TNF, tumor necrosis factor, 7124
N. diseases: 2724; N. variants: 31
Source: ALL
| Disease | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year |
|---|---|---|---|---|---|---|---|
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0.100 | Biomarker | disease | BEFREE | In mice model, HDGF ablation significantly suppressed the Hp-induced neutrophil infiltration and inflammatory TNF-α/COX-2 signaling, thereby relieving the tissue damage in stomach. | 31332288 | 2019 |
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0.100 | AlteredExpression | disease | BEFREE | Helicobacter pylori-downregulated tumor necrosis factor receptor-associated protein 1 mediates apoptosis of human gastric epithelial cells. | 30710368 | 2019 |
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0.100 | Biomarker | disease | BEFREE | Recent investigations have indicated that produced inflammatory cytokines such as TNF-α and IL-1β in response to gastric infection by Helicobacter pylori play an important role in the development of peptic ulcer. | 29456060 | 2018 |
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0.100 | Biomarker | disease | BEFREE | Fecal Helicobacter pylori glmM and 16S rRNA genes correlate with serum TNF-α and IL-1β cytokine fluctuations. | 30024269 | 2018 |
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0.100 | Biomarker | disease | BEFREE | Tumor necrosis factor (TNF)-α-inducing protein (Tipα) is a newly identified carcinogenic factor secreted by Helicobacter pylori (H. pylori). | 28130110 | 2017 |
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0.100 | GeneticVariation | disease | BEFREE | The aim of our study was to investigate the impact of interleukin (IL)-6 190C/T, IL-6 174G/C, IL-6 572G/C, tumor necrosis factor-alpha (TNF-α) 308G/A, and angiotensin-converting enzyme (ACE) I/D gene polymorphisms on Helicobacter pylori (H. pylori) infection in children.A cross-sectional study was performed on 126 children (57 children with H. pylori infection and 69 children without H. pylori infection) aged between 3 and 18 years presenting to a Pediatrics Tertiary Hospital from Romania. | 28746216 | 2017 |
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0.100 | AlteredExpression | disease | BEFREE | Circulating levels of soluble tumor necrosis factor receptor-75 were reduced only in the HP+/AZ group after 3 months of AZ treatment (-0.87 ± 0.31 μg/L; p = 0.002); levels returned to baseline after discontinuing AZ. | 28558695 | 2017 |
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0.100 | Biomarker | disease | BEFREE | Modulation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis by Helicobacter pylori in immune pathogenesis of gastric mucosal damage. | 26947589 | 2017 |
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0.100 | Biomarker | disease | BEFREE | In conclusion, the results of the present study indicated that Helicobacter pylori CagA enhanced TNF‑α and IL‑6 in gastric adenocarcinoma cells through PCAF‑mediated NF‑κB p65 sub‑unit acetylation. | 26238217 | 2015 |
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0.100 | GeneticVariation | disease | BEFREE | Normal gastric epithelial cells (GES-1) were treated with Helicobacter pylori (H. pylori) and tumor necrosis factor (TNF)-α. | 26316259 | 2015 |
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0.100 | Biomarker | disease | BEFREE | Cell-surface nucleolin in human gastric cancer cell lines is a receptor for TNF-α-inducing protein (Tipα) of Helicobacter pylori. | 24469254 | 2014 |
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0.100 | Biomarker | disease | BEFREE | Epithelial-mesenchymal transition in human gastric cancer cell lines induced by TNF-α-inducing protein of Helicobacter pylori. | 24249671 | 2014 |
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0.100 | Biomarker | disease | BEFREE | Moreover, the activating effect of TNF-α was markedly augmented by the infection of Helicobacter pylori, the primary cause of human gastritis. | 25008775 | 2014 |
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0.100 | AlteredExpression | disease | BEFREE | To investigate the expression level of tumor necrosis factor receptor-associated factor 1 (TRAF1) in gastric mucosa tissue in patients infected with Helicobacter pylori (H. pylori) and to analyze the relationship between TRAF1 expression and H. pylori virulence. | 24852885 | 2014 |
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0.100 | AlteredExpression | disease | BEFREE | Integrin-linked kinase modulates lipopolysaccharide- and Helicobacter pylori-induced nuclear factor κB-activated tumor necrosis factor-α production via regulation of p65 serine 536 phosphorylation. | 25100717 | 2014 |
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0.100 | GeneticVariation | disease | BEFREE | Relationship of IL-1 and TNF-α polymorphisms with Helicobacter pylori in gastric diseases in a Brazilian population. | 22714811 | 2012 |
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0.100 | Biomarker | disease | BEFREE | Human gastric cancer development with TNF-α-inducing protein secreted from Helicobacter pylori. | 22459353 | 2012 |
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0.100 | AlteredExpression | disease | BEFREE | Using endoscopic biopsies, gastric mucosal expression levels of interleukin (IL)-1β, IL-6, IL-8, and tumor necrosis factor-alpha (TNF-α) messenger RNA (mRNA) and microRNAs (miRNAs) that were differentially expressed in association with Helicobacter pylori were assessed by quantitative reverse-transcriptase polymerase chain reaction. | 22161133 | 2012 |
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0.100 | Biomarker | disease | BEFREE | The carcinogenic features of TNF-α are described in this review, and the TNF-α inducing protein (Tipα) of Helicobacter pylori genome is presented as an example of a tumor promoter of human stomach cancer development. | 21269254 | 2011 |
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0.100 | AlteredExpression | disease | BEFREE | Induction of TLR-2 and TLR-5 expression by Helicobacter pylori switches cagPAI-dependent signalling leading to the secretion of IL-8 and TNF-α. | 21573018 | 2011 |
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0.100 | AlteredExpression | disease | BEFREE | Molecular and histological evaluation of tumor necrosis factor-alpha expression in Helicobacter pylori-mediated gastric carcinogenesis. | 20512382 | 2011 |
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0.100 | AlteredExpression | disease | BEFREE | Activation of TNF-α/NF-κB-related signaling pathway is crucial in sustain the growth of Helicobacter pylori-independent gastric mucosa-associated lymphoid tissue type (MALT) lymphoma. | 21465313 | 2011 |
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0.100 | GeneticVariation | disease | BEFREE | Residence during childhood, socioeconomic status, and smoking habits were investigated as environmental factors, Helicobacter pylori (H. pylori) virulence factors (cagA, vagA s1 and m1 regions, and oipA) were evaluated, and seven biallelic polymorphisms (IL-1B-511, TNF-A-308, IL-6-572, IL-8-251, IL-10-592, IL-10-1082, and TGFB1-509) and IL-1RN variable number of tandem repeats were genotyped. | 21502924 | 2011 |
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0.100 | AlteredExpression | disease | BEFREE | Involvement of tumor necrosis factor-alpha in the upregulation of CXCR4 expression in gastric cancer induced by Helicobacter pylori. | 20699000 | 2010 |
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0.100 | Biomarker | disease | BEFREE | In the early stage, initial response to self-antigens (LF, CA-II, CA-IV, PSTI, or α-fodrin) or molecular mimicry (Helicobacter pylori) is induced by decreased naive regulatory T cells (Tregs), and Th1 cells release proinflammatory cytokines (IFN-γ, IL-1b, IL-2, and TNF-α). | 20862490 | 2010 |