|
Behcet Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results indicated that a non-HLA gene located around the TNF gene region centromic of the HLA-B gene was a candidate to control the genetic susceptibility to Behçet's disease.
|
1356945 |
1992 |
|
Behcet Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Microsatellite polymorphism between the tumor necrosis factor and HLA-B genes in Behçet's disease.
|
7591872 |
1995 |
|
Behcet Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, polymorphic analyses of the TNFB gene and Tau-a microsatellite between the HLA-B and TNF genes indicate that the pathogenic gene of BD is not the HLA-B51 gene itself but another gene located around the HLA-B gene.
|
9509902 |
1997 |
|
Behcet Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The rare TNF-2 polymorphism at the TNF -308 promoter position was associated with HLA-B*50 (not B*51), and was not associated with BD.
|
10519363 |
1999 |
|
Behcet Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This genetic proximity to a gene that is already widely implicated in disease susceptibility led us to investigate the association between TNF promoter polymorphisms and susceptibility to BD.
|
12632436 |
2003 |
|
Behcet Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this study, we investigated genetic polymorphisms of TNF alpha -308 G/A, TNF beta +252 G/A, and TNFR2 196 R/M in 94 Korean BD patients and age- and sex-matched healthy controls to investigate the role of TNF and TNF receptor polymorphisms in BD.
|
12770792 |
2003 |
|
Behcet Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
No significant difference was observed in the distribution of TNF-alpha promoter region polymorphisms between patients with Behçet's disease and controls.
|
14727453 |
2004 |
|
Behcet Syndrome
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Intestinal lesions of BD expressed interferon (IFN)-gamma, tumour necrosis factor (TNF)-alpha and interleukin (IL)-12 mRNA, indicating Th1 skewed responses in vivo. mRNA of Txk, a Tec family tyrosine kinase specific to Th1 cells, was expressed in the lesions, suggesting its contribution to the Th1-dominant responses.
|
15654837 |
2005 |
|
Behcet Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
The tumor necrosis factor alpha (TNFalpha) pathway is likely involved in the pathophysiology of Behçet's disease.
|
15692984 |
2005 |
|
Behcet Syndrome
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Six polymorphisms in the promoter region of TNFA were genotyped in 254 BD patients and 344 control subjects, via the PCR-RFLP technique.
|
16891799 |
2006 |
|
Behcet Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association of TNFA promoter region haplotype in Behçet's Disease.
|
16891799 |
2006 |
|
Behcet Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To investigate the possible relation of the TNF-alpha-1031 T/C polymorphism with susceptibility to BD in a Turkish population and to determine the functional importance of this polymorphism.
|
16882174 |
2006 |
|
Behcet Syndrome
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Serum TNF-alpha level was significantly higher in patients with BD than in healthy controls (3.10 +/- 1.45 pg/ml vs 2.43 +/- 1.94 pg/ml, P < 0.01).
|
15875188 |
2006 |
|
Behcet Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therefore, the TNF molecule may have an important genetically and/or functionally implication in the pathogenesis of BD in the Tunisian population.
|
17349875 |
2007 |
|
Behcet Syndrome
|
0.100 |
Biomarker
|
disease |
LHGDN |
The aim of the study is to compare stimulated production of TNF-alpha by PBM of BD patients with that of healthy volunteers (HV) and to examine correlations between the ability of PBM to produce TNF-alpha and organ/system involvement in patients with BD.
|
16897113 |
2007 |
|
Behcet Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Patients with the novel -646A allele of the TNFalpha promoter region were significantly associated with the expression of the HLA-B51 allele (p(corr) = 0.006), although this novel polymorphic allele was not associated with BD susceptibility.
|
17657677 |
2007 |
|
Behcet Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We also sought to determine the effects of periodontal condition and TNF-alpha-1031T/C polymorphism on clinical severity of BD.
|
18355201 |
2008 |
|
Behcet Syndrome
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Since NRAMP1 plays a role in the up-regulation of the TNF-alpha, iNOS and MHC expression, it may also be a candidate gene for Behçet's syndrome (BS).
|
18998137 |
2009 |
|
Behcet Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The single nucleotide polymorphisms of the IL-6 and IL-8 receptor genes and the TNF-alpha gene analysed here do not appear to be associated with Behçet's disease.
|
19026125 |
2009 |
|
Behcet Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest that TNF-alpha is a susceptibility gene for BD in patients from Iranian Azeri Turk ethnic group.
|
19774383 |
2009 |
|
Behcet Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our study indicates that functional TNF-α, IL10 genotypes or combined TNF-α, IL10 genotypes do not play a role in BS susceptibility in Turkish BS patients.
|
20191386 |
2010 |
|
Behcet Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Particular genotypes and haplotypes in TNF-α were over-represented in BD, which may, in turn, predispose individuals to this disease.
|
21059493 |
2010 |
|
Behcet Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A literature review was performed using MEDLINE, EMBASE and the Cochrane Central Register of Controlled Trials for original studies published in English up to October 31, 2009 and that examined the association of the TNF-alpha promoter polymorphisms with Behçet's disease.
|
20470944 |
2010 |
|
Behcet Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
We assayed aqueous humor (AH) samples from patients with Behçet's disease (BD), Vogt-Koyanagi-Harada (VKH) disease, and HLA-B27-associated uveitis and control patients for the proinflammatory cytokines IL-15, IL-17, interferon-γ and tumor necrosis factor-α and the immunosuppressive cytokine IL-10.
|
21334264 |
2011 |
|
Behcet Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Data suggest that other HLA (HLA-C, HLA-DR) and HLA-related [MHC Class I chain-related gene A (MIC-A), TNF-α] genes may play a role in BD co-susceptibility or pathogenesis.
|
21059670 |
2011 |