TLR4, toll like receptor 4, 7099

N. diseases: 1174; N. variants: 54
Disease: Acute colitis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2118460
Disease: Acute colitis
Acute colitis 		0.030 Biomarker disease BEFREE Interestingly, WT mice cohoused with villin-TLR4 mice displayed greater susceptibility to acute colitis than singly housed WT mice did. 26755160 2016
CUI: C2118460
Disease: Acute colitis
Acute colitis 		0.030 AlteredExpression disease BEFREE In vivo, mucosal EPI and AR expression are significantly decreased in TLR4(-/-) mice (P=0.02) compared to wild-type mice during acute colitis. 20498653 2010
CUI: C2118460
Disease: Acute colitis
Acute colitis 		0.030 Biomarker disease BEFREE As compared to wt animals, TLR2(-/-), TLR4(-/-), and TLR2/4(-/-) mice displayed reduced macroscopic signs of acute colitis and the amelioration of inflammation was associated with reduced IFN-gamma levels in mesenteric lymph nodes, lower amounts of neutrophils, and less FOXP3-positive T-cells in the colon in situ. 17653282 2007