TOP1, DNA topoisomerase I, 7150

N. diseases: 143; N. variants: 10
Disease: melanoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025202
Disease: melanoma
melanoma 		0.020 Biomarker disease BEFREE In this work we investigated the role and involvement of both p53-dependent and -independent mechanisms in selected melanoma cell lines with differing status of p53 using a model DNA topoisomerase I inhibitor camptothecin (CPT). 21809047 2011
CUI: C0025202
Disease: melanoma
melanoma 		0.020 Biomarker disease BEFREE These results show that TOP1 amplification is associated with advanced tumours and poor prognosis in melanoma. 20465595 2010