TLR5, toll like receptor 5, 7100

N. diseases: 163; N. variants: 6
Disease: Pneumonia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0032285
Disease: Pneumonia
Pneumonia 		0.020 Biomarker disease BEFREE Ligation of TLR5, a pathogen recognition receptor not naturally engaged by pneumococcus, protects mice from invasive pneumonia when administered via sublingual route. 27546231 2016
CUI: C0032285
Disease: Pneumonia
Pneumonia 		0.020 GeneticVariation disease BEFREE Here, we show that a common stop codon polymorphism in the ligand-binding domain of TLR5 (TLR5392STOP) is unable to mediate flagellin signaling, acts in a dominant fashion, and is associated with susceptibility to pneumonia caused by Legionella pneumophila, a flagellated bacterium. 14623910 2003