|
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Here, we found that H3K79me2/3 modification levels at the Il6 and Ifnb1 promoters, as well as H3K79me2 modification at the Tnfα promoter, were increased in macrophages activated by Toll-like receptor (TLR) ligands or virus infection.
|
30275539 |
2020 |
|
Virus Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The multiple adverse effects of TNF-α inhibition have been identified, including a two-to four-fold increased risk of active tuberculosis and other granulomatous conditions and an increased occurrence of some other serious bacterial, fungal and certain viral infections.
|
30732563 |
2019 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Interestingly, we observed an increase in the frequency of either CD4<sup>+</sup> or CD8<sup>+</sup> T cells producing TNF-α after immunization with the pE1D2 and challenge with DENV2, while lymphocytes from pcTPANS1-vaccinated animals maintained ordinary TNF-α production after virus infection.
|
31333657 |
2019 |
|
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Lack of T-cell-mediated IL-2 and TNFα production is linked to decreased CD58 expression in intestinal tissue during acute simian immunodeficiency virus infection.
|
30480508 |
2019 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Generally, CD8 T cells can control viral infection through several mechanisms, including direct cytotoxicity, and production of pro-inflammatory cytokines such as IFN-γ and TNF-α.
|
31552052 |
2019 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
P38 and JNK Mitogen-Activated Protein Kinases Interact With Chikungunya Virus Non-structural Protein-2 and Regulate TNF Induction During Viral Infection in Macrophages.
|
31031770 |
2019 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Here, using ELISA and two CBAs commercially available, we measured TNF-α concentrations in plasma and serum from children with acute dengue virus infection and healthy controls.
|
27788058 |
2018 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The detection of cytokines interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), interleukin-12 (IL-12), interleukin-4 (IL-4) and interleukin-10 (IL-10) indicates that NDV significantly induces Th1 responses and lowers Th2 responses.
|
29481983 |
2018 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
A host-protein signature comprising tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), interferon gamma-induced protein-10 (IP-10), and C-reactive protein (CRP) was validated recently for differentiating bacterial from viral disease.
|
29700762 |
2018 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
These results suggest that the asynchronous actions of two branches of the unfolded protein response (UPR), namely, IRE1α, and PERK, activated by ER stress resulting from the virus infection, are associated with enhancement or suppression of TNF-α production, respectively.<b>IMPORTANCE</b> The activation of AMϕ is controlled by the microenvironment to deter excessive proinflammatory cytokine responses to microbes that could impair lung function.
|
29070690 |
2018 |
|
Virus Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Genetic Polymorphisms of Tumor Necrosis Factor Alpha and Susceptibility to Dengue Virus Infection in a Mexican Population.
|
28650708 |
2017 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
A novel assay that integrates measurements of blood-borne host-proteins (tumor necrosis factor-related apoptosis-inducing ligand, interferon γ-induced protein-10, and C-reactive protein [CRP]) was developed to assist in differentiation between bacterial and viral disease.
|
28904072 |
2017 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
However, a limited response to TNF-α and viral infection, but not to LPS, was observed in mouse embryonic stem cell-differentiated fibroblasts.
|
28130495 |
2017 |
|
Virus Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Inconsistency of reported associations between the tumor necrosis factor-alpha-308 (TNFα-308) polymorphism (rs1800629) and dengue virus infection prompted a meta-analysis, to obtain more precise estimates.
|
28495402 |
2017 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Although a number of cell types are able to produce TNF, the ability of CD8+ T cells to produce TNF following viral infection is a hallmark of their effector function.
|
28886201 |
2017 |
|
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The results point to the signaling route involving TLR3, MIF, and TNFα being active in TBE virus infection and contributing to the risk of an overt neuroinvasive disease.
|
28646884 |
2017 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Synergistic Effect of TNF-α and Dengue Virus Infection on Adhesion Molecule Reorganization in Human Endothelial Cells.
|
27580574 |
2017 |
|
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Notably, co-infections led to a significant increase in the levels of TNF-α and IL-6, cytokines that are widely considered to play a crucial role in the early pathogenesis of both viral diseases.
|
28644900 |
2017 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Tumour necrosis factor-α (TNF-α), a pro-inflammatory cytokine has been implicated in the pathophysiology of several viral infections.
|
25559996 |
2016 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Tumor-necrosis factor impairs CD4(+) T cell-mediated immunological control in chronic viral infection.
|
26950238 |
2016 |
|
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The pre-treatment of HeLa monolayer with inactivated bacterial cells 24 hours before the viral infection is increasing the expression level of TNF-a, IL-6 and IL-8 pro-inflammatory cytokines genes, also suggesting that bacterial antigens could contribute to the decrease of viral multiplication rate.
|
26193210 |
2015 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The TNF gene was associated with disease severity, whereas IL1B and IL6 SNPs were associated with influenza A (H1N1) virus infection.
|
26657940 |
2015 |
|
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Taken together, our data demonstrate that SVV interferes with tumor necrosis factor alpha (TNF-α)-induced NF-κB activation at multiple levels, which is consistent with the importance of these countermechanisms for varicella virus infection.
|
26085158 |
2015 |
|
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The cytoplasmic signaling protein tumor necrosis factor (TNF) receptor-associated factor 5 (TRAF5), which was identified as a signal transducer for members of the TNF receptor super-family, has been implicated in several biological functions in T/B lymphocytes and the innate immune response against viral infection.
|
24038435 |
2014 |
|
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Tumor necrosis factor alpha (TNF-α) is highly expressed during influenza virus infections and is considered an anti-infective cytokine.
|
24657783 |
2014 |