TNF, tumor necrosis factor, 7124

N. diseases: 2724; N. variants: 31
Disease: Progression of prostate cancer ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1739135
Disease: Progression of prostate cancer
Progression of prostate cancer 		0.040 Biomarker disease BEFREE There was no significant difference in the mRNA and protein levels of iNOS, VEGF, AR and IL-2, IL-8 and TNF-α between PCa and BPH+HP groups (p > .05). iNOS, VEGF, AR and IL-2, IL-8 and TNF-α are involved in the malignant transformation of prostate tissue and play an important role in the development and progression of Prostate cancer (PCa). 29441606 2018
CUI: C1739135
Disease: Progression of prostate cancer
Progression of prostate cancer 		0.040 Biomarker disease BEFREE Inflammation-driven production and functions of PCa-TDFSs were tested "<i>in vitro</i>" by stimulating established cell lines (CA-HPV-10 and PC3) with IFN-γ or TNF-α. 29896191 2018
CUI: C1739135
Disease: Progression of prostate cancer
Progression of prostate cancer 		0.040 Biomarker disease BEFREE Tumor necrosis factor-alpha (TNF-α) is an important inflammatory cytokine that may play a role in controlling the progression of prostate cancer. 24666463 2014
CUI: C1739135
Disease: Progression of prostate cancer
Progression of prostate cancer 		0.040 GeneticVariation disease BEFREE Ten SNPs in seven genes (CXCL12, IL4, IL6, IL6ST, PTGS2, STAT3, and TNF) were nominally associated (P < 0.05) with risk of PC in Caucasians. 21430300 2011