TMPRSS2, transmembrane serine protease 2, 7113

N. diseases: 69; N. variants: 3
Disease: Middle East Respiratory Syndrome ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C3694279
Disease: Middle East Respiratory Syndrome
Middle East Respiratory Syndrome 		0.020 Biomarker disease BEFREE Transmembrane serine protease TMPRSS2 activates the spike protein of highly pathogenic human coronaviruses such as severe acute respiratory syndrome-related coronavirus (SARS-CoV) and Middle East respiratory syndrome-related coronavirus (MERS-CoV). 30626688 2019
CUI: C3694279
Disease: Middle East Respiratory Syndrome
Middle East Respiratory Syndrome 		0.020 Biomarker disease BEFREE Therefore, therapeutic agents for coronavirus-mediated diseases, such as severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), should target cell surface TMPRSS2 rather than endosomal cathepsin. 27733646 2017