains including C57BL/6J. | 31736414 | 2019 |
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0.100 | Biomarker | disease | BEFREE | The results indicated that TLR4 and C23 gene knockdown decreased the amount of F protein in RSV-infected N2a cells, inhibited RSV propagation, attenuated N2a neuronal injury, diminished cell apoptosis levels, downregulated TLR3 and TLR7 protein expression, and reduced inflammatory protein expression. | 31081244 | 2019 |
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0.100 | Biomarker | disease | BEFREE | The pathogenesis of respiratory syncytial virus (RSV) and influenza A virus (IAV) have been linked to TLR4 activation, and we examined the action of POPG and PI as potential antagonists of the pathology of these viruses. | 30733339 | 2019 |
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0.100 | Biomarker | disease | BEFREE | The potential interaction of RSV F protein with TLR4 and nucleolin was examined by coimmunoprecipitation. | 29427996 | 2018 |
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0.100 | Biomarker | disease | BEFREE | Decreased microRNA-140-5p contributes to respiratory syncytial virus disease through targeting Toll-like receptor 4. | 30116350 | 2018 |
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0.100 | GeneticVariation | disease | BEFREE | Two independent populations of infants with RSV bronchiolitis revealed that the severity of RSV infection is determined by the TLR4 genotype of the individual and by environmental exposure to LPS. | 25555213 | 2015 |
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0.100 | GeneticVariation | disease | BEFREE | The aim of this study was to investigate the possible role of polymorphisms of TLR4, Asp299Gly and Thr399Ile and CD14, C-159T and C-550T in the development of RSV bronchiolitis. | 25572736 | 2015 |
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0.100 | Biomarker | disease | BEFREE | TLR4 activates the innate immune system on RSV exposure. | 23888080 | 2013 |
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0.100 | AlteredExpression | disease | BEFREE | MDD exhibited significant antiviral and anti-inflammatory effects on decreasing levels of Eotaxin, IL-4 and IFN-γ in serum and lung tissue, inhibiting pneumonia, decreasing lung viral loads and reversaling RSV-induced inflammation through down-regulation of TLR4 and NF-κB mRNA expression in the lung tissue of RSV-infected mice. | 23506991 | 2013 |
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0.100 | AlteredExpression | disease | BEFREE | Toll-like receptor 4 (TLR4), a signaling receptor for structurally diverse microbe-associated molecular patterns, is activated by the RSV fusion (F) protein and by bacterial lipopolysaccharide (LPS) in a CD14-dependent manner. | 22872782 | 2012 |
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0.100 | Biomarker | disease | BEFREE | Thus, although isolated viral compounds such as purified RSV F protein may bind TLR4 and/or CD14, a direct interaction between intact RSV particles and the human TLR4 receptor complex does not seem to play a biological role in RSV pathogenesis. | 22535679 | 2012 |
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0.100 | Biomarker | disease | BEFREE | Surfactant proteins A and D are able to bind both RSV and TLR4, modulating the inflammatory response. | 20963841 | 2011 |
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0.100 | GeneticVariation | disease | BEFREE | The TLR4 (Asp299Gly), TLR4 (Thr399Ile), and JUN (c.750G/A) SNPs showed no significant association with RSV disease. | 21837802 | 2011 |
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0.100 | GeneticVariation | disease | BEFREE | TLR4 Asp299Gly and Thr399Ile polymorphisms: no impact on human immune responsiveness to LPS or respiratory syncytial virus. | 20711470 | 2010 |
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0.100 | GeneticVariation | disease | BEFREE | The aim was to study the association between the TLR4 Asp299Gly polymorphism and the susceptibility to severe RSV bronchiolitis in infants. | 20575099 | 2010 |
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0.100 | Biomarker | disease | BEFREE | TLR4 has already been described in association with RSV associated diseases by us and others. | 18776592 | 2008 |
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0.100 | GeneticVariation | disease | BEFREE | By genotyping 236 children with RSV infection and 219 healthy controls we found no association between the risk of severe RSV infection and Asp299Gly polymorphisms (P>0.05), and we demonstrate that the TLR4 Asp299Gly genotype does not influence susceptibility to either RSV serotype A or B (P>0.05). | 17449325 | 2007 |
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0.100 | Biomarker | disease | BEFREE | Our data suggest that heterozygosity of these two extracellular TLR4 polymorphisms is highly associated with symptomatic RSV disease in high-risk infants and support a dual role for TLR4 SNPs in prematurity and increased susceptibility to RSV not revealed by analysis of either alone. | 17709532 | 2007 |
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0.100 | GeneticVariation | disease | BEFREE | No TLR4 mutations were found.The frequencies of both the CC genotype and the C allele of CD14 -550 C/T were significantly higher in children with RSV bronchiolitis than in the control subjects. | 17471431 | 2007 |
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0.100 | GeneticVariation | disease | BEFREE | We genotyped the CD14 promotor polymorphism -C159T and the two common TLR4 amino acid variants (D259G, and T359I) in 131 infants with severe RSV associated diseases and 270 controls. | 17264400 | 2006 |
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0.100 | GeneticVariation | disease | BEFREE | The presence of TLR4 mutations (Asp299Gly and Thr399Ile) were associated with severe RSV bronchiolitis and were significantly over-represented in groups II and III. | 16542364 | 2006 |
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0.100 | GeneticVariation | disease | BEFREE | Each of the TLR4 mutations, either alone or in cosegregation, were associated with severe RSV bronchiolitis: the Asp299Gly and Thr399Ile mutations were significantly overrepresented in group I, compared with groups II and III. | 15143473 | 2004 |
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0.100 | AlteredExpression | disease | BEFREE | This theory is supported by studies showing that Toll-like receptor 4 is activated by respiratory syncytial virus (RSV), leading to production of inflammatory cytokines. | 15143472 | 2004 |
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0.100 | Biomarker | disease | BEFREE | The first response occurs early after RSV inoculation, is AM and TLR4 dependent, and is viral replication independent, whereas the second response involves epithelial cells and/or inflammatory cells, is TLR4 independent, and requires viral replication. | 12402188 | 2002 |
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0.100 | Biomarker | disease | BEFREE | RSV persisted longer in the lungs of infected TLR4-deficient mice compared to normal mice. | 11062499 | 2000 |