TOP1, DNA topoisomerase I, 7150

N. diseases: 143; N. variants: 10
Disease: Endotoxemia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0376618
Disease: Endotoxemia
Endotoxemia 		0.010 AlteredExpression phenotype BEFREE In LPS-stimulated RAW264.7 cells and in peritoneal macrophages from endotoxemic mice, NC and TOP1 inhibitors significantly enhanced the activation of Akt, a critical signal transducer for IL-10 production, and inhibition of Akt prevented these compounds from enhancing IL-10 production and ameliorating endotoxemia. 31415918 2019