TNF, tumor necrosis factor, 7124

N. diseases: 2724; N. variants: 31
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0338480
Disease: Common Migraine
Common Migraine
0.190 GeneticVariation disease BEFREE TNF-α-857 CT genotype was associated with increased risk of MO, or MA in females or males. 25434717 2015
CUI: C0338480
Disease: Common Migraine
Common Migraine
0.190 GeneticVariation disease BEFREE Studies eligible for this meta-analysis were searched in the PubMed, Embase, and CNKI by using the keywords "tumor necrosis factor", "TNF", "252A>G", "rs909253", "polymorphism", "polymorphisms", "variant", "SNP", combined with "migraine" or "migraine with aura (MA)" or "migraine without aura (MO)". 24959879 2014
CUI: C0338480
Disease: Common Migraine
Common Migraine
0.190 GeneticVariation disease BEFREE Subgroup analyses suggested that the A allele of the TNFα -308G > A variant more than doubles the risk for migraine among populations with a heterogeneous ethnic background, which was driven by associations for migraine without aura (additive model: pooled OR = 2.87, 95% CI 1.86-4.43). 22001640 2011
CUI: C0338480
Disease: Common Migraine
Common Migraine
0.190 GeneticVariation disease BEFREE In conclusion, the present results indicate the possible contribution of TNF-alpha and IL-1beta gene polymorphisms to migraine headache generation in MwoA patients. 20113413 2010
CUI: C0338480
Disease: Common Migraine
Common Migraine
0.190 GeneticVariation disease BEFREE To assess the possibility of an association between TNF gene polymorphisms and migraine without aura, a case-control study was performed in a Sardinian sample. 19253056 2009
CUI: C0338480
Disease: Common Migraine
Common Migraine
0.190 GeneticVariation disease BEFREE Among active migraine with aura, the odds ratios (95% confidence intervals) were 1.35 (1.0 to 1.81) for TNF rs1800750, 1.13 (1.02 to 1.26) for TNF rs1800629, and 1.22 (1.07 to 1.40) for CCR2 rs1799864; among active migraine without aura, 0.9 (0.84 to 0.97) for TGFB1 rs1800469, 1.13 (1.01 to 1.27) for NOS3 rs3918226, and 1.12 (1.02 to 1.24) for IL9 rs2069885. 19559392 2009
CUI: C0338480
Disease: Common Migraine
Common Migraine
0.190 GeneticVariation disease LHGDN In conclusion, this study demonstrates an association of tumor necrosis factor-alpha (-308A) carriage with MWA, suggesting that carrying a high responder TNF-alpha-308A allele may be a genetic factor in increasing the susceptibility to develop MWA. 17063315 2006
CUI: C0338480
Disease: Common Migraine
Common Migraine
0.190 Biomarker disease BEFREE In conclusion, this study demonstrates an association of tumor necrosis factor-alpha (-308A) carriage with MWA, suggesting that carrying a high responder TNF-alpha-308A allele may be a genetic factor in increasing the susceptibility to develop MWA. 17063315 2006
CUI: C0338480
Disease: Common Migraine
Common Migraine
0.190 GeneticVariation disease LHGDN Association between the tumor necrosis factor-alpha -308 G/A gene polymorphism and migraine. 14718719 2004
CUI: C0338480
Disease: Common Migraine
Common Migraine
0.190 GeneticVariation disease BEFREE Tumor necrosis factor (TNF)-308 (TNF-308A and TNF-308G alleles) and lymphotoxin alpha (TNFB*1 and TNFB*2 alleles) polymorphisms were analyzed by the NcoI-cleaved polymerase chain reaction-amplified fragments in 47 patients with migraine without aura, 32 patients with migraine with aura, and 101 migraine-free controls. 12047333 2002
CUI: C0338480
Disease: Common Migraine
Common Migraine
0.190 Biomarker disease HPO