|
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
As both TNFalpha and oxidative stress independently play role in regulating cytoskeletal organization and cell survival pathways we investigated whether TNFalpha mediated oxidative stress regulates responses that offer survival advantages to glioblastoma cells.
|
19836430 |
2010 |
|
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This prompted us to evaluate the antitumor effects of recombinant parvoviruses designed to deliver IP-10 or TNF-alpha into a glioblastoma.
|
18670452 |
2009 |
|
Adult Glioblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Here, we have examined two non-chemotherapeutic agents for synergistic effects: lovastatin and Tumor Necrosis Factor (TNF)-related apoptosis-inducing ligand (TRAIL) for synergistic effects; on three human malignant glioblastoma cell lines, M059K, M59J, and A172.
|
17928957 |
2008 |
|
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
As glioblastoma are resistant to the cytotoxic effect of TNFalpha, we investigated the potential of Ebselen in sensitizing glioma cells to TNFalpha-induced apoptosis.
|
18709644 |
2008 |
|
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Growth inhibition and radiosensitization of glioblastoma and lung cancer cells by small interfering RNA silencing of tumor necrosis factor receptor-associated factor 2.
|
18794145 |
2008 |
|
Adult Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The current study examined the role of SphK activity in TNF-alpha-stimulated cell proliferation in 1321N1 glioblastoma cells.
|
17114809 |
2007 |
|
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We found that anisomycin and death receptor ligand anti-Fas antibody CH-11 or tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) synergistically induce apoptosis in multiple human glioblastoma cell lines.
|
17699104 |
2007 |
|
Adult Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Apoptosis in human glioblastoma cells produced using embryonic stem cell-derived astrocytes expressing tumor necrosis factor-related apoptosis-inducing ligand.
|
16871882 |
2006 |
|
Adult Glioblastoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Inhibition of DNA methylation sensitizes glioblastoma for tumor necrosis factor-related apoptosis-inducing ligand-mediated destruction.
|
16357155 |
2005 |
|
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Transcriptional targeting of adenovirally delivered tumor necrosis factor alpha by temozolomide in experimental glioblastoma.
|
15374943 |
2004 |
|
Adult Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Microarray analysis of tumor necrosis factor alpha induced gene expression in U373 human glioblastoma cells.
|
14641910 |
2003 |
|
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
To exploit this tropism to develop a therapeutic strategy that targeted tumor satellites, we inoculated human glioblastoma xenografts with tumor necrosis factor-related apoptosis-inducing ligand-secreting NSCs.
|
12499252 |
2002 |
|
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Effects of retinoic acid and tumor necrosis factor alpha on GL-15 glioblastoma cells.
|
10674492 |
2000 |
|
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Experiments were carried out in a nude mouse model of human glioblastoma to determine whether gamma-knife radiosurgery combined with herpes simplex virus thymidine kinase (tk) suicide gene therapy and tumor necrosis factor alpha (TNFalpha) gene transfer provided an improved multimodality treatment of this disease.
|
10947938 |
2000 |
|
Adult Glioblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Tumor necrosis factor microsatellite polymorphisms in Italian glioblastoma patients.
|
10087955 |
1999 |
|
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Triple helix-forming oligodeoxyribonucleotides targeted to the human tumor necrosis factor (TNF) gene inhibit TNF production and block the TNF-dependent growth of human glioblastoma tumor cells.
|
8912851 |
1996 |
|
Adult Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
p55 and p75 tumor necrosis factor receptor expression on human glioblastoma cells.
|
7566386 |
1995 |
|
Adult Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Modulation of proliferation and antigen expression of a cloned human glioblastoma by interleukin-4 alone and in combination with tumor necrosis factor-alpha and/or interferon-gamma.
|
8413882 |
1993 |