Malignant neoplasm of urinary bladder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Consequently, the immunohistochemistry and qPCR results reported in our study suggested the idea that USP28 in coordination with p53 could serve as a marker in BCa progression.
|
31822365 |
2020 |
Malignant neoplasm of urinary bladder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
BBN-induced tumors in mice recapitulate the histology of human BC and were characterized with an overexpression of markers typical for basal-like cancer subtype in addition to a high mutational burden with frequent mutations in Trp53, similar to human muscle invasive BC.
|
31779626 |
2019 |
Malignant neoplasm of urinary bladder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to elucidate the association between TP53 codon 72 polymorphism and somatic mutations in bladder cancer.
|
31369573 |
2019 |
Malignant neoplasm of urinary bladder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The p53 mutation, the expression of p53 and PCDH17 were significantly associated with survival from bladder cancer.
|
31772653 |
2019 |
Malignant neoplasm of urinary bladder
|
0.600 |
Biomarker
|
disease |
BEFREE |
GADD45a Mediated Cell Cycle Inhibition Is Regulated By P53 In Bladder Cancer.
|
31571910 |
2019 |
Malignant neoplasm of urinary bladder
|
0.600 |
Biomarker
|
disease |
BEFREE |
We suggest Survivin, both as a biomarker associated to G3 BCs but negatively related to TP53 mutational status, and as a potential novel therapeutic target.
|
30650148 |
2019 |
Malignant neoplasm of urinary bladder
|
0.600 |
Biomarker
|
disease |
BEFREE |
This study suggests that upregulated HIF1A-AS2 hampers the p53 family proteins dependent apoptotic pathway to promote Cis resistance in bladder cancer.
|
30216500 |
2019 |
Malignant neoplasm of urinary bladder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
GTSE1 overexpression in bladder cancer might participate in the regulation of FoxM1/CCNB1 expression via the induction of the transfer of p53 to cytoplasm.
|
30414902 |
2019 |
Malignant neoplasm of urinary bladder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Intrinsic and/or acquired resistance to cisplatin is a significant obstacle in the treatment of muscle-invasive bladder cancer. p73, a p53 homolog and determinant of chemosensitivity, is rarely mutated in bladder cancer (BC).
|
31318640 |
2019 |
Malignant neoplasm of urinary bladder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
To investigate the prognostic value of tumor-associated trypsin inhibitor (TATI) expression combined with p53 expression in bladder cancer patients who have undergone radical cystectomy.
|
31594208 |
2019 |
Malignant neoplasm of urinary bladder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Tumor cells of luminal, basal, and p53 subtypes of primary and relapsed NMIBC were engrafted to irradiated (3.5 Gy) NOG/SCID female mice along with intraperitoneal transplantation of human lymphocytes (5 × 10<sup>7</sup> cells/mouse); a role of PD-L1 signaling pathway inhibition for bladder cancer growth was assessed in humanized animals that carried PD-L1-expressing main molecular subtypes of bladder carcinoma patient-derived xenografts (PDX) and provided with selective anti-PD-L1 treatment.
|
31159302 |
2019 |
Malignant neoplasm of urinary bladder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Meanwhile, TPX2 overexpression promoted while overexpression of GLIPR1 or p53 inhibited bladder cancer growth.
|
28799673 |
2018 |
Malignant neoplasm of urinary bladder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Gemcitabine/Cisplatin Treatment Induces Concomitant SERTAD1, CDKN2B and GADD45A Modulation and Cellular Changes in Bladder Cancer Cells Regardless of the Site of TP53 Mutation.
|
28577130 |
2018 |
Malignant neoplasm of urinary bladder
|
0.600 |
Biomarker
|
disease |
CTD_human |
Genetic aberrations of the K-ras proto-oncogene in bladder cancer in relation to pesticide exposure.
|
29644616 |
2018 |
Malignant neoplasm of urinary bladder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In the relationship between TP53 codon 72 polymorphisms and BC tumor stage in Asian group, positive results were presented in <i>allele model</i>: OR=1.68, 95% CI=1.04-2.72; <i>dominant model</i>: OR=2.46, 95% CI=1.08-5.61; <i>heterozygous model</i>: OR=2.32, 95% CI=1.04-5.14; <i>homozygote model</i>: OR=2.66, 95% CI=1.04-6.81.
|
30310509 |
2018 |
Malignant neoplasm of urinary bladder
|
0.600 |
Biomarker
|
disease |
BEFREE |
High expression of both cytoplasmic DDX31 and p53 proteins correlated with poor prognosis in patients with MIBC, and blocking the DDX31/NCL interaction resulted in downregulation of EGFR/Akt signaling, eliciting an <i>in vivo</i> antitumor effect against bladder cancer.
|
29440146 |
2018 |
Malignant neoplasm of urinary bladder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Bladder cancer (BC) ranks as the sixth most common cancer in the United States and is the leading cause of death in patients with urinary malignancies. p63 is a member of the p53 family and is believed to function as a tumor suppressor in human BCs.
|
30104251 |
2018 |
Malignant neoplasm of urinary bladder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Therefore, in this study we investigated the cytotoxic and toxicogenetic activity of silibinin in bladder cancer cells with different TP53 statuses.
|
28229968 |
2017 |
Malignant neoplasm of urinary bladder
|
0.600 |
Biomarker
|
disease |
BEFREE |
In spite of extensive literature, little is known about the role of FOXO1 and its relationship with p53 status in bladder cancer.
|
28087474 |
2017 |
Malignant neoplasm of urinary bladder
|
0.600 |
Biomarker
|
disease |
BEFREE |
The mRNA expression levels of the indicated genes, including CCND1, CCNA1, EGFR, AR, CX3CL1, CXCL6, and CXCL1, were significantly increased in urinary bladder from CG and bladder cancer (BC) patients compared with healthy controls, while TP53 was decreased.
|
28285559 |
2017 |
Malignant neoplasm of urinary bladder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Here, we investigated how Rb is integrated to control bladder cancer progression through E2F3 and p53 regulation.
|
27922689 |
2017 |
Malignant neoplasm of urinary bladder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Phthalazino[1,2-b]quinazolinones as p53 Activators: Cell Cycle Arrest, Apoptotic Response and Bak-Bcl-xl Complex Reorganization in Bladder Cancer Cells.
|
28745887 |
2017 |
Malignant neoplasm of urinary bladder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Since p53 protein has become recognized biomarker for both diagnostic and therapeutic purposes in oncological diseases with particular relevance for bladder cancer, it is highly desirable to search for a novel sensing tool for detecting the patient's p53 level at the early stage.
|
29031295 |
2017 |
Malignant neoplasm of urinary bladder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Interestingly, Rb knockout and knockdown result in autophagy and apoptosis inhibition via suppressing p53 and caspase-3 signaling pathways, enhancing bladder cancer development in vitro and in vivo.
|
28259945 |
2017 |
Malignant neoplasm of urinary bladder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Patients from four Northern German institutions with a primary diagnosis of pT1 bladder cancer between 2009 and 2016 and complete data regarding p53 or Ki-67 expression status were included for final analyses.
|
29354488 |
2017 |