|
Ischemic stroke
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Finally, we showed that Vsig4 could interact with TLR4 and repress its expression, subsequently alleviating ischemic stroke.
|
31784084 |
2020 |
|
Ischemic stroke
|
0.100 |
Biomarker
|
disease |
BEFREE |
Results- Our results demonstrate that (1) administration of DNase-I, which promotes NETs lysis, but not of tPA, recanalizes the occluded vessel improving photothrombotic stroke outcome; (2) a preventive treatment with Cl-amidine, impeding NET formation, completely precludes thrombotic occlusion; (3) platelet TLR4 mediates NET formation after photothrombotic stroke; and (4) ex vivo fresh platelet-rich thrombi from ischemic stroke patients are effectively lysed by DNase-I.
|
31526124 |
2019 |
|
Ischemic stroke
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cerebral ischemia was produced by occlusion of the middle cerebral artery, followed by reperfusion for 24 h. We demonstrated that knockout of TLR4 improves ischemic stroke brain associated with eicosanoid down-regulation.
|
30794438 |
2019 |
|
Ischemic stroke
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Ischemic stroke increased the expression of TLR-4 in both hemispheres and in the microvasculature of diabetic animals.
|
29909454 |
2019 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this review, the gene and protein structures, common genetic polymorphisms of TLR2 and TLR4, TLR-related molecular pathways and their putative role after ischemic stroke are delineated.
|
30377701 |
2019 |
|
Ischemic stroke
|
0.100 |
Biomarker
|
disease |
BEFREE |
Microglial GPR30 exerts acute neuroprotective effects by inhibiting TLR4-mediated microglial inflammation, which indicates that GPR30 may be a potential target for the treatment of ischemic stroke.
|
30001721 |
2018 |
|
Ischemic stroke
|
0.100 |
Biomarker
|
disease |
BEFREE |
The aim of our study was to determine the association between selected cytokine release after TLR4 activation in blood cells and the outcome after ischemic stroke.
|
29275013 |
2018 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The TLR4 gene rs1927914 polymorphism was associated with susceptibility to IS in males.
|
29075930 |
2018 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The results revealed a lack of association for TLR4 variant with ischemic stroke and hemorrhagic stroke, although a significant association was observed with the subtypes extracranial large artery (p = 0.008), other determined aetiology (p = 0.03) and undetermined aetiology (p = 0.01).
|
28963650 |
2017 |
|
Ischemic stroke
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
TLR4 is constitutively expressed on monocytes and endothelial cells; it is highly expressed in atherosclerotic plaques and in peripheral blood of patients after ischemic stroke.
|
24108365 |
2013 |
|
Ischemic stroke
|
0.100 |
Biomarker
|
disease |
BEFREE |
The purpose of this study is to elucidate the TLR4 downstream pathways following ischemic stroke.
|
23726813 |
2013 |
|
Ischemic stroke
|
0.100 |
Biomarker
|
disease |
BEFREE |
We investigated independent and joint associations of variations in cholesterol ester transfer protein (CETP), interleukin-8 (IL8), peroxisome proliferator activator receptor-alpha (PPARA), and Toll-like receptor 4 (TLR4) genes with incident nonfatal myocardial infarction (MI) or ischemic stroke.
|
18549840 |
2008 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Toll-like receptor 4 gene C119A but not Asp299Gly polymorphism is associated with ischemic stroke among ethnic Chinese in Taiwan.
|
15910856 |
2005 |