|
Behcet Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therefore, the TNF molecule may have an important genetically and/or functionally implication in the pathogenesis of BD in the Tunisian population.
|
17349875 |
2007 |
|
Behcet Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The present study was designed to explore the interrelationship between single nucleotide polymorphisms (SNP) of the tumor necrosis factor superfamily (TNFSF) and its respective receptor superfamily (TNFRSF) genes and Behcet's disease (BD) and Vogt-Koyanagi-Harada syndrome (VKH) in Han Chinese.
|
29285231 |
2017 |
|
Behcet Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The present study might suggest that TNF-α -308A/G, IL-10 -1082G/A, -819C/T, -592C/A polymorphisms are associated with BD susceptibility.
|
24267724 |
2013 |
|
Behcet Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, polymorphic analyses of the TNFB gene and Tau-a microsatellite between the HLA-B and TNF genes indicate that the pathogenic gene of BD is not the HLA-B51 gene itself but another gene located around the HLA-B gene.
|
9509902 |
1997 |
|
Behcet Syndrome
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Since NRAMP1 plays a role in the up-regulation of the TNF-alpha, iNOS and MHC expression, it may also be a candidate gene for Behçet's syndrome (BS).
|
18998137 |
2009 |
|
Behcet Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The rare TNF-2 polymorphism at the TNF -308 promoter position was associated with HLA-B*50 (not B*51), and was not associated with BD.
|
10519363 |
1999 |
|
Behcet Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Tumor necrosis factor (TNF)-blocking agents such as Infliximab, Etanercept, and Adalimumab have been reported to have success in patients with BD.
|
29631062 |
2018 |
|
Behcet Syndrome
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
When nongranulomatous uveitis (BD and HLA-B27-associated uveitis) was compared with granulomatous uveitis (sarcoidosis and VKH disease), the levels of sCD30 and sTNFRI/TNF-α and sTNFRII/TNF-α ratios were significantly enhanced in granulomatous uveitis.
|
31804623 |
2019 |
|
Behcet Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our study indicates that functional TNF-α, IL10 genotypes or combined TNF-α, IL10 genotypes do not play a role in BS susceptibility in Turkish BS patients.
|
20191386 |
2010 |
|
Behcet Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results indicated that a non-HLA gene located around the TNF gene region centromic of the HLA-B gene was a candidate to control the genetic susceptibility to Behçet's disease.
|
1356945 |
1992 |
|
Behcet Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Efficacy of tumor necrosis factor-alpha inhibitors, interferon α and anti-interleukin-1 agents was shown in noncontrolled studies of ocular Behçet disease.
|
27662569 |
2017 |
|
Behcet Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
New uncontrolled data suggest beneficial effects of anti-TNFs for refractory extra-ocular complications of BS such as pulmonary artery, gastrointestinal and central nervous system involvement.
|
27791958 |
2017 |
|
Behcet Syndrome
|
0.100 |
Biomarker
|
disease |
LHGDN |
The aim of the study is to compare stimulated production of TNF-alpha by PBM of BD patients with that of healthy volunteers (HV) and to examine correlations between the ability of PBM to produce TNF-alpha and organ/system involvement in patients with BD.
|
16897113 |
2007 |
|
Behcet Syndrome
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Among the cytokines related to innate immunity, the levels of IL-1α, IL-1 β, IL-6, IL-12, IL-15 and TNF-α were statistically higher in BD patients than healthy controls.
|
27939191 |
2017 |
|
Behcet Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Microsatellite polymorphism between the tumor necrosis factor and HLA-B genes in Behçet's disease.
|
7591872 |
1995 |
|
Behcet Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recently, novel biotherapy approaches, including interferon-α (IFN-α), tumor necrosis factor-α (TNF-α) antagonists, and other agents that target interleukins and their receptors, have shown promising results in the treatment of patients with refractory BD and have improved the prognosis of BD.
|
30984205 |
2019 |
|
Behcet Syndrome
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Six polymorphisms in the promoter region of TNFA were genotyped in 254 BD patients and 344 control subjects, via the PCR-RFLP technique.
|
16891799 |
2006 |
|
Behcet Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our findings may suggest a signature of IL-6, tumor necrosis factor-α as well as of Th17 response in BD patients due to increased levels of gp130/sIL-6Rb, sTNF-R1, sTNF-R2, IL-26, respectively.
|
28289419 |
2017 |
|
Behcet Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Among the various immunodysfunctions that are found in BD, patients are increased neutrophil motility and superoxide production, as well as elevated production of tumor necrosis factor (TNF)-α and decreased production of interleukin (IL)-10.
|
28693405 |
2017 |
|
Behcet Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
We report the first association between BD and TNF-α SNPs in Moroccan patients.
|
22711844 |
2012 |
|
Behcet Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Particular genotypes and haplotypes in TNF-α were over-represented in BD, which may, in turn, predispose individuals to this disease.
|
21059493 |
2010 |
|
Behcet Syndrome
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The pathogenesis of BD has not been fully elucidated; however, BD has been considered to be a typical Th1-mediated inflammatory disease, characterized by elevated levels of Th1 cytokines such as IFN-γ, IL-2, and TNF-α.
|
28753995 |
2017 |
|
Behcet Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
However, association of the other IL-23R polymorphisms could not be estimated owing to the lack of studies.<b>Abbreviations</b>: BD: Behcet's disease; SNP: single nucleotide polymorphism; HLA: human leukocyte antigen; IL: interleukin; OR: odds ratio; CI: confidence interval; HWE: Hardy-Weinberg equilibrium; UK: United Kingdom; NOS: Newcastle-Ottawa scale; GWAS: genome-wide association study; TNF-α: tumor necrosis factor-α.
|
31814470 |
2019 |
|
Behcet Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
No significant difference was observed in the distribution of TNF-alpha promoter region polymorphisms between patients with Behçet's disease and controls.
|
14727453 |
2004 |
|
Behcet Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We also sought to determine the effects of periodontal condition and TNF-alpha-1031T/C polymorphism on clinical severity of BD.
|
18355201 |
2008 |