|
Malignant neoplasm of urinary bladder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that other sources, in addition to tobacco smoke, may contribute to 4-ABP-DNA adducts formation in bladder tissue and that p53 expression/mutation cannot be considered a prognostic factor in bladder cancer.
|
10650812 |
2000 |
|
Malignant neoplasm of urinary bladder
|
0.600 |
Biomarker
|
disease |
BEFREE |
P53 mutations are frequent in bladder cancer, and adenovirus-mediated p53 gene transfer is growth-inhibitory to bladder cancer cells in vitro.
|
10854151 |
2000 |
|
Malignant neoplasm of urinary bladder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Meanwhile, TPX2 overexpression promoted while overexpression of GLIPR1 or p53 inhibited bladder cancer growth.
|
28799673 |
2018 |
|
Malignant neoplasm of urinary bladder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Polymorphic enzymes of xenobiotic metabolism as modulators of acquired P53 mutations in bladder cancer.
|
9014203 |
1996 |
|
Malignant neoplasm of urinary bladder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The results of this study suggest that BstUI and Msp1 germ line polymorphisms of the tumor suppressor gene p53 marginally modify the risk of bladder cancer.
|
11130248 |
2000 |
|
Malignant neoplasm of urinary bladder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
We investigated associations between two such polymorphisms, and p53 overexpression, and response or survival in bladder cancer patients treated with CRT.
|
19764997 |
2009 |
|
Malignant neoplasm of urinary bladder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
BBN-induced tumors in mice recapitulate the histology of human BC and were characterized with an overexpression of markers typical for basal-like cancer subtype in addition to a high mutational burden with frequent mutations in Trp53, similar to human muscle invasive BC.
|
31779626 |
2019 |
|
Malignant neoplasm of urinary bladder
|
0.600 |
Biomarker
|
disease |
BEFREE |
These results may indicate that alteration of chromosomal regions on 8q and 17p, including c-myc and p53 genes, may be linked to progression of bladder cancer.
|
11848469 |
2002 |
|
Malignant neoplasm of urinary bladder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Gemcitabine/Cisplatin Treatment Induces Concomitant SERTAD1, CDKN2B and GADD45A Modulation and Cellular Changes in Bladder Cancer Cells Regardless of the Site of TP53 Mutation.
|
28577130 |
2018 |
|
Malignant neoplasm of urinary bladder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to elucidate the association between TP53 codon 72 polymorphism and somatic mutations in bladder cancer.
|
31369573 |
2019 |
|
Malignant neoplasm of urinary bladder
|
0.600 |
PosttranslationalModification
|
disease |
BEFREE |
Using a population-based study of bladder cancer (n = 355), we examined epigenetic alterations, specifically gene promoter hypermethylation, of four SFRP genes in addition to immunohistochemical staining of TP53, which has been previously shown to be a predictor of invasive disease.
|
16103055 |
2005 |
|
Malignant neoplasm of urinary bladder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Detection of loss of heterozygosity in the p53 tumor-suppressor gene with PCR in the urine of patients with bladder cancer.
|
10688045 |
2000 |
|
Malignant neoplasm of urinary bladder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
bcl-2/bax expression and p53 gene status in human bladder cancer: relationship to early recurrence with intravesical chemotherapy after resection.
|
9817315 |
1998 |
|
Malignant neoplasm of urinary bladder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Significance of Met overexpression was then compared with p53 nuclear accumulation (TP53) in primary bladder cancer (n = 142 patients).
|
11896103 |
2002 |
|
Malignant neoplasm of urinary bladder
|
0.600 |
Biomarker
|
disease |
BEFREE |
The expression of galectin-7 was analyzed in five bladder cancer cell lines with different p53 status after treatment with CDDP.
|
17283157 |
2007 |
|
Malignant neoplasm of urinary bladder
|
0.600 |
Biomarker
|
disease |
BEFREE |
From the pre-genomic era only p53 emerged as the molecular prognostic factor able to add value to existing clinical and pathological features of bladder cancer, however it was not introduced to the clinic.
|
12605552 |
2003 |
|
Malignant neoplasm of urinary bladder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Consequently, the immunohistochemistry and qPCR results reported in our study suggested the idea that USP28 in coordination with p53 could serve as a marker in BCa progression.
|
31822365 |
2020 |
|
Malignant neoplasm of urinary bladder
|
0.600 |
Biomarker
|
disease |
BEFREE |
We investigated the therapeutic potential and molecular mechanism of adenovirus-mediated wt p53 gene therapy for drug-resistant human bladder cancers.
|
11668510 |
2001 |
|
Malignant neoplasm of urinary bladder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Experimental molecular biomarkers, including p53 expression and gene methylation, and conventional clinicopathological data were studied in a cohort of 117 patients with bladder cancer.
|
16525693 |
2006 |
|
Malignant neoplasm of urinary bladder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
We undertook the present study in order to determine the frequency of MDM2 and TP53 abnormalities in bladder tumors, as well as to examine the clinical relevance of identifying their altered patterns of expression in patients affected with bladder cancer.
|
8064890 |
1994 |
|
Malignant neoplasm of urinary bladder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Experimental molecular biomarkers, including p53 and the mismatch repair proteins, and conventional clinicopathological data were studied in a cohort of 109 patients with bladder cancer.
|
14519642 |
2003 |
|
Malignant neoplasm of urinary bladder
|
0.600 |
Biomarker
|
disease |
BEFREE |
The aim of the present study was to assess the use of an alternative molecular approach for p53 mutation detection and to investigate the usefulness of p53 as a prognostic indicator in bladder cancer.
|
12725329 |
2003 |
|
Malignant neoplasm of urinary bladder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
[Science (Washington DC), 252: 706-709, 1991] showing that p53 gene mutations were frequently found in invasive bladder cancers by sequence analysis on polymerase chain reaction amplified products corresponding to exons 5 to 9.
|
1540947 |
1992 |
|
Malignant neoplasm of urinary bladder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A case-control study was conducted and we observed the genotype distribution of TP53 Arg72Pro SNP, to elucidate the possible role of this SNP as risk factor in urinary bladder cancer (UBC) development and to examine its correlation with the clinicopathologic variables of UBC cases.
|
21156242 |
2010 |
|
Malignant neoplasm of urinary bladder
|
0.600 |
Biomarker
|
disease |
BEFREE |
These findings suggest that RNA interference targeting mutant p53 may be a promising therapeutic strategy for the treatment of bladder cancer.
|
23356234 |
2013 |