TNF, tumor necrosis factor, 7124

N. diseases: 2724; N. variants: 31
Disease: Impaired cognition ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.100 Biomarker disease BEFREE Phase I and IIa clinical trials suggest that TNF-α inhibitors might slow down cognitive decline and improve daily activities in AD patients. 27697064 2017
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.100 Biomarker disease BEFREE Early elevations of C-reactive protein, tumor necrosis factor-α, interleukin (IL)-8, intercellular adhesion molecule (ICAM)-1, and erythropoietin were associated with IQ values >2 SD below the expected mean (ORs: 2.0-2.3) and with moderate to severe cognitive impairment on a composite measure of IQ and executive function (ORs: 2.1-3.6). 27788929 2017
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.100 Biomarker disease BEFREE Consistent with this, elevated systemic TNF-α is associated with more rapid cognitive decline over 6months in Alzheimer's disease patients. 27633985 2017
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.100 GeneticVariation disease BEFREE Impact of TNF-α (rs1800629) and IL-6 (rs1800795) Polymorphisms on Cognitive Impairment in Asian Breast Cancer Patients. 27701469 2016
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.100 Biomarker disease BEFREE Cytokines such as TNFα play an integral role in sleep/wake regulation and have recently been hypothesized to be involved in cognitive impairment due to sleep deprivation. 25542735 2015
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.100 Biomarker disease BEFREE Early intervention with a small molecule inhibitor for tumor necrosis factor-α prevents cognitive deficits in a triple transgenic mouse model of Alzheimer's disease. 22632257 2012
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.100 AlteredExpression disease BEFREE Plasma levels of soluble CD14 and tumor necrosis factor-alpha type II receptor correlate with cognitive dysfunction during human immunodeficiency virus type 1 infection. 11517430 2001