TMPRSS2, transmembrane serine protease 2, 7113

N. diseases: 69; N. variants: 3
Disease: Hemorrhagic Fever, Ebola ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0282687
Disease: Hemorrhagic Fever, Ebola
Hemorrhagic Fever, Ebola 		0.010 Biomarker disease BEFREE Here, we show that cathepsin B/L inhibitors markedly reduce 293T cell infection driven by the GPs of all EBOV species, independent of the type II transmembrane serine protease TMPRSS2, which cleaved but failed to activate EBOV-GPs. 22222211 2012