Stomach Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Tumor necrosis factor-related apoptosis inducing ligand gene polymorphisms are correlated with gastric cancer in central China.
|
24277417 |
2015 |
Stomach Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Tumor necrosis factor-alpha (TNF-α) is an important inflammatory cytokine that plays a role in controlling the progression of lung cancer, hepatocellular cancer, breast cancer and gastric cancer.
|
26464679 |
2015 |
Stomach Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
TNF-α-G308A (rs1800629) polymorphisms are associated with gastric cancer in Chinese population.
|
27373488 |
2017 |
Stomach Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A gastric cancer (GC) cell line, AGS, has high-level expression of CD40, a tumor necrosis factor receptor (TNFR) family member.
|
19604505 |
2009 |
Stomach Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
A novel vascular-targeting peptide for gastric cancer delivers low-dose TNFα to normalize the blood vessels and improve the anti-cancer efficiency of 5-fluorouracil.
|
28970092 |
2017 |
Stomach Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association between TNF-α-308 G/A gene polymorphism and gastric cancer risk: a systematic review and meta-analysis.
|
25125137 |
2014 |
Stomach Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Besides, TNFA-857 locus may be related to GC risk, which demonstrated changeability of results in different contrasts.
|
18350251 |
2008 |
Stomach Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Epithelial-mesenchymal transition in human gastric cancer cell lines induced by TNF-α-inducing protein of Helicobacter pylori.
|
24249671 |
2014 |
Stomach Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Functional promoter -308G>A variant in tumor necrosis factor α gene is associated with risk and progression of gastric cancer in a Chinese population.
|
23326309 |
2013 |
Stomach Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
High expression of tumor necrosis factor receptor-associated factor 2 promotes tumor metastasis and is associated with unfavorable prognosis in gastric cancer.
|
28482378 |
2018 |
Stomach Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
However, subtype-specific associations were observed for gastric cardia adenocarcinomas at MUC1/TRIM46/1q22 rs2070803 [HRAA versus GA+GG = 2.16; 95% confidence interval (CI) = 1.24-3.78; P = 0.0068] and LTA/TNF/6p21.33 rs1799724 (HRTT+CT versus CC = 1.30; 95% CI = 1.07-1.57; P = 0.0077), and for diffuse-type GC at PSCA/8q24.3 rs2294008 (HRTT versus CT+CC = 1.99; 95% CI = 1.33-2.97; P = 7.8E-04).
|
29028942 |
2017 |
Stomach Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
However, the frequencies of individual haplotypes C and D, which had opposite alleles at -1031, -863, and -857, showed statistically significant differences between the gastric cancer and duodenal ulcer (P=0.005 and P=0.02, respectively), suggesting that the TNF/LTA genotypes might play an opposite role in the pathogenesis of gastric cancer and duodenal ulcer.
|
15381184 |
2004 |
Stomach Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Human gastric cancer development with TNF-α-inducing protein secreted from Helicobacter pylori.
|
22459353 |
2012 |
Stomach Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
IL-1β-31CC, IL-1β-511TT genotype, and TNF-α-857T carrier may have protective effect against GC progression.
|
21246243 |
2011 |
Stomach Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In addition, we performed a meta-analysis to draw a firm conclusion about the association between TNF-α gene polymorphisms and GC.
|
28699601 |
2017 |
Stomach Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, TNF-α 238 G/A polymorphism is significantly associated with increased risk of gastric cancer, especially in Asians.
|
23900678 |
2013 |
Stomach Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, IL-10-1082/-592 and TNF-A-308 genetic polymorphisms may not be the important contributors to GC in Korea.
|
15978325 |
2005 |
Stomach Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, IL-1beta, IL1-RN, and TNF-alpha genotypes are not associated with gastric cancer in Italian patients.
|
15927855 |
2005 |
Stomach Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In the subgroup analysis, we found that TNF-α-238G/A polymorphism was associated with the increased risk of GC amongst Asians, especially in Chinese, but not in Caucasians.
|
30413607 |
2018 |
Stomach Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Involvement of tumor necrosis factor-alpha in the upregulation of CXCR4 expression in gastric cancer induced by Helicobacter pylori.
|
20699000 |
2010 |
Stomach Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Large meta-analyses confirmed the association between IL8, IL10, TNF-b, TP53 and PSCA, while genetic variation at different genes such as XPG, PLCE1, HFE, ERCC5, EZH2, DOC2, CYP19A1, ALDH2, and CDH1 have been reported to be associated with GC risk.
|
24011243 |
2013 |
Stomach Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
No association was noted between GC and controls in the distribution of IL-1 and TNF-alpha genotypes.
|
12594817 |
2003 |
Stomach Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Only polymorphisms at HLA-DQ, TNF and CYP2E genes may confer some protective effect against gastric cancer.
|
12115538 |
2002 |
Stomach Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our aim was to evaluate whether IL-1 gene cluster and tumor necrosis factor-alpha (TNFA)-307 polymorphisms, as well as cagA-positive status, are associated with gastric carcinoma in a non-Caucasian population by analyzing the data in logistic regression models.
|
15704154 |
2005 |
Stomach Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that two Th1-related polymorphisms (TNFA -308 A>G and IFNGR2 Ex7-128 C>T) may increase the risk of gastric cancer.
|
16885196 |
2007 |