TMPRSS2, transmembrane serine protease 2, 7113

N. diseases: 69; N. variants: 3
Disease: Influenza A ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2062441
Disease: Influenza A
Influenza A 		0.040 Biomarker disease BEFREE This study identifies TMPRSS2 as the major HA-activating protease of IAV in human airway cells and IBV in type II pneumocytes and as a potential target for the development of novel drugs to treat influenza infections.<b>IMPORTANCE</b> Influenza A viruses (IAV) and influenza B viruses (IBV) cause significant morbidity and mortality during seasonal outbreaks. 31391268 2019
CUI: C2062441
Disease: Influenza A
Influenza A 		0.040 Biomarker disease BEFREE Here, we investigated the sequence requirements for the HA molecule that allow IAV to replicate efficiently in the absence of TMPRSS2. 30084768 2018
CUI: C2062441
Disease: Influenza A
Influenza A 		0.040 Biomarker disease BEFREE The cellular serine protease TMPRSS2, a member of the type II transmembrane serine protease (TTSP) family, cleaves and activates the hemagglutinin of influenza A viruses (FLUAV) in cell culture and is essential for spread of diverse FLUAV in mice. 28493964 2017
CUI: C2062441
Disease: Influenza A
Influenza A 		0.040 Biomarker disease BEFREE As expected, Tmprss2-deficient mice were not protected from viral spread and pathology after infection with multi-basic H7N7 influenza A virus. 24348248 2013