TNF, tumor necrosis factor, 7124
N. diseases: 2724; N. variants: 31
Source: ALL
| Disease | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year |
|---|---|---|---|---|---|---|---|
|
|
0.100 | Biomarker | disease | BEFREE | Increased gastric production of interleukin 8 and tumor necrosis factor alpha (TNF-alpha) has been implicated in the pathogenesis of Helicobacter pylori-associated gastroduodenal disease. | 12011009 | 2002 |
|
|
0.100 | Biomarker | disease | BEFREE | The carcinogenic features of TNF-α are described in this review, and the TNF-α inducing protein (Tipα) of Helicobacter pylori genome is presented as an example of a tumor promoter of human stomach cancer development. | 21269254 | 2011 |
|
|
0.100 | Biomarker | disease | BEFREE | Cell-surface nucleolin in human gastric cancer cell lines is a receptor for TNF-α-inducing protein (Tipα) of Helicobacter pylori. | 24469254 | 2014 |
|
|
0.100 | Biomarker | disease | BEFREE | Epithelial-mesenchymal transition in human gastric cancer cell lines induced by TNF-α-inducing protein of Helicobacter pylori. | 24249671 | 2014 |
|
|
0.100 | Biomarker | disease | BEFREE | Moreover, the activating effect of TNF-α was markedly augmented by the infection of Helicobacter pylori, the primary cause of human gastritis. | 25008775 | 2014 |
|
|
0.100 | AlteredExpression | disease | BEFREE | Induction of TLR-2 and TLR-5 expression by Helicobacter pylori switches cagPAI-dependent signalling leading to the secretion of IL-8 and TNF-α. | 21573018 | 2011 |
|
|
0.100 | GeneticVariation | disease | BEFREE | Subjects with TNF-A-857TT and -1031TT genotypes showed the highest Helicobacter pylori seropositive rate compared with those with other genotypes. | 14716517 | 2003 |
|
|
0.100 | Biomarker | disease | BEFREE | Tumor necrosis factor (TNF)-α-inducing protein (Tipα) is a newly identified carcinogenic factor secreted by Helicobacter pylori (H. pylori). | 28130110 | 2017 |
|
|
0.100 | Biomarker | disease | BEFREE | Recent investigations have indicated that produced inflammatory cytokines such as TNF-α and IL-1β in response to gastric infection by Helicobacter pylori play an important role in the development of peptic ulcer. | 29456060 | 2018 |
|
|
0.100 | Biomarker | disease | BEFREE | Fecal Helicobacter pylori glmM and 16S rRNA genes correlate with serum TNF-α and IL-1β cytokine fluctuations. | 30024269 | 2018 |
|
|
0.100 | GeneticVariation | disease | BEFREE | The effects of genetic polymorphisms of IL-1 and TNF-A on Helicobacter pylori-induced gastroduodenal diseases in Korea. | 16579840 | 2006 |
|
|
0.100 | AlteredExpression | disease | BEFREE | Involvement of tumor necrosis factor-alpha in the upregulation of CXCR4 expression in gastric cancer induced by Helicobacter pylori. | 20699000 | 2010 |
|
|
0.100 | GeneticVariation | disease | BEFREE | Association between TNF-alpha promoter polymorphism and Helicobacter pylori cagA subtype infection. | 11533078 | 2001 |
|
|
0.100 | Biomarker | disease | BEFREE | In mice model, HDGF ablation significantly suppressed the Hp-induced neutrophil infiltration and inflammatory TNF-α/COX-2 signaling, thereby relieving the tissue damage in stomach. | 31332288 | 2019 |
|
|
0.100 | AlteredExpression | disease | BEFREE | Molecular and histological evaluation of tumor necrosis factor-alpha expression in Helicobacter pylori-mediated gastric carcinogenesis. | 20512382 | 2011 |
|
|
0.100 | GeneticVariation | disease | BEFREE | The aim of our study was to investigate the impact of interleukin (IL)-6 190C/T, IL-6 174G/C, IL-6 572G/C, tumor necrosis factor-alpha (TNF-α) 308G/A, and angiotensin-converting enzyme (ACE) I/D gene polymorphisms on Helicobacter pylori (H. pylori) infection in children.A cross-sectional study was performed on 126 children (57 children with H. pylori infection and 69 children without H. pylori infection) aged between 3 and 18 years presenting to a Pediatrics Tertiary Hospital from Romania. | 28746216 | 2017 |
|
|
0.100 | AlteredExpression | disease | BEFREE | Activation of TNF-α/NF-κB-related signaling pathway is crucial in sustain the growth of Helicobacter pylori-independent gastric mucosa-associated lymphoid tissue type (MALT) lymphoma. | 21465313 | 2011 |
|
|
0.100 | AlteredExpression | disease | BEFREE | To investigate the expression level of tumor necrosis factor receptor-associated factor 1 (TRAF1) in gastric mucosa tissue in patients infected with Helicobacter pylori (H. pylori) and to analyze the relationship between TRAF1 expression and H. pylori virulence. | 24852885 | 2014 |
|
|
0.100 | GeneticVariation | disease | BEFREE | Relationship of IL-1 and TNF-α polymorphisms with Helicobacter pylori in gastric diseases in a Brazilian population. | 22714811 | 2012 |
|
|
0.100 | Biomarker | disease | BEFREE | Human gastric cancer development with TNF-α-inducing protein secreted from Helicobacter pylori. | 22459353 | 2012 |
|
|
0.100 | GeneticVariation | disease | BEFREE | Combination of Helicobacter pylori strain and tumor necrosis factor-alpha polymorphism of the host increases the risk of peptic ulcer disease in children. | 17667716 | 2007 |
|
|
0.100 | AlteredExpression | disease | BEFREE | Circulating levels of soluble tumor necrosis factor receptor-75 were reduced only in the HP+/AZ group after 3 months of AZ treatment (-0.87 ± 0.31 μg/L; p = 0.002); levels returned to baseline after discontinuing AZ. | 28558695 | 2017 |
|
|
0.100 | Biomarker | disease | BEFREE | In conclusion, the results of the present study indicated that Helicobacter pylori CagA enhanced TNF‑α and IL‑6 in gastric adenocarcinoma cells through PCAF‑mediated NF‑κB p65 sub‑unit acetylation. | 26238217 | 2015 |
|
|
0.100 | Biomarker | disease | BEFREE | These data suggest that TNF-alpha and IL-1 may play a direct role in Helicobacter pylori-induced hypergastrinemia. | 11705745 | 2001 |
|
|
0.100 | Biomarker | disease | BEFREE | The aim of this study was to evaluate whether there was any correlation between Helicobacter pylori-associated diseases and (1) H. pylori virulence genes or (2) IL-1B, IL-1RN, IFN-G, TNF-A, IL-10 genetic polymorphisms. | 15652446 | 2005 |