TOP2A, DNA topoisomerase II alpha, 7153

N. diseases: 200; N. variants: 5
Disease: Small cell carcinoma of lung ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0149925
Disease: Small cell carcinoma of lung
Small cell carcinoma of lung 		0.050 Biomarker disease BEFREE Based on immunohistochemical analysis, TOP2A, MELK and CENPF were involved in SCLC pathogenesis. 28275243 2017
CUI: C0149925
Disease: Small cell carcinoma of lung
Small cell carcinoma of lung 		0.050 AlteredExpression disease BEFREE A panel of doxorubicin-resistant sublines of the human small-cell lung carcinoma cell line GLC4 displays decreasing DNA topoisomerase II alpha (TopoII alpha) mRNA levels with increasing resistance. 8761362 1996
CUI: C0149925
Disease: Small cell carcinoma of lung
Small cell carcinoma of lung 		0.050 AlteredExpression disease BEFREE Differential expression of DNA topoisomerase II alpha and -beta in P-gp and MRP-negative VM26, mAMSA and mitoxantrone-resistant sublines of the human SCLC cell line GLC4. 8980384 1996
CUI: C0149925
Disease: Small cell carcinoma of lung
Small cell carcinoma of lung 		0.050 AlteredExpression disease BEFREE The titration assay was used to quantitate the amount of DNA topoisomerase II alpha mRNA in a human small cell lung carcinoma cell line, GLC4 and its drug-resistant sublines, GLC4/ADR and GLC4/CDDP. 8041119 1994
CUI: C0149925
Disease: Small cell carcinoma of lung
Small cell carcinoma of lung 		0.050 Biomarker disease BEFREE We characterized a rearrangement of the topoisomerase II p170 gene (also known as TOP2) in a relatively chemoresistant SCLC cell line, NCI-H69, and compared topoisomerase II expression and activity in this line with those in the chemosensitive NCI-H187 cell line. 1331483 1992