|
Hepatitis
|
0.100 |
Biomarker
|
group |
BEFREE |
Conclusion: Our study uncovers key roles for TNF and, to a lesser extent, IL-17 as mediators of liver inflammation and fibrosis induced by constitutive NLRP3 inflammasome activation in myeloid-derived cells.
|
28902427 |
2018 |
|
Hepatitis
|
0.100 |
Biomarker
|
group |
BEFREE |
When human colon cancer cells were xenografted into these mice, prophylactic blockade of human TNF improved colitis and hepatitis in xenografted mice, and moreover, immunotherapeutic control of xenografted tumours was retained.
|
31043740 |
2019 |
|
Hepatitis
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The Ldlr<sup>-/-</sup> mice fed the high-fat/high-cholesterol diet showed liver inflammation, as reflected by increased (3- to 4-fold) infiltration of inflammatory cells and increased (3- to 4-fold) gene expression of tumor necrosis factor α, integrin αM, intracellular adhesion molecule, and vascular cell adhesion molecule.
|
28990215 |
2018 |
|
Hepatitis
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Serum levels of interleukin 8, chemokine (C-C motif) ligand 3, and tumor necrosis factor-α correlated with liver inflammation and NAFLD activity score.
|
26028579 |
2015 |
|
Hepatitis
|
0.100 |
Biomarker
|
group |
BEFREE |
As TLR4 and SPK/S1P signaling pathways play important roles in the progression of liver inflammation, the effect on sphingosine pathway and TLR4 was associated with decreased concentrations of inflammatory markers, enzyme kB kinase (IKK), nuclear factor-kB and tumor necrosis factor-α as compared to untreated NAFL group.
|
31004566 |
2019 |
|
Hepatitis
|
0.100 |
Biomarker
|
group |
BEFREE |
Interestingly, while TRAIL administration did not induce hepatitis in Ripk1 <sup>LPC-KO</sup> mice or in their WT counterparts, its combination with IFN-γ only induced TNF-α dependent apoptosis in the Ripk1 <sup>LPC-KO</sup> mice.
|
28835677 |
2017 |
|
Hepatitis
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Liver inflammation was confirmed by increase in the levels of TNF-α and IL-6 in carcinogen treated rats.
|
30324893 |
2019 |
|
Hepatitis
|
0.100 |
Biomarker
|
group |
BEFREE |
The production of TNF and FasL indicated that they are the pivotal effectors in this hepatitis.
|
27708340 |
2016 |
|
Hepatitis
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In conclusion, PCT2 is able to constantly reduce and sustain TNF-alpha levels, which is responsible for the sustained decline in liver inflammation as shown by the histological activity index and it is also able to reduce fibrosis as judged both by TGF-beta levels and fibrosis scores.
|
11886178 |
2002 |
|
Hepatitis
|
0.100 |
Biomarker
|
group |
BEFREE |
Overexpression of tumor necrosis factor α (TNFα) is a hallmark of many inflammatory diseases, including rheumatoid arthritis, inflammatory bowel disease, and septic shock and hepatitis, making it a potential therapeutic target for clinical interventions.
|
24634219 |
2014 |
|
Hepatitis
|
0.100 |
Biomarker
|
group |
BEFREE |
TNF-α deficiency attenuated hepatitis in HFHCD-fed mice.
|
26608915 |
2016 |
|
Hepatitis
|
0.100 |
Biomarker
|
group |
BEFREE |
As chronic liver inflammation leads to liver fibrosis, IL-17 and/or TNF-α neutralization can be of interest to control liver inflammation and therefore its effects on fibrosis.
|
31102558 |
2019 |
|
Hepatitis
|
0.100 |
Biomarker
|
group |
BEFREE |
In conclusion, our work demonstrates that therapeutic intervention in the TNF-NF-κB-caspase-8 network is technically feasible and could be of potential benefit in inflammatory liver disease.
|
22153863 |
2012 |
|
Hepatitis
|
0.100 |
Biomarker
|
group |
BEFREE |
Mouse MSCs (mMSCs) significantly reduced Con A- and α-GalCer-mediated hepatitis in C57Bl/6 mice, as demonstrated by histopathological and biochemical analysis, attenuated the influx of inflammatory [T-bet<sup>+</sup> , tumour necrosis factor-α (TNF-α), interferon-γ (IFN-γ)-producing and GATA3<sup>+</sup> , interleukin-4 (IL-4)-producing] liver NKT cells and downregulated TNF-α, IFN-γ and IL-4 levels in the sera.
|
28488390 |
2018 |
|
Hepatitis
|
0.100 |
Biomarker
|
group |
BEFREE |
Eukaryotic elongation factor 2 controls TNF-α translation in LPS-induced hepatitis.
|
23202732 |
2013 |
|
Hepatitis
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Furthermore, global T-cells from the ENEG phase displayed a proinflammatory cytokine profile with upregulated IFN-γ and TNF-α expression, while this profile was suppressed in IT and IA patients.
|
31086463 |
2019 |
|
Hepatitis
|
0.100 |
Biomarker
|
group |
BEFREE |
Inhibition of matrix metalloproteinases blocks lethal hepatitis and apoptosis induced by tumor necrosis factor and allows safe antitumor therapy.
|
11689884 |
2001 |
|
Hepatitis
|
0.100 |
Biomarker
|
group |
BEFREE |
Among 783 patients treated with anti-TNF (n = 472) or DMARDs only (n = 311), HBsAg-/HBcAb+ anti-TNF users had incidence of ALT elevation commensurate with uninfected counterparts (6.1 vs. 6.0/100 person-years), compared to 19.6/100 person-years in HBsAg+ patients (standardized rate ratio 3.3, 95% CI 1.3-8.2); none effected had severe or fatal hepatitis and ALT levels in all HBsAg-/HBcAb+ patients remained stable, mostly normalizing spontaneously, or after moderating treatment.
|
29694398 |
2018 |
|
Hepatitis
|
0.100 |
Biomarker
|
group |
BEFREE |
Genetic ablation of TNF receptor type I (TNFR) in Tak1ΔHep mice remarkably reduced liver inflammation-fibrosis-cancer axis.
|
28875549 |
2018 |
|
Hepatitis
|
0.100 |
Biomarker
|
group |
BEFREE |
Further, we found that chemically inhibiting or activating AhR reciprocally modulated expression levels of cytokines induced by infection, specifically IL-1β, IL-10, and TNFα, consistent with a role for AhR activation in the host response to MHV infection.
|
31694960 |
2020 |
|
Hepatitis
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The E. chaffeensis strain Wakulla induces diffuse hepatitis with neutrophil infiltration in mice with severe combined immunodeficiency, which is accompanied by strong CXCL2 (mouse functional homolog of interleukin-8 [IL-8]) and tumor necrosis factor alpha (TNF-α) expression in the liver.
|
21930764 |
2011 |
|
Hepatitis
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The stepwise logistic regression analysis showed that the TNFα genotypes (GA + AA) were significantly associated with liver inflammation (OR = 3.776, 95%CI: 1.399-10.194, P = 0.009), severe steatosis (OR = 4.49, 95%CI: 1.441-14.0, P = 0.010) and fibrosis progression (OR = 2.84, 95%CI: 1.080-7.472, P = 0.034).
|
27678360 |
2016 |
|
Hepatitis
|
0.100 |
Biomarker
|
group |
BEFREE |
Galectin-3 Deficiency Facilitates TNF-α-Dependent Hepatocyte Death and Liver Inflammation in MCMV Infection.
|
30800112 |
2019 |
|
Hepatitis
|
0.100 |
Biomarker
|
group |
BEFREE |
Our results provide direct evidence that poly(I:C) induces TNF-alpha in d-GalN sensitized mice, which leads to severe, acute, and TNF-dependent lethal hepatitis.
|
18331798 |
2008 |
|
Hepatitis
|
0.100 |
Biomarker
|
group |
BEFREE |
Hence, Fn restrains HFD-induced hepatic inflammation and lipid deposition by downregulating metabolic disorder and excessive liver inflammation-associated TNF-α/RIPK3 axis activation.
|
30793717 |
2019 |