TNFRSF1A, TNF receptor superfamily member 1A, 7132

N. diseases: 487; N. variants: 48
Disease: Depressive disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.360 Biomarker disease BEFREE Stress-related suppression of TNFα predicted drinking severity only in alcohol-dependent individuals with subclinical depression, and suppressed TNFR1 following stress was only seen in individuals with subclinical depression. 31736187 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.360 AlteredExpression disease BEFREE RESULTS Cerebellar fastigial nucleus stimulation reduced behaviors associated with depression in the rat model, upregulated the expression of miR-29c, and reduced the expression of TNFRSF1A and inflammatory cytokines, and mildly reduced neuronal apoptosis. 31352465 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.360 Biomarker disease BEFREE We investigated interaction between exposure to childhood maltreatment and extensive genetic variation within the inflammation pathway (CRP, IL1b, IL-6, IL11, TNF, TNFR1, and TNFR2) in relation to depression diagnosis. 28867280 2018
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.360 Biomarker disease BEFREE Synaptophysin (SYP), SYP/CD81, and tumor necrosis factor receptor 1 (TNFR1)/CD81 were positively correlated with severities of depression and/or various sub-symptoms. 30059939 2018
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.360 Biomarker disease BEFREE Generalized estimating equations models were used to estimate standardized associations between TNFR1 and 1) baseline functional status and 2) change in function over time, adjusting for demographic factors, vascular risk factors, social variables, cognition, and depression, as well as stroke and MI occurrence during follow-up. 28453789 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.360 Biomarker disease PSYGENET We have assessed TNF(-/-), TNF-R1(-/-) and TNF-R2(-/-) mice against C57BL/6 wild-type (WT) mice from 12 weeks of age in order to evaluate measures of spatial memory and learning in the Barnes maze (BM) and Y-maze, as well as other behaviours such as exploration, social interaction, anxiety and depression-like behaviour in a battery of tests. 24094876 2013
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.360 Biomarker disease PSYGENET Etanercept, a soluble TNF receptor, and TNFR1 deficiency protected against the depression in diaphragm-specific force caused by doxorubicin. 21097524 2011
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.360 Biomarker disease PSYGENET The depression-like behavior was virtually abolished in TNFα p55 receptor-knockout mice, and increased B1 receptor mRNA expression was completely absent in this mouse strain. 21194425 2010
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.360 Biomarker disease BEFREE Circulating levels of interleukin-6 (IL-6), soluble IL-6 receptor (sIL-6R), tumor necrosis factor-alpha-receptor (TNF-RII), and soluble intercellular adhesion molecule (sICAM) did not differ between those with and without depression. 17094069 2007
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.360 Biomarker disease PSYGENET Circulating levels of interleukin-6 (IL-6), soluble IL-6 receptor (sIL-6R), tumor necrosis factor-alpha-receptor (TNF-RII), and soluble intercellular adhesion molecule (sICAM) did not differ between those with and without depression. 17094069 2007
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.360 Biomarker disease PSYGENET We used a panel of behavioral assays to assess TNFR1(-/-) and TNFR2(-/-) mice for anxiety and depression-like behaviors. 16458261 2006