Endotoxemia
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
Activation of the TLR4/TRAF6/NF-κB pathways was involved in the occurrence and development of intestinal mucosal injury and endotoxemia in mice with OJ.
|
31671112 |
2019 |
Endotoxemia
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
Green Tea Extract Treatment in Obese Mice with Nonalcoholic Steatohepatitis Restores the Hepatic Metabolome in Association with Limiting Endotoxemia-TLR4-NFκB-Mediated Inflammation.
|
31574193 |
2019 |
Endotoxemia
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
Likewise, horses are highly susceptible to endotoxemia but the expression and function of TLR4 on horse B lymphocytes is not known.
|
30901382 |
2019 |
Endotoxemia
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
Alkaline phosphatase (AP) is currently being investigated as an anti-inflammatory agent for detoxifying LPS through dephosphorylating lipid A, thus providing a potential treatment for managing both acute (sepsis) and chronic (metabolic endotoxemia) pathologies wherein aberrant TLR4/MD2 activation has been implicated.
|
31704704 |
2019 |
Endotoxemia
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
MicroRNA-141 ameliorates alcoholic hepatitis‑induced intestinal injury and intestinal endotoxemia partially via a TLR4-dependent mechanism.
|
31173169 |
2019 |
Endotoxemia
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
We hypothesize (I) PD-driven endotoxemia may increase the host responsiveness to autoantigens via TLR4 activation and (II) this participates in development and propagation of RA (III) circulating PD-derived bacterial DNA is taken up by phagocytes, activates TLR9, and thus increases the responsiveness to autoantigens.
|
30417696 |
2018 |
Endotoxemia
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
MV with endotoxemia aggravated VIDD, as demonstrated by the increases in the expression levels of TLR4, caspase-3, atrogin-1, muscle ring finger-1, and microtubule-associated protein light chain 3-II.
|
29925937 |
2018 |
Endotoxemia
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
One potential mechanism is via gut microbiota derived bacterial lipopolysaccharide (LPS) entering into the circulation and activation of Toll-like receptor-4.This is called metabolic endotoxemia.
|
30353127 |
2018 |
Endotoxemia
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
Here, we (1) determine whether oral gavage of LPS, as a model of gut-derived endotoxemia, affects anxiety-like and/or repetitive behaviors; (2) test whether these changes depend on TLR4 signaling; and (3) test the extent to which gut-derived endotoxin and TLR4 antagonism affects males and females differently.
|
29351816 |
2018 |
Endotoxemia
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
MSCs can improve chronic colitis-associated hepatobiliary complications, probably by inhibition of enterogenous endotoxemia and hepatic inflammation through LPS/TLR4 pathway.
|
30103680 |
2018 |
Endotoxemia
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
Activation of the TLR4 receptor by bacterial lipopolysaccharide (LPS) is the most widely studied TLR pathway due to its central role in host responses to gram-negative bacterial infection and its contribution to endotoxemia and sepsis.
|
28248925 |
2017 |
Endotoxemia
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
Resultant leaching of gut caused portal endotoxemia that led to upregulation of toll like receptor 4 (TLR4) activation in the small intestine and the brain.
|
28328972 |
2017 |
Endotoxemia
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
This study was undertaken to determine if endotoxaemia potentiates early stasis thrombogenesis, and secondarily to determine the role of VT TLR4, ICAM-1 and neutrophils (PMNs).
|
27975098 |
2017 |
Endotoxemia
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
This activity was demonstrated <i>in vitro</i> using both RAW 264.7 cells and a human Toll-like receptor 4 (TLR4) reporter cell line, as well as in a murine model of endotoxemia using purified LPS for challenge.
|
28874372 |
2017 |
Endotoxemia
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
Activation of the TLR4 receptor by bacterial lipopolysaccharide (LPS) is the most widely studied TLR pathway due to its central role in host responses to gram-negative bacterial infection and its contribution to endotoxemia and sepsis.
|
28248930 |
2017 |
Endotoxemia
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
Highlights of this study include: human SAA is possibly only expressed in a subset of septic patients; SAA induces HMGB1 release via TLR4 and RAGE receptors; SAA supplementation worsens the outcome of lethal endotoxemia; whereas SAA-neutralizing antibodies confer protection against lethal endotoxemia and sepsis.
|
26052716 |
2015 |
Endotoxemia
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
However, a high-fat diet activates TLR-2s, and obesity activates TLR-4s and induces spontaneous increases in serum lipopolysaccharide levels (metabolic endotoxemia).
|
25840582 |
2015 |
Endotoxemia
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
Recent studies have suggested that bacterial overgrowth and endotoxemia along with its receptor, Toll-like receptor 4 (TLR-4), play a role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD).
|
24443993 |
2014 |
Endotoxemia
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
Immune cell Toll-like receptor 4 mediates the development of obesity- and endotoxemia-associated adipose tissue fibrosis.
|
24794440 |
2014 |
Endotoxemia
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
Our lead compound, C34, is a 2-acetamidopyranoside (MW 389) with the formula C17H27NO9, which inhibited TLR4 in enterocytes and macrophages in vitro, and reduced systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis.
|
23776545 |
2013 |
Endotoxemia
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
Bone marrow and nonbone marrow Toll like receptor 4 regulate acute hepatic injury induced by endotoxemia.
|
23977376 |
2013 |
Endotoxemia
|
0.300 |
Therapeutic
|
phenotype |
RGD |
ITF can alleviate intestinal injury in young rats with endotoxemia, which may be related to the down-regulation of TLR4 mRNA expression.
|
22172266 |
2011 |
Endotoxemia
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
Apoptosis signal-regulating kinase 1 (ASK1) is also required for LPS-induced activation of p38, which is a crucial determinant for the production of pro-inflammatory cytokines via Toll-like receptor 4 (TLR4) in endotoxemia.
|
21515258 |
2011 |
Endotoxemia
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
Here, we provide the first evidence that Toll-like receptor 4 (TLR4) is induced by hepatocyte-specific transgenic (Tg) expression of the HCV nonstructural protein NS5A, and this induction mediates synergistic liver damage and tumor formation by alcohol-induced endotoxemia.
|
19171902 |
2009 |
Endotoxemia
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
LPS analogues that act as antagonists at Toll-like receptor 4 (TLR4) are being developed as novel treatments for endotoxaemia.
|
17320193 |
2007 |