TOP2A, DNA topoisomerase II alpha, 7153

N. diseases: 200; N. variants: 5
Disease: Metastatic human epidermal growth factor 2 positive carcinoma of breast ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C4721209
Disease: Metastatic human epidermal growth factor 2 positive carcinoma of breast
Metastatic human epidermal growth factor 2 positive carcinoma of breast 		0.010 Biomarker disease BEFREE TOP2A gene amplification was shown to be a favorable prognostic marker in HER2-positive MBC patients treated with trastuzumab, such an effect however, appears to rather be related to treatment with anthracyclines (predictive marker for benefit from anthracyclines). 23092535 2012