Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Ang-1 has been shown to promote the development of atherosclerosis, whereas little is known about its effects on lipid metabolism and inflammation in this process.
|
31678621 |
2020 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Infusion of Ang-(1-7), a Mas receptor (MasR) ligand, to hypercholesterolemic male mice reduced AngII-induced atherosclerosis, suggesting a protective role of the Ang-(1-7)/MasR axis.
|
30850299 |
2019 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
To test whether Ang-(1-7) modulates atherosclerosis through a NO-dependent mechanism, apoE-KO mice were treated with the NO synthase inhibitor L-NAME (20 mg/kg/day) in the presence or absence of Ang-(1-7).
|
29352340 |
2018 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
While the beneficial effects of Ang-(1-7) have been widely studied in several experimental models of hypertension, much less studies were performed in experimental models of atherosclerosis.
|
29541937 |
2018 |
Arteriosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Application of NaHS, an H<sub>2</sub>S donor considerably attenuated the severity of atherosclerosis with upregulating carotid expression of ACE2, thus converting pro-atherosclerotic angiotensin II (Ang II) to anti-atherosclerotic angiotensin 1-7 (Ang-(1-7)).
|
29066981 |
2017 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Ang-1 specifically increases circulating Gr1<sup>+ </sup>inflammatory monocytes and increases monocyte/macrophage retention in atherosclerotic plaques, thereby contributing to development of atherosclerosis.
|
28069704 |
2017 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results suggest that Ang-(1-7) plays an important role in protecting against atherosclerosis via counter-regulation of Ang II-induced MMP-8.
|
28283184 |
2017 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The attenuation of Ang-(1-7) and losartan in atherosclerosis plaque formation was similar.
|
25957120 |
2015 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Ang (1-7) may, therefore, have therapeutic benefits for the treatment of atherosclerosis.
|
25779847 |
2015 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
ACE2 and Ang-(1-7) protect endothelial cell function and prevent early atherosclerosis by inhibiting inflammatory response.
|
25721616 |
2015 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results demonstrate that ACE2 deficiency in bone marrow-derived cells promotes atherosclerosis through regulation of Ang II/Ang-(1-7) peptides.
|
21252069 |
2011 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we studied the roles of Ang1, its natural antagonist Ang2, and their receptor Tie2 in rat cardiac allograft arteriosclerosis.
|
12628953 |
2003 |