|
Chronic Periodontitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The SCP group presented higher serum ratios of tumor necrosis factor (TNF)-α/interleukin (IL)-4, TNF-α/IL-5, IL-17/IL-13 and IL-6/IL-13 (p < 0.05) than the CP group.
|
29737428 |
2019 |
|
Chronic Periodontitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Protein concentrations of IL-1β, IL-6 and TNF-α were measured in corresponding samples of GCF, gingival tissue and serum from 125 subjects with chronic periodontitis by multiplex immunoassay.
|
30362297 |
2019 |
|
Chronic Periodontitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We identified several potential biomarkers for CP diagnosis and prognosis (e.g., CSF3, CXCL12, IL1B, MS4A1, PECAM1, and TAGLN) and upstream regulators of biomarker candidates for CP diagnosis (TNF and TGF2).
|
30922293 |
2019 |
|
Chronic Periodontitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Non-surgical periodontal treatment significantly reduced the serum ACPA (p = 0.015) and TNF-α levels (p = 0.026) in CP patients, particularly in patients with generalized CP.
|
29174174 |
2018 |
|
Chronic Periodontitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The other polymorphisms like rs1799724 (-857C/T) and rs1799964 (-1031T/C) were significantly different between chronic periodontitis patients and control subjects.<b>Conclusion:</b> The findings suggest that the rs1800629 (-308G/A) polymorphism of TNF-α gene is associated with both aggressive and chronic periodontitis while rs1799724 (-857C/T) and rs1799964 (-1031T/C) polymorphisms of TNF-α gene is associated only with the increased susceptibility to chronic periodontitis.
|
29449347 |
2018 |
|
Chronic Periodontitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
IL-4 and IL-6 serum levels were significantly lower in patients with CPD and LR than in patients without CPD but with LR; IFN-γ serum levels were higher in patients with CPD and LR than in patients with no CPD and no LR; IL-4 serum levels were negatively correlated with TNF-α gene expression, while IL-6 serum levels were positively correlated with IFN-γ gene expression, in the skin of subjects with CPD and LR.
|
30427403 |
2018 |
|
Chronic Periodontitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Effects of Systemic Simvastatin on the Concentrations of Visfatin, Tumor Necrosis Factor-<i>α</i>, and Interleukin-6 in Gingival Crevicular Fluid in Patients with Type 2 Diabetes and Chronic Periodontitis.
|
30186882 |
2018 |
|
Chronic Periodontitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
SAA and TNF-α levels in GCF and serum were significantly higher in patients with gingivitis and CP compared with controls (P < 0.016).
|
27998014 |
2017 |
|
Chronic Periodontitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Dietary supplementation with low-dose omega-3 fatty acids reduces salivary tumor necrosis factor-α levels in patients with chronic periodontitis: a randomized controlled clinical study.
|
28177133 |
2017 |
|
Chronic Periodontitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Concentration of salivary markers IL-1β, TNF-α, and NO was similar in individuals with and without CP.
|
28492359 |
2017 |
|
Chronic Periodontitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The use of the vector ultrasonic system in the non-surgical treatment of chronic periodontitis presents beneficial improvements for the clinical attachment level and the probing pocket depth as well as TNF-α levels in GCF.
|
29442464 |
2017 |
|
Chronic Periodontitis
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
The aim of the present study was to evaluate whether there is a unique methylation profile of the TNF-α gene promoter in blood cells of individuals with CP and RA.
|
26247485 |
2016 |
|
Chronic Periodontitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
By comparing with the microarray dataset, we identified several CP-associated novel genes (e.g., FACR and CUX1) that have functions to interact with invading microorganisms or enhance TNF production on lipopolysaccharide stimulation.
|
26812355 |
2016 |
|
Chronic Periodontitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms of: 1) FCGR2A 131His/Arg (rs1801274); 2) FCGR2B rs1050501" genes_norm="2213">232Ile/Thr (rs1050501); 3) TNFA -1031T/C (rs1799964); and 4) TNFA -863C/A (rs1800630) were analyzed among patients with healthy gingiva (n = 176) and patients with CP (n = 177).
|
27063995 |
2016 |
|
Chronic Periodontitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Porphyromonas gingivalis (Pg), one of the main periopathogens, initiates an inflammatory cascade by host immune cells thereby increasing recruitment and activity of osteoclasts, the bone resorbing cells, through enhanced production of the crucial osteoclastogenic factor, RANK-L. Antibodies directed against some cytokines (IL-1β, IL-6 and TNF-α) failed to exhibit convincing therapeutic effect in CP.
|
27992569 |
2016 |
|
Chronic Periodontitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The purpose of this study was to determine the differences in the distribution of TNF-α (-308) gene polymorphism among aggressive periodontitis, chronic periodontitis and periodontally healthy individuals and also to investigate whether this polymorphism is associated with gingival crevicular fluid TNF-α levels and periodontal disease severity.
|
25647273 |
2015 |
|
Chronic Periodontitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
No association was found of TNF-alpha -857C/T and -238G/A polymorphisms with susceptibility to AgP or CP.
|
23973890 |
2013 |
|
Chronic Periodontitis
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
In gingival biopsies from individuals with severe CP, two individual cytosine-guanine dinucleotides (CpG sites) within the TNFA promoter (at -163 and -161 bp) displayed increased methylation in CP samples compared to those with gingival health (16.1% ± 5.1% versus 11.0% ± 4.6%, P = 0.02 and 19.8% ± 4.1% versus 15.4% ± 3.6%, P = 0.04, respectively).
|
23368949 |
2013 |
|
Chronic Periodontitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to investigate the genetic relationship between interleukin-10 (IL-10) and tumor necrosis factor alpha (TNF-α) polymorphisms and patient susceptibility to chronic periodontitis or implant failure and to compare their immunogenetic functions.
|
22010076 |
2012 |
|
Chronic Periodontitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The results suggest that the IL-6 gene polymorphism may be associated with chronic periodontitis, and that TNF-alpha gene polymorphism may not be involved in the progression of chronic periodontitis in the population of elderly Brazilian women.
|
19555357 |
2010 |
|
Chronic Periodontitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In patients with poor glycemic control, TNF-alpha, CCR5, and CXCR3 mRNAs were increased in sites with CP (P <0.01).
|
20059422 |
2010 |
|
Chronic Periodontitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This study investigated the influence of genetic (MMP1-1607 SNP), microbial (Porphyromonas gingivalis, Treponema denticola, Tannerella forsythia, Actinobacillus actinomycetemcomitans) and inflammatory [tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta)] factors on the determination of MMP-1 mRNA levels in periodontal tissues of non-smoker chronic periodontitis (CP, N=178) and control (C, N=190) groups.
|
19659894 |
2009 |
|
Chronic Periodontitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this study, we investigated the effect of the tumor necrosis factor-alpha (TNFA) -308G/A gene polymorphism and of periodontopathogens on the tumor necrosis factor-alpha levels in the periodontal tissues of nonsmoking patients with chronic periodontitis (n = 127) and in control subjects (n = 177).
|
19076989 |
2009 |
|
Chronic Periodontitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Polymorphisms in the interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha) genes have been associated with an increased severity of chronic periodontitis.
|
17823082 |
2007 |
|
Chronic Periodontitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Levels of immunoglobulin A1 and messenger RNA for interferon gamma and tumor necrosis factor alpha in total saliva from patients with diabetes mellitus type 2 with chronic periodontal disease.
|
16677285 |
2006 |