Stomach Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our aim was to evaluate whether IL-1 gene cluster and tumor necrosis factor-alpha (TNFA)-307 polymorphisms, as well as cagA-positive status, are associated with gastric carcinoma in a non-Caucasian population by analyzing the data in logistic regression models.
|
15704154 |
2005 |
Stomach Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Tumor necrosis factor-related apoptosis inducing ligand gene polymorphisms are correlated with gastric cancer in central China.
|
24277417 |
2015 |
Stomach Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We analyzed genotypes for HLA class I and II, tumor necrosis factor alpha, interleukin (IL)-1beta, IL-1 receptor, IL-4, IL-4Ralpha and IL-10 in 330 H. pylori-infected noncardia patients with GC and 190 H. pylori-infected nonulcer dyspeptic controls.
|
19544559 |
2009 |
Stomach Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The present study is aimed at evaluating the role of TNF-α-308 (G → A) gene polymorphism and susceptibility to GC.
|
23828749 |
2014 |
Stomach Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The IL-10-1082 gene and the GA 308 genotype of the TNF-α gene were found to be susceptibility genes for gastric cancer.
|
25526211 |
2014 |
Stomach Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Various clinicopathological factors for gastric cancer were not related to the preoperative detection of TNF in the serum.
|
7961104 |
1994 |
Stomach Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This suggests that the association between the TNFA-308G>A polymorphism and increased risk of gastric carcinoma is dependent on linkage disequilibrium with an as yet unidentified locus.
|
18768512 |
2008 |
Stomach Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These results strongly suggest that up-regulation of WNT10A induced by TNFalpha and H. pylori might play key roles in human gastric cancer through activation of WNT--beta-catenin--TCF signaling pathway.
|
11494032 |
2001 |
Stomach Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We also examined the association of TNFA polymorphism with gastric carcinoma.
|
15201584 |
2004 |
Stomach Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
PADI4 has genetic susceptibility to gastric carcinoma and upregulates CXCR2, KRT14 and TNF-α expression levels.
|
27556695 |
2016 |
Stomach Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
However, the frequencies of individual haplotypes C and D, which had opposite alleles at -1031, -863, and -857, showed statistically significant differences between the gastric cancer and duodenal ulcer (P=0.005 and P=0.02, respectively), suggesting that the TNF/LTA genotypes might play an opposite role in the pathogenesis of gastric cancer and duodenal ulcer.
|
15381184 |
2004 |
Stomach Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, TNF-α 238 G/A polymorphism is significantly associated with increased risk of gastric cancer, especially in Asians.
|
23900678 |
2013 |
Stomach Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The combined effects between the TNF gene and smoking on gastric cancer risk were also evaluated.
|
19615068 |
2009 |
Stomach Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The relative mRNA expression levels (RQ) of TNF-α, IL-8, and IL-10 were markedly downregulated in the CG group (median RQs = 0.128, 0.247, and 0.614, respectively), while the RQ levels of TNF-α in the GC group were upregulated (RQ = 2.749), but were basal for IL-8 (RQ = 1.053) and downregulated for IL-10 (RQ = 0.179).
|
26088449 |
2015 |
Stomach Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The present results indicate that targeting the TNF-α/TNFR1 pathway may be an effective preventive or therapeutic strategy for gastric cancer.
|
23975421 |
2014 |
Stomach Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our study investigates the role of the IL-1B-31, IL-1RN and TNF-A-308 gene polymorphisms as risk factors for the development of GC in a Mexican population.
|
15540224 |
2005 |
Stomach Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A gastric cancer (GC) cell line, AGS, has high-level expression of CD40, a tumor necrosis factor receptor (TNFR) family member.
|
19604505 |
2009 |
Stomach Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In the subgroup analysis, we found that TNF-α-238G/A polymorphism was associated with the increased risk of GC amongst Asians, especially in Chinese, but not in Caucasians.
|
30413607 |
2018 |
Stomach Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The TNF-α(-238) (G/A) genotype was significantly associated with a high risk of gastritis and gastric cancer (GC) (P = 0.001 and P = 0.002, resp.).
|
26504356 |
2015 |
Stomach Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In addition, we performed a meta-analysis to draw a firm conclusion about the association between TNF-α gene polymorphisms and GC.
|
28699601 |
2017 |
Stomach Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
TNF-α-G308A (rs1800629) polymorphisms are associated with gastric cancer in Chinese population.
|
27373488 |
2017 |
Stomach Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The study results revealed that IL-1β rs1143627: T > C, rs16944: C > T (p = 0.001;OR = 1.85; 95% CI 1.30-2.63) and rs1143633: G > A (p < 0.0001; OR = 2.53; 95% CI 1.67-3.83) and TNF-α rs1800630: C > A, rs1799964: T > C (p < 0.0001; OR = 2.31; 95% CI 1.54-3.46) polymorphisms significantly contributed toward GC risk.
|
30094865 |
2018 |
Stomach Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our study found that TNF-α expression may play a vital role in peritoneal metastasis of GC, while IL-1B expression might not be correlated with peritoneal metastasis.
|
26069103 |
2015 |
Stomach Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
A novel vascular-targeting peptide for gastric cancer delivers low-dose TNFα to normalize the blood vessels and improve the anti-cancer efficiency of 5-fluorouracil.
|
28970092 |
2017 |
Stomach Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, IL-1beta, IL1-RN, and TNF-alpha genotypes are not associated with gastric cancer in Italian patients.
|
15927855 |
2005 |