Cerebrovascular accident
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Recent reports suggested that tumor necrosis factor-α (TNF-α) (-308) polymorphism is an important risk factor for stroke in children with SCA.
|
21160173 |
2011 |
Cerebrovascular accident
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Serum levels of TNF-α, C-reactive protein (CRP), IL-4, IL-6, IL-10, IL-17, IL-23, and TGF-β increased, whereas serum level of IFN-γ decreased at all time points after stroke.
|
27682880 |
2017 |
Cerebrovascular accident
|
0.600 |
GeneticVariation
|
group |
LHGDN |
Susceptibility for ischemic stroke in Korean population is associated with polymorphisms of the interleukin-1 receptor antagonist and tumor necrosis factor-alpha genes, but not the interleukin-1beta gene.
|
15036607 |
2004 |
Cerebrovascular accident
|
0.600 |
GeneticVariation
|
group |
LHGDN |
The aim of this replication study was to confirm our previous findings of associations between the TNF(-308) G/A, IL4R 503 S/P, and ADRB2 27 Q/E polymorphisms and large vessel stroke risk.
|
17600229 |
2007 |
Cerebrovascular accident
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The aim of this replication study was to confirm our previous findings of associations between the TNF(-308) G/A, IL4R 503 S/P, and ADRB2 27 Q/E polymorphisms and large vessel stroke risk.
|
17600229 |
2007 |
Cerebrovascular accident
|
0.600 |
Biomarker
|
group |
BEFREE |
The aim of this study was to evaluate the association of genetic variants within the genes encoding tumor necrosis factor-α (TNF-α) and matrix metalloproteinase-3 (MMP-3), with stroke.
|
21219546 |
2011 |
Cerebrovascular accident
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The combination of TNF (-308)GG homozygosity and the IL4R 503P variant carrier status was associated with a particularly strong predisposition to LV stroke (odds ratio [OR] = 5.5; 95% confidence interval [CI] = 2.3-13.1).
|
14615367 |
2004 |
Cerebrovascular accident
|
0.600 |
Biomarker
|
group |
CTD_human |
The novel beta-blocker, carvedilol, provides neuroprotection in transient focal stroke.
|
10950380 |
2000 |
Cerebrovascular accident
|
0.600 |
Biomarker
|
group |
BEFREE |
The reduced release of TNFα and IP-10 after ex vivo blood stimulation with endotoxin is independently associated with poor outcome after stroke.
|
29275013 |
2018 |
Cerebrovascular accident
|
0.600 |
AlteredExpression
|
group |
LHGDN |
The release of tumor necrosis factor-alpha is associated with ischemic tolerance in human stroke.
|
14681891 |
2003 |
Cerebrovascular accident
|
0.600 |
Biomarker
|
group |
BEFREE |
There is increasing evidence on the role of proinflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in the occurrence and outcome of stroke.
|
15733973 |
2005 |
Cerebrovascular accident
|
0.600 |
Biomarker
|
group |
BEFREE |
These data provide evidence that serum TNF-α and IL-1β concentrations are related to poor long-term outcomes after stroke in the presence of particular alleles.
|
29161722 |
2018 |
Cerebrovascular accident
|
0.600 |
AlteredExpression
|
group |
BEFREE |
These findings indicate the important roles that TNF-α and IL-1β serum levels play regarding the risk of PSD, particularly during the acute phase of stroke and in patients with genetic susceptibility.
|
28844626 |
2017 |
Cerebrovascular accident
|
0.600 |
Biomarker
|
group |
BEFREE |
These findings strongly implicate the involvement of TNF-α in the pathogenesis of stroke.
|
23050663 |
2012 |
Cerebrovascular accident
|
0.600 |
Biomarker
|
group |
BEFREE |
This study suggests that delirium is not scarce in patients with AIS admitted to the non-intensive stroke unit, and that delirium developing after AIS seems not to be associated with serum TNF-alpha, IL-1 beta, IL-18, BDNF and NSE but is associated with length of hospital stay and stroke severity.
|
27816188 |
2017 |
Cerebrovascular accident
|
0.600 |
GeneticVariation
|
group |
BEFREE |
This study was designed to detect wether the TNF2 allele is associated with disease progression in MS. We examined the TNFalpha -308 polymorphism with an allelic discrimination PCR to detect the G-->A transition in the genomic DNA of 283 MS patients from Germany and in 72 patients with amyotrophic lateral sclerosis (ALS) and 66 with stroke from the same genetic background who served as controls.
|
10552245 |
1999 |
Cerebrovascular accident
|
0.600 |
AlteredExpression
|
group |
BEFREE |
This work was designed to examine the effect of mouse recombinant resistin on mRNA expression of Tumor necrosis factor-α (TNF-α), Interleukin-1β (IL-1β), Interleukin-10 (IL-10), Transforming growth factor-β1 (TGF- β1), and Heat shock protein-70 (HSP-70) in mouse model of stroke.
|
30120034 |
2018 |
Cerebrovascular accident
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Up-regulated TNF-α expression has also been found in various neurodegenerative diseases such as cerebral malaria, AIDS dementia, Alzheimer's disease, multiple sclerosis, and stroke, suggesting a potential pathogenic role of TNF-α in these diseases as well.
|
21298033 |
2011 |
Cerebrovascular accident
|
0.600 |
Biomarker
|
group |
BEFREE |
We also subjected TNF knockout mice to experimental stroke (permanent middle cerebral artery occlusion) and validated the effect of TNF inhibition on EV release.
|
29807527 |
2018 |
Cerebrovascular accident
|
0.600 |
Biomarker
|
group |
BEFREE |
We demonstrate that therapeutic approaches targeting synergistic IL-17 and tumor necrosis factor-α pathways in parallel offer additional neuroprotection in stroke.
|
28611085 |
2017 |
Cerebrovascular accident
|
0.600 |
Biomarker
|
group |
BEFREE |
We investigated the role of inflammatory genes IL1B, IL6, MPO, and TNF in stroke susceptibility and recovery in a population sample of 672 patients and 530 controls, adjusting for demographic, clinical and lifestyle risk factors, and stroke severity parameters.
|
21407237 |
2011 |
Cerebrovascular accident
|
0.600 |
AlteredExpression
|
group |
BEFREE |
We investigated whether gradual increases in tumor necrosis factor-alpha (TNF-alpha) reported during exercise down-regulates expression of TNF-alpha receptors I and II (TNFRI and II) in stroke, leading to reduced brain damage.
|
17109621 |
2006 |