|
cervical cancer
|
0.100 |
Biomarker
|
disease |
BEFREE |
TNF-α-induced apoptosis has been confirmed, however, relatively little is known regarding the role of forkhead box class-O 1 (FOXO1) in mediating TNF-α-induced apoptosis in cervical cancer.
|
26214423 |
2015 |
|
cervical cancer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A comprehensive search was conducted to examine all the eligible studies of TNF-α -308 G>A polymorphism and cervical cancer risk.
|
22146770 |
2012 |
|
cervical cancer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
All the case-control studies published from January 1989 to October 2010 on the association between the two polymorphisms of TNFA and cervical cancer risk were identified by searching the electronic literature Medline.
|
21670964 |
2012 |
|
cervical cancer
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) provides tumor-specific apoptosis in various cancers, including cervical cancer, the sensitivity differs depending on the cell lines.
|
27599897 |
2016 |
|
cervical cancer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Although our findings support the general hypothesis that host immunogenetic determinants other than class II MHC may be important in the development of cervical cancer, further analysis of the HLA gene cluster comprising the implicated TNFalpha single-nucleotide polymorphisms will be required to determine whether their association is linkage independent.
|
12142377 |
2002 |
|
cervical cancer
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cox multivariate analysis disclosed that carbohydrate antigen 153 (CA153), squamous cell carcinoma antigen (SCC) and tumor necrosis factor-α (TNF-α) are associated with prognosis in cervical cancer.
|
23850705 |
2013 |
|
cervical cancer
|
0.100 |
Biomarker
|
disease |
BEFREE |
Fucoxanthin and Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) Synergistically Promotes Apoptosis of Human Cervical Cancer Cells by Targeting PI3K/Akt/NF-κB Signaling Pathway.
|
29291370 |
2018 |
|
cervical cancer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
However, we found a significant trend for the p value, as well as the contribution of TNF-α -308 G/A to cervical cancer, in stages III and IV.
|
25614219 |
2015 |
|
cervical cancer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, individuals with TNFA -308*A allele carriers were at significantly higher risk of cervical cancer particularly early (IB) and advanced stages (III).
|
19823053 |
2009 |
|
cervical cancer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, these results suggest a potential effect of TNF-α -238 G/A in the reduction of cervical cancer risk in Argentine women, but not TNF-α -308 or IL-10.
|
22592655 |
2012 |
|
cervical cancer
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the present study, we investigated the role of Cx32 in extrinsic apoptosis induced by treatment with TNFα + cycloheximide (CHX) or afatinib in human cervical cancer (CaCx) cells.
|
28901517 |
2017 |
|
cervical cancer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
It suggests that SNP at -308 (G/A) of TNFalpha promoter may represent an increased risk for HPV infection and development of cervical cancer in Indian women.
|
17452777 |
2007 |
|
cervical cancer
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our findings indicate that the association of TNFA with cervical cancer is different with CIN.
|
11600224 |
2001 |
|
cervical cancer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our meta-analysis indicates that TNF-α polymorphisms may confer susceptibility to cervical cancer in an ethic-specific fashion.
|
25069725 |
2015 |
|
cervical cancer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our study suggests that the presence of the high producer allele TNFα-307A is associated with an increased risk for the development of cervical cancer in the Posadas population.
|
22019249 |
2012 |
|
cervical cancer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Published data linking single nucleotide polymorphisms (SNPs) in the tumor necrosis factor-alpha (TNF-?) promoter region at positions -308G>A (rs1800629) and -238G>A (rs361525) to cervical cancer risk have been inconclusive.
|
27039819 |
2016 |
|
cervical cancer
|
0.100 |
Biomarker
|
disease |
BEFREE |
Re-expression of HPV16 E2 in SiHa (human cervical cancer) cells potentiates NF-κB activation induced by TNF-α concurrently increasing senescence and survival.
|
25572145 |
2015 |
|
cervical cancer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Taken together, these results suggest that TNF-308 AA and IL10-592 CA/AA genotypes may increase susceptibility to cervical cancer by altering the immune response of an individual.
|
30453149 |
2019 |
|
cervical cancer
|
0.100 |
Biomarker
|
disease |
BEFREE |
The TNF region was significantly associated with the risks of cervical cancer (gene-based p-value: 2.0 × 10(-4) ) and vulvar cancer (gene-based p-value: 1.0 × 10(-4) ).
|
23824834 |
2014 |
|
cervical cancer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to assess the association of TNF-α/rs1799724 and CXCL12/rs266085 polymorphisms with susceptibility to cervical cancer in Han Chinese population in Shandong Province.
|
26191295 |
2015 |
|
cervical cancer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to explore the association of a variant, TNF-308 G>A, residing in the TNFa gene with cervical cancer.
|
30387170 |
2019 |
|
cervical cancer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The Correlation Between TNF-α Promoter Gene Polymorphism and Genetic Susceptibility to Cervical Cancer.
|
29940817 |
2018 |
|
cervical cancer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The meta-analysis suggests that TNF-α 308 G/A polymorphism is associated with increased risk of cervical cancer, and TNF-α 308 G/A mutant allele A is a risk factor of cervical cancer.
|
23494178 |
2013 |
|
cervical cancer
|
0.100 |
Biomarker
|
disease |
BEFREE |
There might be an association of the TLR2 and TLR4 pathways with the immunological response of TNF-α and TNF-β in cervical cancer.
|
28009429 |
2017 |
|
cervical cancer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Therefore the aim of the study was to investigate the allelic distribution of -308 TNF-alpha gene polymorphism in South African women with cervical cancer compared to control women.
|
16438713 |
2006 |