Endotoxemia
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
Plasma cytokine concentrations increased profoundly during endotoxaemia (control group: tumor necrosis factor alpha [TNF-α] from 14 [9-16] pg ml<sup>-1</sup> at baseline to 480 [284-709] pg ml<sup>-1</sup> at 1.5 h after LPS; interleukin-6 [IL-6] from 4 [4-4] pg ml<sup>-1</sup> at baseline to 659 [505-1018] pg ml<sup>-1</sup> at 2 h after LPS).
|
31084985 |
2019 |
Endotoxemia
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
In vivo, levels of IL-1β, IL-6, and TNFα in the lungs and liver were markedly reduced during endotoxemia in IL-37Tg mice but not observed in IL-37D20ATg mice.
|
30792349 |
2019 |
Endotoxemia
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
In accordance with that observation, we found that mice with genetic ablation of Tnf in basophils exhibited reduced systemic concentrations of TNF during endotoxemia.
|
30664762 |
2019 |
Endotoxemia
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
Female Sprague-Dawley rats were subjected to low-grade endotoxemia (i.p. injection LPS 0.5 mg kg<sup>-1</sup> body weight) and severe endotoxemia (i.p. injection LPS 8 mg kg<sup>-1</sup> body weight) for 6 h. Blood NO, as well as cardiac TNF-α and IL-1β mRNA, were found increased as the severity of the endotoxemia increases.
|
31428876 |
2019 |
Endotoxemia
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
In vivo intestinal permeability (ovalbumin [OVA] assay) and systemic inflammation and endotoxemia (TNF-α and LPS plasma levels) are assessed.
|
30656830 |
2019 |
Endotoxemia
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
The inhalation of sevoflurane inhibited increases in myeloperoxidase (MPO), macrophage inflammatory protein-2 (MIP-2), TNF-α, and IL-1β levels (P < 0.05) induced by endotoxemia, whereas IL-6 release was facilitated.
|
31425341 |
2019 |
Endotoxemia
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
20TT in the heat increased I-FABP and elevated inflammatory cytokines (IL-6 and TNF-α) compared to pre-exercise values but did not result in endotoxemia.
|
31565753 |
2019 |
Endotoxemia
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
The α7 nAChR partial agonist GTS-21 reduces secretion of pro-inflammatory cytokines including interleukin-6 (IL6) and tumor-necrosis factor (TNF) in models of endotoxemia and sepsis, and its anti-inflammatory effects are widely ascribed to α7 nAChR activation.
|
30947238 |
2019 |
Endotoxemia
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
Selective stimulation of acetylcholine action on the M1 muscarinic acetylcholine receptor (M1 mAChR) by central administration of the positive allosteric modulator benzyl quinolone carboxylic acid (BQCA) suppressed serum TNF (TNFα) levels in murine endotoxemia.
|
31024522 |
2019 |
Endotoxemia
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
Ultralow dose dextromethorphan also significantly reduced serum alanine aminotransferase activity, TNF-α level and liver cell damage of endotoxemia mice.
|
30822415 |
2019 |
Endotoxemia
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
Moreover, the expression of TNF-α and IFN-γ in the splenocytes was significantly downregulated along with improving host survival against the LPS-induced lethal endotoxemia in the same way.
|
31593353 |
2019 |
Endotoxemia
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
This study investigated (i) the nicotine modulation of hemodynamic and renal vasodilatory responses to endotoxemia in rats, and (ii) roles of α7 or α4β2-nAChRs and related HSP70/TNFα/iNOS signaling in the interaction.
|
31377559 |
2019 |
Endotoxemia
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
In a LPS-induced endotoxemia mouse model, a single intraperitoneal injection of Cl-EE (75-300 mg/kg) could lower circulatory TNF-α, IL-6 and MCP-1 levels.
|
31842849 |
2019 |
Endotoxemia
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
Plasma claudin-3 is associated with tumor necrosis factor-alpha-induced intestinal endotoxemia in liver disease.
|
31053499 |
2019 |
Endotoxemia
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
It alleviated tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in activated macrophages by downregulating the NF-κB activity, and it reduced the mortality rate in LPS induced endotoxemia mice.
|
30297806 |
2018 |
Endotoxemia
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
Here, we observed that electrical vagus nerve stimulation with a duration of 0.1-60 s significantly reduced systemic TNF release in experimental endotoxemia.
|
30538698 |
2018 |
Endotoxemia
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
In addition, it resulted in the reduction of endotoxemia (through lipopolysaccharides (LPSs)) and pro-inflammatory cytokine (tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), and interleukin 1β (IL-1β)) levels, with the increased expression of tight-junction associated proteins (claudin-1, occludin, and zonula occludens-1).
|
30065236 |
2018 |
Endotoxemia
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
As proof of concept for the therapeutic potential of our delivery system, we employed scL delivering an siRNA targeting tumor necrosis factor alpha to suppress neuroinflammation and neuronal apoptosis and to protect mice in lethal endotoxemia triggered by bacterial lipopolysaccharide.
|
29103910 |
2018 |
Endotoxemia
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
Furthermore, therapeutic studies in a systemic endotoxemia model demonstrated that mSPAM treatment reduced TNF-α and IL-6 inflammatory cytokines in serum, in turn circumventing organ damage done by the inflammatory macrophages.
|
30247915 |
2018 |
Endotoxemia
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
The lack of bile in the gut, the disruption of the intestinal mucosal barrier, the increased absorption of endotoxin and the subsequent endotoxemia cause proinflammatory cytokine production (TNF-α, IL-6).
|
29428098 |
2018 |
Endotoxemia
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
Vitamin D deficiency and up-regulated TNFα-related signals are reported to be involved in abnormalities including intestinal hyper-permeability, bacterial translocation, systemic/portal endotoxemia, intestinal/adipose tissue/hepatic inflammation, and hepatic steatosis in nonalcoholic steatohepatitis (NASH).
|
29684027 |
2018 |
Endotoxemia
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
Further, Adrb2<sup>-</sup><sup>/</sup><sup>-</sup> animals rapidly succumbed to endotoxemia in response to a sub-lethal LPS challenge and exhibited elevated serum levels of TNF-α and reduced IL-10.
|
30195028 |
2018 |
Endotoxemia
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
In a murine endotoxemia model, AWRK6 offered satisfactory protection efficiency against endotoxemia death, and the serum levels of LPS, IL-1β, IL-6, and TNF-α were found to be attenuated using ELISA.
|
29463000 |
2018 |
Endotoxemia
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
Using the microelectrode in vivo, high fidelity signals were recorded during physiological challenges (e.g potassium chloride and interleukin-1β), and electrical stimulation of the vagus nerve produced the expected significant reduction of blood levels of tumor necrosis factor (TNF) in endotoxemia.
|
28628030 |
2017 |
Endotoxemia
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
In a model of endotoxemia in the mouse, treatment with glycerophosphoinositol reduced TNF-α synthesis, which supports the concept that glycerophosphoinositol inhibits the <i>de novo</i> synthesis of proinflammatory and prothrombotic compounds and might thus have a role as an endogenous mediator in the resolution of inflammation.
|
28600357 |
2017 |