Endometriosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Endometriosis progression in tumor necrosis factor receptor p55-deficient mice: Impact on oxidative/nitrosative stress and metallomic profile.
|
30732877 |
2019 |
Endometriosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Chronic deregulation of TNF receptors can have serious consequences for women with advanced endometriosis.
|
31070761 |
2019 |
Endometriosis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, these results suggest that CXCL16/CXCR6 axis, whose expression was enhanced by TNF-α, may be associated with the increased motility of EESCs, through regulation of ERK1/2 signaling, thus contributing to the development of endometriosis.
|
29779473 |
2019 |
Endometriosis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Enzyme-linked immunosorbent assay for tumor necrosis factor-α (TNF-α), interleukin (IL)-6, IL-8, and IL-1β levels and quantitative real-time polymerase chain reaction for expression of miRNAs 125b-5p and Let-7b-5p in sera of patients with and without endometriosis.
|
29040578 |
2018 |
Endometriosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
We conducted a case-control study nested within the Nurses' Health Study II in which we examined associations between levels of plasma inflammatory markers (interleukin-1 beta, interleukin-6, soluble tumor necrosis factor α receptors 1 and 2, and high-sensitivity C-reactive protein) and the risk of laparoscopically confirmed endometriosis.
|
28992341 |
2018 |
Endometriosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Results of ELISA showed that the levels of IL-6, IL-10, IL-13, and TNF-α in peritoneal fluid of endometriosis patients complicated with infertility were significantly higher than those in control group (p<0.05).
|
29771400 |
2018 |
Endometriosis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
No significant difference was observed in genotypic or allelic frequencies between control and endometriosis groups for rs498679 (TLR4 gene), rs1799964 (TNF-α gene), rs3024496 (IL-10 gene), neither when comparing endometriosis subgroups (I-II versus III-IV).
|
28470452 |
2017 |
Endometriosis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
ESC from endometrial biopsies of six subjects with histologically confirmed endometriosis were treated for 6 h with medium alone or with TNF-α (10 or 100 ng/ml) in the presence of dienogest (DNG), medroxyprogesterone acetate (MPA) and norethisterone acetate (NETA) 10-5 M. The progestin-mediated change in IL6, IL8 and MCP-1 mRNA transcription was measured, as was the PRA, PRB, GR, AR and MCR protein expression.
|
28412861 |
2017 |
Endometriosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Endometrial stromal cells (ESC) isolated from women with endometriosis were cultured with TNF-α to simulate an inflammatory environment.
|
27515307 |
2016 |
Endometriosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
The PR-B/A ratio was significantly decreased by treatment with either TNF-α (p=0.011) or peritoneal fluid from women with advanced-stage endometriosis (p=0.027).
|
27593876 |
2016 |
Endometriosis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Using primary endometrial stromal cells isolated from women with endometriosis we examined the mRNA and protein expression of the progesterone receptors A and B, membrane progesterone receptors 1 and 2, androgen receptors, mineralocorticoid receptors and glucocorticoid receptors after exposure to the inflammatory cytokines tumor necrosis factor α (TNFα) and interleukin 1β (IL-1β).
|
27371899 |
2016 |
Endometriosis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
We studied tumor necrosis factor (TNF)-α, TNF receptor (TNFR) 1, and TNFR2 gene expression at both messenger RNA (mRNA) and protein levels in peritoneal fluid (PF) mononuclear cells (PFMCs), the percentages of these cells bearing the same markers, and soluble TNF-α (sTNF-α) values in PF of 80 women with endometriosis.
|
24844917 |
2015 |
Endometriosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
DAPK1 knockdown in endometriosis CRL-7566 cells can weaken its response to TNF-α induced cell death, while its overexpression in endometrioid cancer cells CRL-11731 enhanced the response.
|
26191186 |
2015 |
Endometriosis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
TNFα and its downstream NFκB pathway have proven to be critical regulators of highly expressed cIAP-2 in ESCs. cIAP-2 may be a novel therapeutic target for endometriosis.
|
24382102 |
2014 |
Endometriosis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
No associations were detected between the TNF-α-308A/G and IL-6 -634C/G polymorphisms and susceptibility to endometriosis.
|
24308758 |
2014 |
Endometriosis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
For TNF-a -850T>C, results from one study showed that patients harboring the heterozygote TC were less susceptible to endometriosis than patients harboring the homozygote TT.
|
24791888 |
2014 |
Endometriosis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Interactions between elevated peritoneal fluid TNF-α and overexpression of follicular Egr1/EGR1 expression may affect downstream protease pathways impeding ovulation in endometriosis.
|
23427178 |
2013 |
Endometriosis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Correlation analysis showed that the gene expression levels of hBD-2 in the ectopic and eutopic endometrium of EMS patients were positively correlated with the gene expression levels of IL-1β and TNF-α (P < 0.01).
|
23269356 |
2013 |
Endometriosis
|
0.300 |
Biomarker
|
disease |
RGD |
Interactions between elevated peritoneal fluid TNF-α and overexpression of follicular Egr1/EGR1 expression may affect downstream protease pathways impeding ovulation in endometriosis.
|
23427178 |
2013 |
Endometriosis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Endometriosis is not associated with gene mutations for p53codon72, TNF-308 G/A, VEGF-1154G/A, SOD Ala16Val.
|
23167810 |
2013 |
Endometriosis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Tachykinin mRNA (TACR1/2) and protein (neurokinin 1 receptor [NK1R]) expression in both eutopic and ectopic endometrial tissue from patients with endometriosis and the correlation to peritoneal fluid TNFα were measured.
|
23553861 |
2013 |
Endometriosis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that the TNF-α -1031T/C polymorphism was associated with susceptibility to endometriosis in Iranian population, and the -1301C allele may have a protective role in development of endometriosis; On the contrary, we find no association between the VEGF +450G/C polymorphism and risk of endometriosis.
|
23952049 |
2013 |
Endometriosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
To assess these immune responses, we evaluated the levels of expression of Toll-like receptors (TLR)-1, -2, -4, -5, and -9; nucleotide-binding oligomerization domains (NOD)-1 and -2; interleukins-1β, -6, -8, -10, and -12; interferon-γ; tumor necrosis factor-α; inducible nitric oxide synthase (iNOS) and endothelial NOS (eNOS); and immunoglobulins (Igs) in patients with endometriosis.
|
23935397 |
2013 |
Endometriosis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Regulation of P21-activated kinase-4 by progesterone and tumor necrosis factor-α in human endometrium and its increased expression in advanced-stage endometriosis.
|
23293332 |
2013 |
Endometriosis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Association between endometriosis and polymorphisms in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), TRAIL receptor and osteoprotegerin genes and their serum levels.
|
22392486 |
2012 |