Congestive heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
The interplay of tumour necrosis factor-α (TNF-α) and oxidative stress was related to severities of coronary atherosclerosis and congestive heart failure.
|
31494339 |
2020 |
Congestive heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Expression levels of IL-1ß, IL-6, TNF-alpha, and BAX mRNA were significantly associated with the degree of CHF.
|
30968846 |
2019 |
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Tumor necrosis factor-α (TNF-α) is a biomarker of inflammation that occurs in patients suffering from heart failure (HF).
|
30744018 |
2019 |
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Adult male wild-type C57BL/6 mice, Foxp3-diphtheria toxin receptor transgenic mice, and tumor necrosis factor (TNF) α receptor-1 (TNFR1)<sup>-</sup><sup>/-</sup> mice underwent nonreperfused myocardial infarction to induce HF or sham operation.
|
30586716 |
2019 |
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
So far, it has been found that inflammatory cytokines associated with the heart failure mechanism include TNF-<i>α</i>, IL-6, IL-8, IL-10, IL-1<i>α</i>, IL-1<i>β</i>, IL-2, TGF-<i>β</i>, and IFN-<i>γ</i>.
|
31275453 |
2019 |
Congestive heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In addition, the levels of IL-6, TNF-α and IL-1β decreased to 154.41 ± 7.72 pg/mg protein, 110.02 ± 6.96 pg/mg protein and 39.39 ± 5.27 pg/mg protein, respectively; the relative activity of p38 MAPK decreased to 2.60 ± 0.40 in CHF + SOJ group.
|
30860934 |
2019 |
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Inflammation is a central process in the pathophysiology of heart failure (HF), but trials targeting tumour necrosis factor (TNF)-α were largely unsuccessful.
|
31087601 |
2019 |
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
In this review, we describe available data on the occurrence of adverse events associated with TNF inhibitor treatment in ankylosing spondylitis, including serious adverse events, infections, serious infections, tuberculosis, opportunistic infections, hepatitis B reactivation, malignancies, laboratory test abnormalities, autoimmune diseases, paradoxical adverse events, and heart failure.
|
30476367 |
2019 |
Congestive heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Patients with MI and HF had reduced serum irisin, LVEF, and HDL-C and higher levels of BMI, WHR, SBP, DBP, troponin-I, creatine kinase-MB (CK-MB), TNF-α, TC, TGs, and LDL-C compared with control.
|
30958967 |
2019 |
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
The protective and anti-inflammatory effects of TNFR2 may explain why TNF inhibitors failed to be effective in diseases such as heart failure or multiple sclerosis, where TNF has been strongly implicated as a driving force.
|
30856027 |
2019 |
Congestive heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Last, PNA5 treatment decreased VCID/HF-induced activation of brain microglia/macrophages and inhibited circulating tumor necrosis factor <i>α</i>, interleukin (IL)-7, and granulocyte cell-stimulating factor serum levels while increasing that of the anti-inflammatory cytokine IL-10.
|
30709867 |
2019 |
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
A functional analysis of T cells from patients with acute HF revealed that the CD4<sup>+</sup>CD57<sup>+</sup> T cell population exhibited a higher frequency of IFN-γ- and TNF-α- producing cells compared to the CD4<sup>+</sup>CD57<sup>-</sup> T cell population.
|
31501486 |
2019 |
Congestive heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The elevated level of TNF-α in the brain and circulation in heart failure (HF) suggests an increase in the TACE-mediated ectodomain shedding process.
|
31154904 |
2019 |
Congestive heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
There was a positive correlation between TNFα and IL-6 levels in CHF patients and severity of CHF in patients.
|
28889349 |
2018 |
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
In this review, we explore the emerging role of tumor necrosis factor receptor-associated factor 6 (TRAF6)-nuclear factor kappa B (NF-κB) signaling axis in atherosclerosis, ischemic heart disease, pathologic cardiac hypertrophy or heart failure, myocarditis, and sepsis-induced cardiomyopathy.
|
29175266 |
2018 |
Congestive heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
miRNA-130a improves cardiac function by down-regulating TNF-α expression in a rat model of heart failure.
|
30556887 |
2018 |
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Tumor necrosis factor-α (TNF-α) contributes to the genesis of heart failure and impairs mitochondria.
|
29613828 |
2018 |
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
RGD |
ExT reduced by 59% TNF-α level in Tr-HF group (MD -1.7; 95% CI -2.9 to -0.3) and increased IL-10 (MD 15; 95% CI 11-26) when compared with the Sed-HF group.
|
28939262 |
2018 |
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
CTD_human |
TLR2 and TLR3 expression as a biomarker for the risk of doxorubicin-induced heart failure.
|
29959987 |
2018 |
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
The role of TNF in CHF and RA differs substantially with regard to the source and pathophysiological function of the cytokine in both conditions, therefore negative data from CHF studies should be interpreted with caution.
|
29895751 |
2018 |
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Studies have shown co-relationship between severity of heart failure and levels of the proinflammatory cytokine TNFα and one of its secondary mediators interleukin-6 (IL-6), suggesting their potential as biomarkers.
|
30259192 |
2018 |
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Decreased anabolism because of alterations in the insulin-like growth factor 1 (IGF-1)/growth hormone (GH) axis and increased catabolism induced by proinflammatory cytokines like tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6) have been reported to contribute to muscle wasting in chronic heart failure (CHF).
|
28695463 |
2017 |
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
This study aimed to compare the effects of exercise intensity and duration on the inflammatory markers soluble tumor necrosis factor receptor (sTNFR1) and interleukin-6 (IL-6), and on oxidative stress [malondialdehyde (MDA) and antioxidant enzymes: catalase (CAT) and superoxide dismutase (SOD)] in individuals with CHF.
|
28793058 |
2017 |
Congestive heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
RT-PCR showed that the mRNA expressions of TNF-α, Fas and FasL in heart failure group were significantly higher than those in normal group.
|
28925471 |
2017 |
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Despite these well-described observations, less is known about the mechanistic underpinnings of proinflammatory cytokines especially TNFα in pathogenesis of HF.
|
28763371 |
2017 |