TNF, tumor necrosis factor, 7124

N. diseases: 2724; N. variants: 31
Disease: Aortic Stiffness ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C3178782
Disease: Aortic Stiffness
Aortic Stiffness 		0.030 Biomarker phenotype BEFREE The aim of the study was to investigate the association between IL-6, TNF, IL-1β, and aortic stiffness in end-stage renal disease patients. 29170076 2018
CUI: C3178782
Disease: Aortic Stiffness
Aortic Stiffness 		0.030 Biomarker phenotype BEFREE The balance of evidence suggests that TNF-a antagonists may have a beneficial effect on aortic stiffness and, therefore, on cardiovascular risk. 28484887 2018
CUI: C3178782
Disease: Aortic Stiffness
Aortic Stiffness 		0.030 Biomarker phenotype BEFREE In conclusion, metabolic syndrome causes tPVAT dysfunction through an interplay between TNFα and NOX2 that leads to tPVAT-mediated aortic stiffness by activation of aortic reactive oxygen species and increased MMP9 activity. 29349831 2018